Results 71 to 80 of about 37,520 (214)
Animal Production: Indonesian Journal of Animal Production, 2012 . The purpose of research was to investigate whether there was influence of the addition of concentrates in basal feed on meat tenderness and calpastatin and calpain activities of three muscles of Kejobong does.
M Socheh +3 more
doaj
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
iNew Medicine, EarlyView.This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin +10 more
wiley +1 more source
Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source
Calpain is involved in tumor cell migration and invasion in cancer metastasis but not tumor cell-induced platelet aggregation. [PDF]
, 2019 以前より腫瘍細胞が血小板凝集能を惹起し,血行性転移における遠隔臓器の血管内皮への接着に重要な役割を果たすと考えられているが,その分子メカニズムについて不明な点も多い。そこで本研究では,カルシウム依存性細胞内システインプロテアーゼであるcalpain に着目し,癌転移におけるcalpain の役割について検討を行った。B16/BL6メラノーマ細胞株,colon-26直腸がん由来細胞株の遊走能,浸潤能はコントロールと比較しcalpain 阻害剤,ALLN 添加により有意に抑制された ...
二宮, 治彦 +4 more
core
Neural Regeneration Research, 2016 The neuroprotective property of quercetin is well reported against hypoxia and ischemia in past studies. This property of quercetin lies in its antioxidant property with blood-brain barrier permeability and anti-inflammatory capabilities.
Anand Kumar Pandey +3 more
doaj +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Diet‐induced inflammation is a major cause of muscle degeneration impacting human and animal health. Owing to their anti‐inflammatory and antioxidant properties, polyphenols have attracted considerable interest as feed additives.
Graziella Orso +8 more
wiley +1 more source
Stabilization of calpain large subunits by overexpression of truncated calpain small subunit in L8 myoblasts. [PDF]
, 2010 [[abstract]]The objectives were to investigate the function of the small subunit in the calpain system by expression of the autolytic form of this subunit in L8 myoblasts.
Chung, T. C.;Liang, Y. C.;Yeh, J. Y.;Ou, B. R.
core
Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Neuroprotection, EarlyView.Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi +5 more
wiley +1 more source
Epilepsia OpenEpilepsy is a chronic condition characterized by unpredictable and recurrent spontaneous seizures. In a previous study, we reported that pharmacological inhibition of calpain prevented epileptogenesis in the rat pilocarpine model.
Philip M. Lam +3 more
doaj +1 more source