Results 121 to 130 of about 49,188 (286)

Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory

Molecular Brain, 2017
Memory consolidation, reconsolidation, and extinction have been shown to share similar molecular signatures, including new gene expression. Calpain is a Ca2+-dependent protease that exerts its effects through the proteolytic cleavage of target proteins ...
Taikai Nagayoshi, Kiichiro Isoda, Nori Mamiya, Satoshi Kida   +3 more
doaj   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
wiley   +1 more source

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity

Cell Death and Differentiation, 2014
Over recent years, accumulated evidence suggests that autophagy induction is protective in animal models of a number of neurodegenerative diseases. Intense research in the field has elucidated different pathways through which autophagy can be upregulated
Fiona M Menzies, M. García-Arencibia, S. Imarisio, Niamh C. O’Sullivan, T. Ricketts, Brianne A. Kent, Mala Rao, Wun Lam, Zeyn W. Green-Thompson, Ralph A. Nixon, L. Saksida, T. Bussey, C. O’Kane, D. Rubinsztein   +13 more
semanticscholar   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Calpain in Traumatic Brain Injury: From Cinderella to Central Player

Cells
Traumatic Brain Injury (TBI) is a major global health concern and a leading cause of death and disability, especially in young adults. It triggers complex secondary injury cascades, e.g., calcium dysregulation, mitochondrial dysfunction and protease ...
Carla Schallerer, Stephan Neuschmid, Barbara E. Ehrlich, Declan McGuone   +3 more
doaj   +1 more source

Calpain system and its involvement in myocardial ischemia and reperfusion injury.

World Journal of Cardiology, 2014
Calpains are ubiquitous non-lysosomal Ca(2+)-dependent cysteine proteases also present in myocardial cytosol and mitochondria. Numerous experimental studies reveal an essential role of the calpain system in myocardial injury during ischemia, reperfusion ...
C. Neuhof, H. Neuhof
semanticscholar   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets [PDF]

, 2016
Several neurological conditions share a characteristic feature: an increase in intracellular calcium levels ([Ca2+]i). It has been demonstrated that calcium influx induces changes ranging from an increase in the expression levels of several genes to ...
Danelon, Víctor, Cragnolini, Andrea Beatriz, Masco, Daniel Hugo   +2 more
core  

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Interaction between calpain and HSP90.

, 2015
(A) Purified calpain-1 or-2 (1.5 µg) was incubated for 1 hour at 25°C with the indicated amounts of purified HSP90. Immunoprecipitation was carried out using 1 µg of anti-HSP90 antibody.
Sandro Pontremoli (309270), Monica Averna (164404), Franca Salamino (309263), Marco Pedrazzi (309260), Margherita Bavestrello (682815), Edon Melloni (164418), Matteo Pellegrini (2078), Roberta De Tullio (365362)   +7 more
core   +1 more source