Results 141 to 150 of about 29,724,597 (193)
Our results demonstrate massive degeneration of tyrosine hydroxylase‐immunoreactive neurons was observed in the SNpc, striatum, and ventral tegmental area with 6‐OHDA infusions in either the SNpc or striatum. Rats administered 6‐OHDA to the SNpc exhibited cognitive impairments, anxiety‐like behaviors, and impacted the maturation of newborn hippocampal ...
Bianca Andretto de Mattos +4 more
wiley +1 more source
Commentary on: Calpain-2 participates in the process of calpain-1 inactivation. [PDF]
Kumari R, Maiti TK.
europepmc +1 more source
Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling +6 more
wiley +1 more source
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen +1 more
wiley +1 more source
Calpain-1: investigating its role in murine neutrophils [PDF]
Neutrophils are phagocytic white blood cells which act as the first line of defence against entry of foreign microorganisms. Neutrophils are recruited to their target site through the process of spreading, extravasation and phagocytosis involving complex
Ishak, Reezal
core +1 more source
Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation. [PDF]
Park DH +7 more
europepmc +1 more source
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy. [PDF]
Wang J +8 more
europepmc +1 more source
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti +6 more
wiley +1 more source
A Compound Heterozygous Mutation in Calpain 1 Identifies a New Genetic Cause for Spinal Muscular Atrophy Type 4 (SMA4). [PDF]
Perez-Siles G +8 more
europepmc +1 more source
Abstract A common misconception surrounding space exploration is that humanity's pursuit of interplanetary travel, such as missions to Mars, is an escape from Earth. In reality, this endeavour offers an invaluable opportunity to address critical biomedical challenges here at home.
Carina Kern, Tina Woods, Keith Siew
wiley +1 more source

