Results 41 to 50 of about 37,520 (214)

Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells. [PDF]

PLoS ONE, 2008
Angiotensin II (Ang II) signaling, including matrix metalloproteinase type II (MMP2) activation, has been linked to an age-associated increase in migration capacity of vascular smooth muscle cells (VSMC), and to other proinflammatory features of arterial
Liqun Jiang, Mingyi Wang, Jing Zhang, Robert E Monticone, Richard Telljohann, Gaia Spinetti, Gianfranco Pintus, Edward G Lakatta   +7 more
doaj   +1 more source

Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease. [PDF]

PLoS ONE, 2015
Here we demonstrate that heat shock protein 90 (HSP90) interacts with calpain-1, but not with calpain-2, and forms a discrete complex in which the protease maintains its catalytic activity, although with a lower affinity for Ca2+.
Monica Averna, Roberta De Tullio, Marco Pedrazzi, Margherita Bavestrello, Matteo Pellegrini, Franca Salamino, Sandro Pontremoli, Edon Melloni   +7 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Precise Prediction of Calpain Cleavage Sites and Their Aberrance Caused by Mutations in Cancer

Frontiers in Genetics, 2019
As a widespread post-translational modification of proteins, calpain-mediated cleavage regulates a broad range of cellular processes, including proliferation, differentiation, cytoskeletal reorganization, and apoptosis.
Ze-Xian Liu, Ze-Xian Liu, Kai Yu, Kai Yu, Jingsi Dong, Linhong Zhao, Zekun Liu, Qingfeng Zhang, Shihua Li, Yimeng Du, Han Cheng   +10 more
doaj   +1 more source

Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis

Arthritis Research & Therapy, 2020
Background Systemic sclerosis (SSc) or scleroderma is an intractable autoimmune disorder that affects multiple organs. The objectives were to investigate clinical correlations of serum calpain activity and high mobility group box 1 (HMGB1) levels with ...
Ji-Na Zheng, Yang Li, Yue-Mei Yan, Yong Yu, Wen-Qi Shao, Qiang Wang   +5 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Characterizing the Catalytic Action of μ-Calpain on Myofibrillar Protein Structure [PDF]

, 2006
Solving the problem of inconsistent meat tenderness is a top priority of the meat industry. This requires a greater understanding of the processes that affect meat tenderness and the adoption of such information by the meat industry. It is essential that
Fraser-Smith, Emma Louise
core  

Calpeptin Reduces Extracellular Vesicle Secretion and Induces Anti-Inflammatory Effects but Upregulates HO-1 and Alters Adiponectin Levels in Human Adipocytes. [PDF]

J Extracell Biol
ABSTRACT Recent studies have shown that adipose tissue (AT) secretes elevated levels of extracellular vesicles (EVs) in obesity, and these EVs play roles in metabolic diseases. The inhibition of calpains has anti‐inflammatory and anti‐fibrotic effects on AT in mice and reduces EV secretion in some cell types in vitro.
Matilainen J, Foster S, Berg V, Tampio J, Turunen T, Mustonen AM, Kyykallio H, Vaittinen M, Männistö V, Pihlajamäki J, Malinen M, Oikari S, Käkelä P, Kaminska D, Luukkonen V, Huttunen KM, Wabitsch M, Nieminen P, Rilla K.   +18 more
europepmc   +2 more sources

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source