Results 61 to 70 of about 21,266,386 (226)

Calpain-1 is required for hydrogen peroxide-induced myotube atrophy

American Journal of Physiology-Cell Physiology, 2009
Recent reports suggest numerous roles for cysteine proteases in the progression of skeletal muscle atrophy due to disuse or disease. Nonetheless, a specific requirement for these proteases in the progression of skeletal muscle atrophy has not been demonstrated.
J M, McClung, A R, Judge, E E, Talbert, S K, Powers   +3 more
openaire   +3 more sources

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Deciphering calpain-1 localization and activation: novel insights into postmortem proteolysis and meat tenderization

Food Production, Processing and Nutrition
The objective of this study was to investigate localization and activation of calpain-1 in chicken muscles postmortem and its contribution to meat tenderization. Results showed that plasma membrane bound and sarcoplasmic calpain-1 content increased early
Muhan Zhang, Suhuan Wei, Jiahui Chen, Weimin Xu, Daoying Wang, Huan Bian, Jiaolong Li, Ruirui Guo, Xue Du, Hongjing He   +9 more
doaj   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes. [PDF]

PLoS ONE, 2010
The immune cells named T lymphocytes circulate around the body fulfilling their role in immunosurveillance by monitoring the tissues for injury or infection.
Lena Svensson, Alison McDowall, Katherine M Giles, Paula Stanley, Stefan Feske, Nancy Hogg   +5 more
doaj   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells. [PDF]

PLoS ONE, 2010
T cell activation and immune synapse formation require the appropriate activation and clustering of the integrin, LFA-1. Previous work has reported that the calpain family of calcium-dependent proteases are important regulators of integrin activation and
Sarah A Wernimont, William T N Simonson, Peter A Greer, Christine M Seroogy, Anna Huttenlocher   +4 more
doaj   +1 more source

Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3‐deficient muscular dystrophy

Animal Models and Experimental Medicine, EarlyView.
We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp, Marlena Rohm, Gabriele Russo, Xavier Helluy, Abdulhadi Kocabas, Martijn Froeling, Felix Kleefeld, Denise Manahan‐Vaughan, Tobias Ruck, Frank Jacobsen, Matthias Vorgerd, Johannes Forsting, Lara Schlaffke   +12 more
wiley   +1 more source

Auditory Stimulation of Slow‐Wave Sleep Promotes Recovery after Brain Injury in an Animal Model

Annals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) significantly reduces the quality of life for millions of survivors worldwide, causing persistent brain tissue damage and cognitive impairments, with no established therapeutic interventions currently available.
Carlos G. Moreira, Adrian Müllner, Meltem Gönel, Pascal Hofmann, Filipe Teixeira, Rosa C. Paolicelli, Inês Dias, Sergio I. Nemirovsky, Christian R. Baumann, Daniela Noain   +9 more
wiley   +1 more source

Characterisation and expression of calpain family members in relation to nutritional status, diet composition and flesh texture in gilthead sea bream (Sparus aurata).

, 2013
Calpains are non-lysosomal calcium-activated neutral proteases involved in a wide range of cellular processes including muscle proteolysis linked to post-mortem flesh softening.
Encarnación Capilla (462852), Fontanillas, Ramon, Navarro Álvarez, Isabel, Salmerón Salvador, Cristina, Salmeron, Cristina, Navarro Isabel, Gutierrez, Joaquim, Isabel Navarro (462849), Daniel García de la serrana (5656525), Ramón Fontanillas (462847), García de la serrana Daniel, Jiménez-Amilburu Vanesa, García de la Serrana Castillo, Daniel, Vanesa Jiménez-Amilburu, Fontanillas Ramón, Jimenez-Amilburu, Vanesa, Ian A. Johnston, Gutiérrez Joaquim, Joaquim Gutiérrez, Capilla, Encarnacion, Ramón Fontanillas, Cristina Salmerón (462843), Gutiérrez Fruitós, Joaquín, Navarro, Isabel, Encarnación Capilla, Salmerón Cristina, Capilla Campos, Encarnación, Ian A. Johnston (39412), Johnston, Ian A., Isabel Navarro, Vanesa Jiménez-Amilburu (462845), Cristina Salmerón, Capilla Encarnación, Johnston Ian A., Jiménez-Amilburu, V., Daniel García de la serrana, Joaquim Gutiérrez (368250), Ian A Johnston, Cristina Salmerón   +38 more
core   +1 more source