Results 111 to 120 of about 29,724,597 (193)

Measurement of calpain activity in vitro and in situ using a fluorescent compound and tau as substrates

, 2000
Calpains play important roles in numerous physiological and pathological processes (1,2) by catalyzing the limited proteolysis of a wide variety of protein substrates.
Guttmann, Rodney P. (author), Johnson, Gail V. W. (author)   +1 more
core  

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System

Glia, Volume 74, Issue 11, November 2026.
Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada, Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Binri Sasaki, Momona Yamada, Sakurako Abe, Chikako Hayashi, Akira Yoshimoto, Ryunosuke Ohkawa, Tomal Julian Matt, Florence M Bareyre, Stefan Berghoff, Mikael Simons, Nobuharu Suzuki   +15 more
wiley   +1 more source

β2 Adrenoceptor Signaling Modulates Myoblast Differentiation via miR‐374b‐5p/GSK3β and miR‐326‐3p/Tnfrsf11a Axes

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Myoblast differentiation is a crucial step of skeletal muscle regeneration and is impaired in the absence of the β2 adrenoceptor (ADRβ2). Since miR‐374b and miR‐326 regulate cell differentiation, this study investigated if ADRβ2 regulates myoblast differentiation via miR‐374b‐5p and miR‐326‐3p. Primary myoblasts from ADRβ2 knockout (β2KO) mice
Tatiana E. Koike, Cesar S. Fuziwara, Audrei R. Santos, Fernanda V. B. Delpupo, Tábata L. Nascimento, Andrei Rozanski, Marcelo G. Pereira, Patrícia C. Brum, Edna T. Kimura, Thomas A. Rando, Elen H. Miyabara   +10 more
wiley   +1 more source

Musculoskeletal (Mal)adaptations in Response to a > 30 000‐km Running Challenge

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Ultra‐endurance sports are increasingly popular, yet the long‐term physiological consequences of sustained extreme training loads remain poorly understood. In particular, the effects of prolonged ultra‐endurance exercise on skeletal muscle structure, function and molecular remodelling are largely unknown.
Tomas Venckunas, Thomas Chaillou, Leonardo Cesanelli, Danguole Satkunskiene, Saulius Rutkauskas, Audrius Snieckus, Petras Minderis, Darja Nikitina, Jurgita Skieceviciene, Juozas Kupcinskas, Lorenz Webersberger, Johanna T. Lanner, Mantas Mickevicius, Birutė Gumauskiene, Asta Kuzmickaite, Andrejus Subocius, Sigitas Kamandulis   +16 more
wiley   +1 more source

Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease

MedComm, Volume 7, Issue 10, October 2026.
NETs as integrated effectors in the atherosclerotic cardiovascular disease continuum. Activated neutrophils release NETs that promote endothelial injury, thrombo‐inflammation, and plaque destabilization throughout atherosclerotic disease progression. Created with BioRender.com.
Ji Zhang, Fangjiaqi Wei, Mengdi Qu, Yuwen Shao, Tingye Xu, Darko Stojkov, Hans‐Uwe Simon, Ben Huang, Changhong Miao, Hao Zhang   +9 more
wiley   +1 more source

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

Exploring the Unique and Shared Proteolytic Properties of Calpain-1 and Calpain-2

Calpain-1 (µ-calpain) and calpain-2 (m-calpain) are ubiquitous Ca²⁺-dependent cysteine proteases with overlapping and divergent roles in human cells that remain incompletely defined.
Bulluss, Mitchell
core   +1 more source

The Correlation of Serum Calpain 1 Activity and Concentrations of Interleukin 33 in COVID-19 Acute Respiratory Distress Syndrome. [PDF]

Biomedicines, 2023
Loinjak D, Mihić D, Smolić R, Maričić L, Šahinović I, Smolić M, Sikora R, Loinjak S, Dinjar K, Včev A.   +9 more
europepmc   +1 more source