Results 91 to 100 of about 37,520 (214)
Elevated calpain protein in AngII infused calpain-1 +/+ and calpain-1 −/− aortas.
, 2013 Calpain-1 (A) and calpain-2 (B) proteins were detected by Western blotting in tissue extracts from aortas in calpain-1 +/+ x LDL receptor −/− and calpain-1 −/− x −/− LDL receptor −/− mice infused with either saline or AngII for 7 days.
Venkateswaran Subramanian (447896) +5 more
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FASEB BioAdvancesAbdominal adiposity is associated with increased risk of abdominal aortic aneurysm (AAA) development. Calpains are non‐lysosomal calcium‐dependent cysteine proteases that are highly expressed in human and experimental AAAs.
Ana Clara Frony +6 more
doaj +1 more source
Genetic Susceptibility to Periodontitis
Journal of Periodontal Research, EarlyView.Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
Honokiol activates calpain activity.
, 2013 Calpain activity was measured with the fluorescent calpain substrate Suc-LLVY-AMC in N87, AGS, MKN45 and SCM-1 cells. (A) Time course responses to honokiol (20 µM) treatment. Data are expressed in terms of fold of control conditions. (B) Honokiol (20 and
Keng Hsin Lan (80696) +2 more
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Psychiatry and Clinical Neurosciences, EarlyView.Substance‐use disorders are increasingly linked to structural and functional brain alterations consistent with neuroaxonal injury. Neurofilament light chain (NfL) is a sensitive blood‐based marker of axonal damage, but evidence in substance‐using populations remains fragmented.
João Antônio Valadão Leal +2 more
wiley +1 more source
Elevated calpain activity in AngII infused calpain-1 +/+ and calpain-1 −/− aortas.
, 2013 Spectrin breakdown products (A) were detected by Western blotting in tissue extracts from aortas in calpain-1 +/+ x LDL receptor −/− and calpain-1 −/− x −/− LDL receptor −/− mice infused with either saline or AngII for 7 days as a measure of calpain ...
Venkateswaran Subramanian (447896) +5 more
core +1 more source
Pharmacological ResearchSPG76 is a complicated form of hereditary spastic paraplegia (HSP) associated with mutations in the CAPN1 gene. The encoded protein, calpain 1, is a calcium-activated cysteine protease that catalyzes the proteolytic cleavage of a variety of cellular ...
Francesca Brivio +6 more
doaj +1 more source
Of mice and men—The emerging oral–gut–brain axis of health and disease
Periodontology 2000, EarlyView.Abstract Objectives Oral health's inextricable links to systemic health are highlighted by the emerging oral–gut–brain axis and other well‐known axes. There is growing evidence of a complex oral–gut–brain axis linking mouth and gut microbiomes with the central nervous system.
Yvonne L. Hernandez‐Kapila +1 more
wiley +1 more source
Elucidating Isoform Specific Roles of Calpain-1 and Calpain-2 in Breast Cancer [PDF]
, 2020 Breast cancer is the most frequently diagnosed women’s cancer in Canada. Average patient survival rates are high, but they are significantly reduced for those patients whose cancer reaches stage IV – metastatic disease.
Shapovalov, Ivan
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