Results 51 to 60 of about 49,188 (286)

Proteolysis of mitochondrial calpain-13 in cerebral ischemia-reperfusion injury

Biochemistry and Biophysics Reports
Calpains are calcium-dependent cysteine proteases activated by intracellular Ca2+. Although calpains mainly exist in the cytosol, calpain-13 is present in the mitochondria in mouse brains; however, the enzymatic properties and physiological functions of ...
Yusaku Chukai, Toru Sudo, Tomokazu Fukuda, Hiroshi Tomita, Eriko Sugano, Taku Ozaki   +5 more
doaj   +1 more source

Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade

BMC Complementary Medicine and Therapies, 2021
Background Podocytes have become a crucial target for interventions in proteinuric kidney diseases. Many studies have reported that overexpression of transient receptor potential cation channel protein 6 (TRPC6) in podocyte injury upregulates ...
Yin Ding, Xuanli Tang, Yuhui Wang, Dongrong Yu, Caifeng Zhu, Jin Yu   +5 more
doaj   +1 more source

Calpain-3 not only proteolyzes calpain-1 and -2 but also is a substrate for calpain-1 and -2

The Journal of Biochemistry, 2023
Abstract Calpain is an intracellular cysteine protease that cleaves its specific substrates in a limited region to modulate cellular function. Calpain-1 (C1) and calpain-2 (C2) are ubiquitously expressed in mammalian cells, but calpain-3 (C3) is a skeletal muscle-specific type.
Koichi Ojima, Shoji Hata, Fumiko Shinkai-Ouchi, Yasuko Ono, Susumu Muroya   +4 more
openaire   +2 more sources

The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury.

Journal of the American Society of Nephrology, 2018
BACKGROUND The hallmark of podocytopathies, such as FSGS, is podocyte injury resulting in proteinuria. Transient receptor potential channel C6 (TRPC6) is a calcium-conducting ion channel expressed at the slit diaphragm.
K. Verheijden, R. Sonneveld, M. Bakker-van Bebber, J. Wetzels, J. van der Vlag, Tom Nijenhuis   +5 more
semanticscholar   +1 more source

Fibronectin induces epithelial-mesenchymal transition in human breast cancer MCF-7 cells via activation of calpain.

Oncology Letters, 2017
Fibronectin (FN) is a primary component of the mammary mesenchymal compartment and undergoes dramatic changes during breast cancer development. Increased FN expression is associated with an invasive and metastatic breast cancer phenotype.
Cheng-lin Li, Dan Yang, Xin Cao, Fan Wang, Duanyang Hong, Jing Wang, Xiang-chun Shen, Yan Chen   +7 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Precise Prediction of Calpain Cleavage Sites and Their Aberrance Caused by Mutations in Cancer

Frontiers in Genetics, 2019
As a widespread post-translational modification of proteins, calpain-mediated cleavage regulates a broad range of cellular processes, including proliferation, differentiation, cytoskeletal reorganization, and apoptosis.
Ze-Xian Liu, Ze-Xian Liu, Kai Yu, Kai Yu, Jingsi Dong, Linhong Zhao, Zekun Liu, Qingfeng Zhang, Shihua Li, Yimeng Du, Han Cheng   +10 more
doaj   +1 more source

Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells. [PDF]

PLoS ONE, 2008
Angiotensin II (Ang II) signaling, including matrix metalloproteinase type II (MMP2) activation, has been linked to an age-associated increase in migration capacity of vascular smooth muscle cells (VSMC), and to other proinflammatory features of arterial
Liqun Jiang, Mingyi Wang, Jing Zhang, Robert E Monticone, Richard Telljohann, Gaia Spinetti, Gianfranco Pintus, Edward G Lakatta   +7 more
doaj   +1 more source

Spatio-temporal regulation of calpain activity after experimental myocardial infarction in vivo

Biochemistry and Biophysics Reports, 2021
Background: Calpains are calcium activated cysteine proteases that play a pivotal role in the pathophysiology of cardiac remodeling. Methods: Here, we performed left anterior descending coronary artery ligation in rats as a model for ischemic systolic ...
Kun Zhang, Melissa M. Cremers, Stephan Wiedemann, David M. Poitz, Christian Pfluecke, Frank R. Heinzel, Burkert Pieske, Volker Adams, Antje Schauer, Robert Winzer, Ruth H. Strasser, Axel Linke, Silvio Quick, Felix M. Heidrich   +13 more
doaj   +1 more source

Calpain and Cardiometabolic Diseases

, 2023
Calpain is defined as a member of the superfamily of cysteine proteases possessing the CysPC motif within the gene. Calpain-1 and -2, which are categorized as conventional isozymes, execute limited proteolysis in a calcium-dependent fashion. Accordingly,
Takuro Miyazaki
core   +1 more source