Results 81 to 90 of about 29,724,597 (193)
Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Neuroprotection, EarlyView.Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi +5 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley +1 more source
Allergy, EarlyView.Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang +12 more
wiley +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Elucidating Isoform Specific Roles of Calpain-1 and Calpain-2 in Breast Cancer [PDF]
, 2020 Breast cancer is the most frequently diagnosed women’s cancer in Canada. Average patient survival rates are high, but they are significantly reduced for those patients whose cancer reaches stage IV – metastatic disease.
Shapovalov, Ivan
core
KU80 suppresses endonuclease G activity to preserve genomic integrity
The FEBS Journal, EarlyView.Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan +8 more
wiley +1 more source
Elevated calpain activity in AngII infused calpain-1 +/+ and calpain-1 −/− aortas.
, 2013 Spectrin breakdown products (A) were detected by Western blotting in tissue extracts from aortas in calpain-1 +/+ x LDL receptor −/− and calpain-1 −/− x −/− LDL receptor −/− mice infused with either saline or AngII for 7 days as a measure of calpain ...
Venkateswaran Subramanian (447896) +5 more
core +1 more source
Insect Molecular Biology, EarlyView.Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto +2 more
wiley +1 more source
Calpain is involved in tumor cell migration and invasion in cancer metastasis but not tumor cell-induced platelet aggregation. [PDF]
, 2019 以前より腫瘍細胞が血小板凝集能を惹起し,血行性転移における遠隔臓器の血管内皮への接着に重要な役割を果たすと考えられているが,その分子メカニズムについて不明な点も多い。そこで本研究では,カルシウム依存性細胞内システインプロテアーゼであるcalpain に着目し,癌転移におけるcalpain の役割について検討を行った。B16/BL6メラノーマ細胞株,colon-26直腸がん由来細胞株の遊走能,浸潤能はコントロールと比較しcalpain 阻害剤,ALLN 添加により有意に抑制された ...
二宮, 治彦 +4 more
core
Asian Journal of Andrology, 2018 Calpain activation contributes to hyperglycemia-induced endothelial dysfunction and apoptosis. This study was designed to investigate the role of calpain inhibition in improving diabetic erectile dysfunction (ED) in mice. Thirty-eight-week-old male C57BL/
Hao Li +4 more
doaj +1 more source