Results 41 to 50 of about 49,188 (286)
Journal of Cellular and Molecular Medicine, 2019 Mitochondrial dynamic disorder is involved in myocardial ischemia/reperfusion (I/R) injury. To explore the effect of mitochondrial calcium uniporter (MCU) on mitochondrial dynamic imbalance under I/R and its related signal pathways, a mouse myocardial I ...
Lichun Guan +8 more
semanticscholar +1 more source
Calpain system protein expression and activity in ovarian cancer [PDF]
, 2019 Purpose: Expression of members of the calpain system are associated with clinical outcome of patients with, amongst others, breast and ovarian cancer, with calpain-2 expression in ovarian cancer being implicated in chemo-resistance and survival.
Nicholls, Holly +7 more
core +1 more source
Calpain-2 participates in the process of calpain-1 inactivation [PDF]
Bioscience Reports, 2020 Abstract Calpain-1 and calpain-2 are highly structurally similar isoforms of calpain. The calpains, a family of intracellular cysteine proteases, cleave their substrates at specific sites, thus modifying their properties such as function or activity.
Fumiko Shinkai-Ouchi +4 more
openaire +2 more sources
Neoplasia: An International Journal for Oncology Research, 2004 Several oncogene and tumor-suppressor gene products are known substrates for the calpain family of cysteine proteases, and calpain is required for transformation by v-src and tumor invasion.
N.O. Carragher, B.D. Fonseca, M.C. Frame
doaj +1 more source
Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. [PDF]
PLoS Genetics, 2010 Calpains constitute a superfamily of Ca2+-dependent cysteine proteases, indispensable for various cellular processes. Among the 15 mammalian calpains, calpain 8/nCL-2 and calpain 9/nCL-4 are predominantly expressed in the gastrointestinal tract and are ...
Shoji Hata +7 more
doaj +1 more source
Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide (R) in isolated perfused rabbit hearts [PDF]
, 2008 The calpain inhibitor A-705253 and the Na(+)/H(+) exchange inhibitor Cariporide (R) were studied in isolated perfused rabbit hearts subjected to 60 min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first ...
Speth, Maria +7 more
core +1 more source
Skeletal Muscle, 2020 Background Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to several stimuli including disease, injury, starvation, and normal aging.
Clayton Whitmore +11 more
doaj +1 more source
Cells, 2022 Mechanical ventilation (MV) is a clinical tool that provides respiratory support to patients unable to maintain adequate alveolar ventilation on their own.
Hayden W. Hyatt +3 more
doaj +1 more source
M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation
Frontiers in Molecular Neuroscience, 2018 Potassium chloride co-transporter 2 (KCC2), a major chloride transporter that maintains GABAA receptor inhibition in mature mammalian neurons, is down-regulated in the hippocampus during epileptogenesis.
Li Wan +6 more
doaj +1 more source
Regulatory role of calpain in neuronal death
Neural Regeneration Research, 2018 Calpains are a group of calcium-dependent proteases that are over activated by increased intracellular calcium levels under pathological conditions. A wide range of substrates that regulate necrotic, apoptotic and autophagic pathways are affected by ...
Si-ying Cheng +4 more
semanticscholar +1 more source