Results 101 to 110 of about 59,835 (238)

Ex vivo measurement of calpain activation in human peripheral blood lymphocytes by detection of immunoreactive products of calpastatin degradation.

Folia Histochemica et Cytobiologica, 2008
Limited proteolysis of multiple intracellular proteins by endogenous Ca-dependent cysteine proteases--calpains--is an important regulatory mechanism for cell proliferation, apoptosis etc.
Jacek M Witkowski, Ewa Bryl, Andrzej Hellman, Andrzej Mital, Paulina Lopatniuk, Zaneta Smolenska, Agnieszka Daca, Zofia Puchalska, Anna Zaremba, Anna Mikosik   +9 more
doaj   +1 more source

The genetics of type II diabetes and genetically modified organism technology for insulin [PDF]

, 2016
This paper won a third place writing flag award in the research category. It was written for Jennifer Jones's BIO 325L class, "Lab Experience in Genetics".Jones, JenniferUndergraduate ...
Anderson, Cara
core   +1 more source

Transcriptomic profiling of gill biopsies to define predictive markers for seawater survival in farmed Atlantic salmon

Journal of Fish Biology, EarlyView.
Abstract Wild Atlantic salmon migrate to sea following completion of a developmental process known as parr‐smolt transformation (PST), which establishes a seawater (SW) tolerant phenotype. Effective imitation of this aspect of anadromous life history is a crucial aspect of commercial salmon production, with current industry practice being marred by ...
Lars Grønvold, Mattis J. van Dalum, Anja Striberny, Domniki Manousi, Trine Ytrestøyl, Turid Mørkøre, Solomon Boison, Bjarne Gjerde, Even Jørgensen, Simen R. Sandve, David G. Hazlerigg   +10 more
wiley   +1 more source

The effects of gender and muscle type on the mRNA levels of the calpain proteolytic system and beef tenderness during post-mortem aging [PDF]

, 2016
The objective of this study was to determine the effects of gender and muscle type on the mRNA levels of the calpain system and the tenderization of beef meat.
Boccard, Boehm, Choi, Christopher Heinz Hunke Mberema, Cong, Cong, Cross, Dayton, Destefanis, Doumit, Field, Fritsche, Gandolfi, García Díaz, Geesink, Geesink, Georg Lietz, Gheisari, Goll, Hartwig, Huff-Lonergan, Ilian, Ilian, Ilian, Ilias Kyriazakis, Jiang, Keane, Kemp, Kirchofer, Knight, Kramerova, Labrie, Laure, Lomiwes, Morgan, Morgan, Olivier A.E. Sparagano, Ono, Ono, Parr, Parr, Purchas, Raynaud, Sensky, Sorimachi, Sorimachi, Sullivan, Tang, Taylor, Theil, Vandesompele, Walker, Yang, Zhang   +53 more
core   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory

Molecular Brain, 2017
Memory consolidation, reconsolidation, and extinction have been shown to share similar molecular signatures, including new gene expression. Calpain is a Ca2+-dependent protease that exerts its effects through the proteolytic cleavage of target proteins ...
Taikai Nagayoshi, Kiichiro Isoda, Nori Mamiya, Satoshi Kida   +3 more
doaj   +1 more source

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, EarlyView.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source

Bradyzoite pseudokinase 1 is crucial for efficient oral infectivity of the Toxoplasma gondii tissue cyst.

, 2013
The tissue cyst formed by the bradyzoite stage of Toxoplasma gondii is essential for persistent infection of the host and oral transmission. Bradyzoite pseudokinase 1 (BPK1) is a component of the cyst wall, but nothing has previously been known about its
Adjogble, Boudeau, Bowyer, Boyle, Brown, Brymora, Buchholz, Carey, Craver, Dix, Donald, Dubey, Dunn, Dzierszinski, Fleckenstein, Fox, Friedrich, Fritz, Fritz, Fux, Garrison, Hager, Hanks, Huskinson-Mark, Huynh, Jacobs, John C. Boothroyd, Kawase, Kerry R. Buchholz, Kim, Lavine, Martino, Montoya, Noor, Ong, Parmley, Paul W. Bowyer, Pruitt, Reese, Saeij, Schwarz, Soldati, Tabb, Weiss, Zhang, Zhang   +45 more
core   +1 more source

Serum Hsp70 antigen: Early diagnosis marker in perinatal asphyxia [PDF]

, 2015
BACKGROUND: Perinatal asphyxia is an important cause of mortality and permanent neurological and developmental deficit. Early and accurate diagnosis would help to establish the likely prognosis and may also help in determining the most appropriate ...
Boskabadi, Hassan, Ferns, Gordon A A, Mobarhan, Majid Ghayour, Mohammadi, Shabnam, Omidian, Masoud, Parizadeh, Mostafa, Tavallai, Shima   +6 more
core   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source