Results 111 to 120 of about 37,520 (214)

TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets [PDF]

, 2016
Several neurological conditions share a characteristic feature: an increase in intracellular calcium levels ([Ca2+]i). It has been demonstrated that calcium influx induces changes ranging from an increase in the expression levels of several genes to ...
Danelon, Víctor, Cragnolini, Andrea Beatriz, Masco, Daniel Hugo   +2 more
core   +1 more source

Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels

mBio
Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, much effort has been dedicated to identifying effective antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Qiru Zeng, Avan Antia, Luis Alberto Casorla-Perez, Maritza Puray-Chavez, Sebla B. Kutluay, Matthew A. Ciorba, Siyuan Ding   +6 more
doaj   +1 more source

Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface

The Journal of Physiology, EarlyView.
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista, Declan Manning, Emily C. Lieu, Stephanie I. Ugochukwu, Collin Matsumoto, Joshua P. Tulman, Miguel Martin‐Aragon Baudel, Nuria Daghbouche‐Rubio, Steven J. McElroy, Sal A. Baker, Manuel F. Navedo, L. Fernando Santana   +11 more
wiley   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Revisiting the calpain hypothesis of learning and memory 40 years later

Frontiers in Molecular Neuroscience
In 1984, Gary Lynch and Michel Baudry published in Science a novel biochemical hypothesis for learning and memory, in which they postulated that the calcium-dependent protease, calpain, played a critical role in regulating synaptic properties and the ...
Michel Baudry, Xiaoning Bi
doaj   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Interaction between calpain and HSP90.

, 2015
(A) Purified calpain-1 or-2 (1.5 µg) was incubated for 1 hour at 25°C with the indicated amounts of purified HSP90. Immunoprecipitation was carried out using 1 µg of anti-HSP90 antibody.
Sandro Pontremoli (309270), Monica Averna (164404), Franca Salamino (309263), Marco Pedrazzi (309260), Margherita Bavestrello (682815), Edon Melloni (164418), Matteo Pellegrini (2078), Roberta De Tullio (365362)   +7 more
core   +1 more source

The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System

Glia, Volume 74, Issue 11, November 2026.
Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada, Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Binri Sasaki, Momona Yamada, Sakurako Abe, Chikako Hayashi, Akira Yoshimoto, Ryunosuke Ohkawa, Tomal Julian Matt, Florence M Bareyre, Stefan Berghoff, Mikael Simons, Nobuharu Suzuki   +15 more
wiley   +1 more source

Neuroprotective Effects of Calpain Inhibition in Parkinson’s Disease: Insights from Cellular and Murine Models

Cells
Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, and key pathways such as neuroinflammation, oxidative stress, and autophagy are believed to significantly contribute to the mechanisms of ...
Vandana Zaman, Amy Gathings, Kelsey P. Drasites, Donald C. Shields, Narendra L. Banik, Azizul Haque   +5 more
doaj   +1 more source

β2 Adrenoceptor Signaling Modulates Myoblast Differentiation via miR‐374b‐5p/GSK3β and miR‐326‐3p/Tnfrsf11a Axes

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Myoblast differentiation is a crucial step of skeletal muscle regeneration and is impaired in the absence of the β2 adrenoceptor (ADRβ2). Since miR‐374b and miR‐326 regulate cell differentiation, this study investigated if ADRβ2 regulates myoblast differentiation via miR‐374b‐5p and miR‐326‐3p. Primary myoblasts from ADRβ2 knockout (β2KO) mice
Tatiana E. Koike, Cesar S. Fuziwara, Audrei R. Santos, Fernanda V. B. Delpupo, Tábata L. Nascimento, Andrei Rozanski, Marcelo G. Pereira, Patrícia C. Brum, Edna T. Kimura, Thomas A. Rando, Elen H. Miyabara   +10 more
wiley   +1 more source