Results 71 to 80 of about 59,835 (238)

The calpain cascade. Mu-calpain activates m-calpain.

The Journal of biological chemistry, 1997
m-Calpain, which usually requires near-millimolar Ca2+ for activation, undergoes autolysis at 25 microM Ca2+ in the presence of mu-calpain. m-Calpain in itself exhibits no sign of autolysis around this Ca2+ concentration. Half-maximal rate of the reaction occurs at 30 microM Ca2+, showing that it is mu-calpain that catalyzes the limited proteolysis of ...
P, Tompa, A, Baki, E, Schád, P, Friedrich   +3 more
openaire   +1 more source

Evaluation of quantitative muscle MRI and an intelligent phenotyping housing system as advanced phenotyping methods in a mouse model of calpain 3‐deficient muscular dystrophy

Animal Models and Experimental Medicine, EarlyView.
We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp, Marlena Rohm, Gabriele Russo, Xavier Helluy, Abdulhadi Kocabas, Martijn Froeling, Felix Kleefeld, Denise Manahan‐Vaughan, Tobias Ruck, Frank Jacobsen, Matthias Vorgerd, Johannes Forsting, Lara Schlaffke   +12 more
wiley   +1 more source

Effects of Yam and Diosgenin on Calpain Systems in Skeletal Muscle of Ovariectomized Rats

Taiwanese Journal of Obstetrics & Gynecology, 2008
Objective: Yam or diosgenin (extracted from the root of wild yam) is traditionally used for hormone replacement in menopausal women. Calpains are crucially related to the degradation of myofibrillar proteins in skeletal muscle.
Kung-Hao Hsu, Chi-Chen Chang, Horng-Der Tsai, Fuu-Jen Tsai, Yao-Yuan Hsieh   +4 more
doaj   +1 more source

The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy [PDF]

, 2016
The calpains are a family of intracellular cysteine proteases that function in a variety of important cellular functions, including cell signalling, motility, apoptosis and survival.
Barsky, Berditchevski, Chen, Ehrlich, Eisenman, Ellis, Gevaert, Martin, Martin, Martin, Martin, Martin, Martin, Martin, Newcomb, Newcomb, Peng, Porn-Ares, Rimm, Rossi, Sawyer, Shaaban, Shaaban, Siman, Simon   +24 more
core   +4 more sources

Calpain and Atherosclerosis

Journal of Atherosclerosis and Thrombosis, 2013
This review highlights the pro-atherogenic roles of Ca(2+)-sensitive intracellular protease calpains. Among more than ten species of calpain isozymes, µ- and m-calpains have been characterized most extensively. These two isozymes are ubiquitously expressed in mammalian tissues, including blood vessels, and tightly regulate functional molecules in the ...
Takuro, Miyazaki, Takayuki, Koya, Yasuyoshi, Kigawa, Tatsunori, Oguchi, Xiao-Feng, Lei, Joo-ri, Kim-Kaneyama, Akira, Miyazaki   +6 more
openaire   +3 more sources

Small vesicles, big potential: A review of innovative exosome delivery and molecular mechanisms in preclinical myocardial infarction models

Animal Models and Experimental Medicine, EarlyView.
This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin, Kovit Pattanapanyasat, Sarawut Kumphune   +2 more
wiley   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Activation and expression of μ-calpain in dorsal root contributes to RTX-induced mechanical allodynia

Molecular Pain, 2017
Background Calpain is a calcium-dependent cysteine protease, and inhibition of calpain by pre-treatment with MDL28170 attenuated the rat mechanical allodynia in a variety of pain models. Postherpetic neuralgia (Shingles) is a neuropathic pain conditioned
Xiao-Cui Yuan, Cai-Hua Wu, Fang Gao, Hong-Ping Li, Hong-Chun Xiang, He Zhu, Xiao-Li Pan, Li-Xue Lin, Yan-Shen Liu, Wei Yu, Bo Tian, Xian-Fang Meng, Man Li   +12 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Deciphering calpain-1 localization and activation: novel insights into postmortem proteolysis and meat tenderization

Food Production, Processing and Nutrition
The objective of this study was to investigate localization and activation of calpain-1 in chicken muscles postmortem and its contribution to meat tenderization. Results showed that plasma membrane bound and sarcoplasmic calpain-1 content increased early
Muhan Zhang, Suhuan Wei, Jiahui Chen, Weimin Xu, Daoying Wang, Huan Bian, Jiaolong Li, Ruirui Guo, Xue Du, Hongjing He   +9 more
doaj   +1 more source