Results 61 to 70 of about 49,188 (286)

Endothelial cell calpain as a critical modulator of angiogenesis

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2017
Calpains are a family of calcium-dependent non-lysosomal cysteine proteases. In particular, calpains residing in the endothelial cells play important roles in angiogenesis.
Yixuan Zhang, N. Liu, Yongchen Wang, J. Youn, H. Cai   +4 more
semanticscholar   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Eosinophilic esophagitis–linked calpain 14 is an IL-13–induced protease that mediates esophageal epithelial barrier impairment

JCI Insight, 2016
We recently identified a genome-wide genetic association of eosinophilic esophagitis (EoE) at 2p23 spanning the calpain 14 (CAPN14) gene, yet the causal mechanism has not been elucidated.
B. Davis, E. Stucke, M. Eyad Khorki, V. Litosh, Jeffrey K. Rymer, M. Rochman, J. Travers, Leah C. Kottyan, M. Rothenberg   +8 more
semanticscholar   +1 more source

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source

Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis

Arthritis Research & Therapy, 2020
Background Systemic sclerosis (SSc) or scleroderma is an intractable autoimmune disorder that affects multiple organs. The objectives were to investigate clinical correlations of serum calpain activity and high mobility group box 1 (HMGB1) levels with ...
Ji-Na Zheng, Yang Li, Yue-Mei Yan, Yong Yu, Wen-Qi Shao, Qiang Wang   +5 more
doaj   +1 more source

Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease. [PDF]

PLoS ONE, 2015
Here we demonstrate that heat shock protein 90 (HSP90) interacts with calpain-1, but not with calpain-2, and forms a discrete complex in which the protease maintains its catalytic activity, although with a lower affinity for Ca2+.
Monica Averna, Roberta De Tullio, Marco Pedrazzi, Margherita Bavestrello, Matteo Pellegrini, Franca Salamino, Sandro Pontremoli, Edon Melloni   +7 more
doaj   +1 more source

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

Acta Neuropathologica Communications, 2016
Alterations in calcium homeostasis are widely reported to contribute to synaptic degeneration and neuronal loss in Alzheimer’s disease. Elevated cytosolic calcium concentrations lead to activation of the calcium-sensitive cysteine protease, calpain ...
Ksenia Kurbatskaya, Emma C. Phillips, C. L. Croft, Giacomo Dentoni, M. M. Hughes, Matthew A. Wade, S. Al-Sarraj, C. Troakes, M. O'Neill, B. Perez-Nievas, D. Hanger, Wendy Noble   +11 more
semanticscholar   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Cleavage of Na+ channels by calpain increases persistent Na+ current and promotes spasticity after spinal cord injury

Nature Medicine, 2016
Upregulation of the persistent sodium current (INaP) in motoneurons contributes to the development of spasticity after spinal cord injury (SCI). We investigated the mechanisms that regulate INaP and observed elevated expression of voltage-gated sodium ...
C. Brocard, Vanessa Plantier, P. Boulenguez, S. Liabeuf, Mouloud Bouhadfane, Annelise Viallat-Lieutaud, L. Vinay, F. Brocard   +7 more
semanticscholar   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source