Results 81 to 90 of about 21,266,386 (226)

Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology [PDF]

Biochemical Journal, 2012
Pharmacological inhibitors of cysteine proteases have provided useful insights into the regulation of calpain activity in erythrocytes. However, the precise biological function of calpain activity in erythrocytes remains poorly understood. Erythrocytes express calpain-1, an isoform regulated by calpastatin, the endogenous inhibitor of calpains.
Wieschhaus A, Khan A, Zaidi A, Rogalin H, Hanada T, Liu F, DE FRANCESCHI, Lucia, Brugnara C, Rivera A, Chishti AH   +9 more
openaire   +3 more sources

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Elevated calpain protein in AngII infused calpain-1 +/+ and calpain-1 −/− aortas.

, 2013
Calpain-1 (A) and calpain-2 (B) proteins were detected by Western blotting in tissue extracts from aortas in calpain-1 +/+ x LDL receptor −/− and calpain-1 −/− x −/− LDL receptor −/− mice infused with either saline or AngII for 7 days.
Venkateswaran Subramanian (447896), Haruhito A. Uchida (447898), Athar H. Chishti (447897), Jessica J. Moorleghen (113038), Anju Balakrishnan (113044), Deborah A. Howatt (113047)   +5 more
core   +1 more source

Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology

Neurobiology of Disease, 2010
Calpain is a ubiquitous calcium-sensitive protease that is essential for normal physiologic neuronal function. However, mitochondrial-mediated-calcium homeostasis alterations may lead to its pathologic activation that jeopardizes neuronal structure and ...
A. Raquel Esteves, Daniela M. Arduíno, Russell H. Swerdlow, Catarina R. Oliveira, Sandra M. Cardoso   +4 more
doaj   +1 more source

The expression of calpain 1 and calpain 2 in spermatogenic cells and spermatozoa of the mouse [PDF]

Reproduction, 2005
Abstract There is some evidence suggesting that Ca2+ is involved in processes that occur during the development and function of spermatozoa. Calcium-dependent proteins, such as calmodulin, are expressed during mammalian spermatogenesis further suggesting that Ca2+ takes part in its regulation.
Irit, Ben-Aharon, Paula R, Brown, Nir, Etkovitz, Edward M, Eddy, Ruth, Shalgi   +4 more
openaire   +2 more sources

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source

A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family

Frontiers in Neurology, 2019
CAPN1 encodes calpain-1, a large subunit of μ-calpain, a calcium-activated cysteine protease widely present in the central nervous system. Mutations in CAPN1 have recently been identified in a complicated form of Hereditary Spastic Paraplegia (HSP) with ...
Stefano Cotti Piccinelli, Maria T. Bassi, Andrea Citterio, Fiore Manganelli, Stefano Tozza, Filippo M. Santorelli, Serena Gallo Cassarino, Filomena Caria, Enrico Baldelli, Anna Galvagni, Lucio Santoro, Alessandro Padovani, Massimiliano Filosto   +12 more
doaj   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

Apoptosis and motor deficits in SPG76 hereditary spastic paraplegia: Calpain 2 inhibition as therapeutic strategy

Pharmacological Research
SPG76 is a complicated form of hereditary spastic paraplegia (HSP) associated with mutations in the CAPN1 gene. The encoded protein, calpain 1, is a calcium-activated cysteine protease that catalyzes the proteolytic cleavage of a variety of cellular ...
Francesca Brivio, Giulia Guarato, Elena Panzeri, Fiore Manganelli, Massimiliano Filosto, Chiara Vantaggiato, Maria Teresa Bassi   +6 more
doaj   +1 more source

Broadening the View: Substance P and Its Metabolism in Pruritus‐Related Diseases

The Journal of Dermatology, EarlyView.
ABSTRACT Chronic pruritus is a debilitating symptom accompanying numerous inflammatory skin diseases and remains a major therapeutic challenge. Neurogenic inflammation plays a central role in its pathogenesis, with the tachykinin substance P acting as a key mediator at the interface of the nervous system, immune cells, and cutaneous tissues.
Thomas Walter, Bjoern B. Burckhardt
wiley   +1 more source