Results 91 to 100 of about 27,479 (162)

Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
Graphical illustration of the microtubule interactome following spinal cord injury as potential targets for therapy. ABSTRACT Spinal cord injury (SCI) triggers an immediate and sustained disruption of the composition and organization of the neuronal cytoskeleton.
Itzhak Fischer, Peter W. Baas
wiley   +1 more source

The Cavβ4 subunit of Cav1.2 channels antagonizes isoproterenol‐induced hypertrophy in rat cardiac muscle cells by down‐regulating miR‐183‐5p

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract The Cavβ4 subunit of voltage‐gated Cav1.2 channels regulates gene expression in neurons and cardiac cells. It increases the expression of interferon‐β–related genes in H9c2 cardiomyocytes derived from rat ventricular tissue, but the possibility that it also regulates the expression of microRNAs (miRs) remains unexplored.
Elba D. Carrillo, Erick Galicia, María C. García, Jorge A. Sánchez   +3 more
wiley   +1 more source

Deciphering of the reactive oxygen species (ROS) induced calpain activation in cancer progression and its therapeutic potential

Advances in Redox Research
Mitochondrial signalling plays a fundamental role in orchestrating essential intracellular functions, including cellular respiration, proliferation, nucleic acid synthesis, and oxidative stress management.
Krishna Samanta, Ivan Ahel, Pulak Kar
doaj   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Genetic disruption of <i>Capns1</i> impairs metastatic phenotypes in murine mammary carcinoma cells. [PDF]

MicroPubl Biol
Harper D, Shapovalov I, Cockburn S, Aaron A, Gao Y, Greer PA.   +5 more
europepmc   +1 more source

Calpain-4 Knockdown Modulates Cholesterol Metabolism and LXRα Nuclear Localization in Experimental Alcohol-Related Liver Disease. [PDF]

Alcohol Clin Exp Res (Hoboken)
Kitano N, Li J, Taborski S, Vanderpuye CM, Muddasani P, Chaudhary S, Liu JJ, Liu S, Beier JI, Argemi J, Bataller R, Arteel GE.   +11 more
europepmc   +1 more source

Detection of Calpain-Mediated Beclin-1 Cleavage for Drug Discovery in Inflammatory Bowel Diseases. [PDF]

Cells
Hunter KA, Overstreet AC, Koff BB, Dharan H, Overend S, Messer JS.   +5 more
europepmc   +1 more source

Basigin (CD147) and calpain 4 (CapnS1) are partners in the generation of traction force but not in mechanosensing. [PDF]

J Biol Chem
DeTone J, Kozole S, Stewart M, Hao B, Beningo KA.   +4 more
europepmc   +1 more source

Using fibre photometry with a fluorescence resonance energy transfer-based biosensor to test efficacy of calpain inhibitors <i>in vivo</i>. [PDF]

Brain Commun
Robinson KJ, Turner AJ, Ahel HI, Kuriakose A, Potapenko A, Watchon M, Plenderleith SK, Everett NA, McMullan S, Laird AS.   +9 more
europepmc   +1 more source

Correction: Calpain inhibition as a novel therapeutic strategy for aortic dissection with acute lower extremity ischemia. [PDF]

Mol Med
Tan Q, Wang X, Xu W, Song K, Xiong Y, Jiang Z, Li J, Yu Y, Ye W, Shen Z, Teng X.   +10 more
europepmc   +1 more source