Results 41 to 50 of about 59,835 (238)

SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity [PDF]

, 2015
SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood.
Biasiolo, Alessandra, Cannito, Stefania, Cillo, Umberto, Fasolato, Silvano, Gatta, Angelo, Martini, Andrea, Martini, Andrea, Morello, Elisabetta, Parola, Maurizio, Pontisso, Patrizia, Quarta, SANTINA MARIA, Ruvoletto, Mariagrazia, Simonato, Davide, Terrin, Liliana, Turato, Cristian, Villano, Gianmarco, Zanus, Giacomo   +16 more
core   +2 more sources

Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade

BMC Complementary Medicine and Therapies, 2021
Background Podocytes have become a crucial target for interventions in proteinuric kidney diseases. Many studies have reported that overexpression of transient receptor potential cation channel protein 6 (TRPC6) in podocyte injury upregulates ...
Yin Ding, Xuanli Tang, Yuhui Wang, Dongrong Yu, Caifeng Zhu, Jin Yu   +5 more
doaj   +1 more source

Proteolysis of mitochondrial calpain-13 in cerebral ischemia-reperfusion injury

Biochemistry and Biophysics Reports
Calpains are calcium-dependent cysteine proteases activated by intracellular Ca2+. Although calpains mainly exist in the cytosol, calpain-13 is present in the mitochondria in mouse brains; however, the enzymatic properties and physiological functions of ...
Yusaku Chukai, Toru Sudo, Tomokazu Fukuda, Hiroshi Tomita, Eriko Sugano, Taku Ozaki   +5 more
doaj   +1 more source

Physical and chemical processes and the morphofunctional characteristics of human erythrocytes in hyperglycaemia [PDF]

, 2017
Background: This study examines the effect of graduated hyperglycaemia on the state and oxygen-binding ability of hemoglobin, the correlation of phospholipid fractions and their metabolites in the membrane, the activity of proteolytic enzymes and the ...
Bourdon, Jean Christophe, Gromova, Natalia V., Grunyushkin, Igor P., Klenova, Natalia A., Pestryakova, Anastasia A., Prosnikova, Ksenia V., Revin, Victor V., Revina, Elvira S., Sadykhova, Anna V., Solomadin, Ilia N., Tychkov, Alexander Y., Zhelev, Nikolai   +11 more
core   +5 more sources

Effect of oxidation, pH, and ionic strength on calpastatin inhibition of μ- and m-calpain [PDF]

, 2006
The objective of this study was to evaluate the effect of oxidation on μ- and m-calpain activity at varying pH and ionic strength conditions in the presence of calpastatin. In 2 separate experiments, purified porcine skeletal muscle μ- or m-calpain (0.45
Huff-Lonergan, Elisabeth, Huff-Lonergan, Elisabeth, Lonergan, Steven, Lonergan, Steven, Maddock Carlin, K., Rowe, L.   +5 more
core   +2 more sources

Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain [PDF]

, 2001
Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an ...
Anastasi A., Björk I., Bode W., Bradford H. N., Crawford C., Crawford C., Emori Y., Kawasaki H., Ma H., Maki M., Maki M., Mason R. W., Salvesen G., Sorimachi H., Stubbs M. T.   +14 more
core   +1 more source

Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells. [PDF]

PLoS ONE, 2008
Angiotensin II (Ang II) signaling, including matrix metalloproteinase type II (MMP2) activation, has been linked to an age-associated increase in migration capacity of vascular smooth muscle cells (VSMC), and to other proinflammatory features of arterial
Liqun Jiang, Mingyi Wang, Jing Zhang, Robert E Monticone, Richard Telljohann, Gaia Spinetti, Gianfranco Pintus, Edward G Lakatta   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Precise Prediction of Calpain Cleavage Sites and Their Aberrance Caused by Mutations in Cancer

Frontiers in Genetics, 2019
As a widespread post-translational modification of proteins, calpain-mediated cleavage regulates a broad range of cellular processes, including proliferation, differentiation, cytoskeletal reorganization, and apoptosis.
Ze-Xian Liu, Ze-Xian Liu, Kai Yu, Kai Yu, Jingsi Dong, Linhong Zhao, Zekun Liu, Qingfeng Zhang, Shihua Li, Yimeng Du, Han Cheng   +10 more
doaj   +1 more source

Spatio-temporal regulation of calpain activity after experimental myocardial infarction in vivo

Biochemistry and Biophysics Reports, 2021
Background: Calpains are calcium activated cysteine proteases that play a pivotal role in the pathophysiology of cardiac remodeling. Methods: Here, we performed left anterior descending coronary artery ligation in rats as a model for ischemic systolic ...
Kun Zhang, Melissa M. Cremers, Stephan Wiedemann, David M. Poitz, Christian Pfluecke, Frank R. Heinzel, Burkert Pieske, Volker Adams, Antje Schauer, Robert Winzer, Ruth H. Strasser, Axel Linke, Silvio Quick, Felix M. Heidrich   +13 more
doaj   +1 more source