Results 101 to 110 of about 49,188 (286)
Elevated calpain protein in AngII infused calpain-1 +/+ and calpain-1 −/− aortas.
, 2013 Calpain-1 (A) and calpain-2 (B) proteins were detected by Western blotting in tissue extracts from aortas in calpain-1 +/+ x LDL receptor −/− and calpain-1 −/− x −/− LDL receptor −/− mice infused with either saline or AngII for 7 days.
Venkateswaran Subramanian (447896) +5 more
core +1 more source
Biochimica et Biophysica Acta, 2015 Both calpain activation and endoplasmic reticulum (ER) stress are implicated in ischemic heart injury. However, the role of calpain in ER stress remains largely elusive.
D. Zheng +4 more
semanticscholar +1 more source
British Journal of Haematology, EarlyView.Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki +8 more
wiley +1 more source
Bacterial calpains and the evolution of the calpain (C2) family of peptidases [PDF]
Biology Direct, 2015 Homologues of calpain, often thought to be an essential, cytoplasmic, calcium-dependent cysteine endopeptidase found exclusively in eukaryotes, have been found in bacterial proteomes. The homologues lack calcium-binding sites, have differing domain architectures, and can be secreted or membrane-associated. Homologues are rare and occur in a minority of
openaire +2 more sources
KU80 suppresses endonuclease G activity to preserve genomic integrity
The FEBS Journal, EarlyView.Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan +8 more
wiley +1 more source
Honokiol activates calpain activity.
, 2013 Calpain activity was measured with the fluorescent calpain substrate Suc-LLVY-AMC in N87, AGS, MKN45 and SCM-1 cells. (A) Time course responses to honokiol (20 µM) treatment. Data are expressed in terms of fold of control conditions. (B) Honokiol (20 and
Keng Hsin Lan (80696) +2 more
core +1 more source
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
The FEBS Journal, EarlyView.Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
Epilepsia OpenEpilepsy is a chronic condition characterized by unpredictable and recurrent spontaneous seizures. In a previous study, we reported that pharmacological inhibition of calpain prevented epileptogenesis in the rat pilocarpine model.
Philip M. Lam +3 more
doaj +1 more source
Elevated calpain activity in AngII infused calpain-1 +/+ and calpain-1 −/− aortas.
, 2013 Spectrin breakdown products (A) were detected by Western blotting in tissue extracts from aortas in calpain-1 +/+ x LDL receptor −/− and calpain-1 −/− x −/− LDL receptor −/− mice infused with either saline or AngII for 7 days as a measure of calpain ...
Venkateswaran Subramanian (447896) +5 more
core +1 more source
The calpain system and diabetes
Pathophysiology, 2014 Diabetes mellitus is recognized as a clinical syndrome that is characterized by hyperglycemia due to deficiency of insulin. The global prevalence of diabetes has been estimated to increase from 4% (1995) to 5.4% by the year 2025. Insulin dependent diabetes mellitus (IDDM/Type-1) in human, generating hyperglycemia due to insulin deficiency as a ...
Muthuraman, Pandurangan +4 more
openaire +2 more sources