Results 131 to 140 of about 49,188 (286)

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Apoptosis and motor deficits in SPG76 hereditary spastic paraplegia: Calpain 2 inhibition as therapeutic strategy

Pharmacological Research
SPG76 is a complicated form of hereditary spastic paraplegia (HSP) associated with mutations in the CAPN1 gene. The encoded protein, calpain 1, is a calcium-activated cysteine protease that catalyzes the proteolytic cleavage of a variety of cellular ...
Francesca Brivio, Giulia Guarato, Elena Panzeri, Fiore Manganelli, Massimiliano Filosto, Chiara Vantaggiato, Maria Teresa Bassi   +6 more
doaj   +1 more source

Measurement of calpain activity in vitro and in situ using a fluorescent compound and tau as substrates

, 2000
Calpains play important roles in numerous physiological and pathological processes (1,2) by catalyzing the limited proteolysis of a wide variety of protein substrates.
Guttmann, Rodney P. (author), Johnson, Gail V. W. (author)   +1 more
core  

Calpain activity in retinal degeneration.

, 2007
Retinal degenerations such as retinitis pigmentosa (RP) or glaucoma are a major cause of blindness in humans. Understanding the mechanisms underlying the various types of retinal degeneration is a pre-requisite for the development of rational therapies ...
Ekström, Per, Johnson, Leif, Paquet-Durand, Francois   +2 more
core   +1 more source

The Molecular Diagnosis of Myopathies: Integrating Genomic, Proteomic, and Pathological Insights Toward Precision Medicine

Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem, Denise de Abreu Pereira, Katia Carneiro   +2 more
wiley   +1 more source

Calpain-Calcineurin-Nuclear Factor Signaling and the Development of Atrial Fibrillation in Patients with Valvular Heart Disease and Diabetes

Journal of Diabetes Research, 2016
Calpain, calcineurin (CaN), and nuclear factor of activated T cell (NFAT) play a key role in the development of atrial fibrillation. Patients with valvular heart disease (VHD) are prone to develop atrial fibrillation (AF).
Yong Zhao, Guo-ming Cui, Nan-nan Zhou, Cong Li, Qing Zhang, Hui Sun, Bo Han, Cheng-wei Zou, Li-juan Wang, Xiao-dong Li, Jian-chun Wang   +10 more
doaj   +1 more source

Calpain is involved in tumor cell migration and invasion in cancer metastasis but not tumor cell-induced platelet aggregation.

, 2019
以前より腫瘍細胞が血小板凝集能を惹起し,血行性転移における遠隔臓器の血管内皮への接着に重要な役割を果たすと考えられているが,その分子メカニズムについて不明な点も多い。そこで本研究では,カルシウム依存性細胞内システインプロテアーゼであるcalpain に着目し,癌転移におけるcalpain の役割について検討を行った。B16/BL6メラノーマ細胞株,colon-26直腸がん由来細胞株の遊走能,浸潤能はコントロールと比較しcalpain 阻害剤,ALLN 添加により有意に抑制された ...
二宮, 治彦, ノボルオ, イッペイ, 田代, ゆう子, 上妻, 行則, 登尾, 一平   +4 more
core  

Calpain-1 and Calpain-2 Promote Breast Cancer Metastasis

In breast cancer, progression from localized stage I to distant metastatic stage IV disease is associated with a reduction of 5-year survival from nearly 100% to 23.2%.
Shapovalov, Ivan, James A. MacLeod, Harper, Danielle, Peter A. Greer, Gao, Yan, Greer, Peter A., Samantha Cockburn, Cockburn, Samantha, Jung Yeon Min, Iryna Predko, Yan Gao, Min, Jung Yeon, Predko, Iryna, Danielle Harper, MacLeod, James A., Ivan Shapovalov   +15 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Stabilization of calpain large subunits by overexpression of truncated calpain small subunit in L8 myoblasts.

, 2010
[[abstract]]The objectives were to investigate the function of the small subunit in the calpain system by expression of the autolytic form of this subunit in L8 myoblasts.
Chung, T. C.;Liang, Y. C.;Yeh, J. Y.;Ou, B. R.
core