Results 71 to 80 of about 49,188 (286)
OncoImmunologyTumor-promoting inflammation significantly impacts cancer progression, and targeting inflammatory cytokines has emerged as a promising therapeutic approach in clinical trials.
Zuhairah Binte Hanafi +7 more
doaj +1 more source
Molecular Pain, 2021 Calpain I is a calcium-dependent cysteine protease which has dual effects on tissue inflammation depending on its cellular location. Intracellularly, calpain I has pro-inflammatory properties but becomes anti-inflammatory when exteriorised into the ...
Jason J McDougall +2 more
doaj +1 more source
Research progress on biomarkers of traumatic brain injury
Animal Models and Experimental Medicine, EarlyView.Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen +8 more
wiley +1 more source
Calpain signaling: from biology to therapeutic opportunities in neurodegenerative disorders
Frontiers in Veterinary Science, 2023 Neurodegenerative disorders represent a major and growing healthcare challenge globally. Among the numerous molecular pathways implicated in their pathogenesis, calpain signaling has emerged as a crucial player in neuronal dysfunction and cell death ...
Elsayed Metwally +5 more
doaj +1 more source
, 2013 Calpains are non-lysosomal calcium-activated neutral proteases involved in a wide range of cellular processes including muscle proteolysis linked to post-mortem flesh softening.
Encarnación Capilla (462852) +38 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.We applied quantitative MRI of the lower limb and automated home‐cage phenotyping to a mouse model of calpainopathy to detect early disease changes. At 15 months, calpain 3‐deficient mice showed increased water T2 values correlating with immune cell infiltration in the soleus and gastrocnemius muscles, while assessment of motor activity revealed only ...
Nicolina Südkamp +12 more
wiley +1 more source
Auditory Stimulation of Slow‐Wave Sleep Promotes Recovery after Brain Injury in an Animal Model
Annals of Neurology, EarlyView.Objective Traumatic brain injury (TBI) significantly reduces the quality of life for millions of survivors worldwide, causing persistent brain tissue damage and cognitive impairments, with no established therapeutic interventions currently available.
Carlos G. Moreira +9 more
wiley +1 more source
Inherited Retinal Degeneration: PARP-Dependent Activation of Calpain Requires CNG Channel Activity
Biomolecules, 2022 Inherited retinal degenerations (IRDs) are a group of blinding diseases, typically involving a progressive loss of photoreceptors. The IRD pathology is often based on an accumulation of cGMP in photoreceptors and associated with the excessive activation ...
Jie Yan +7 more
doaj +1 more source
Calpain-mediated degradation of GFAP at 2 h following blast injury.
, 2017 Proteins were isolated from sham control (Sham), low-blast (L-Blast), and high-blast (H-Blast) OHCs at 2 h post-injury and analyzed via western blot for expression of GFAP (A, B) or calpain (C).
Brandy V. Aperi (3815545) +5 more
core +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source