Formation of the calpain-1/calpastatin complex promotes activation of calpain-1 under oxidizing conditions [PDF]
Calpains are cysteine proteinases responsible for many biological roles in muscle, including protein degradation, muscle growth, and myoblast fusion. Calpains are inhibited by calpastatin, an endogenous inhibitor. Other factors, such as variations in pH,
Lonergan, Steven +3 more
core
PGC-1α and PPARs cooperatively mediate photoreceptor neuroprotection in rd1 mouse inherited retinal degeneration. [PDF]
Cell Death DisWang L +7 more
europepmc +1 more source
Experimental Physiology, Volume 111, Issue 9, Page 4179-4194, 1 September 2026.Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti +6 more
wiley +1 more source
Purification and characterization of recombinant calpain-5 [PDF]
Recombinant human calpain-5 was expressed in insect cells using a baculovirus system. The expressed calpain-5 was purified by both traditional chromatography and by affinity-column chromatography. Both methods yielded active protease. Calpain-5 displayed
Wang, Mei-Chuan
core +1 more source
Calpains as Potential Regulators of Microtubule-Associated Cytokinesis: A Cross-Eukaryotic Unifying Hypothesis. [PDF]
Life (Basel)Fletcher JC +2 more
europepmc +1 more source
Experimental Physiology, Volume 111, Issue 9, Page 4064-4072, 1 September 2026.Abstract A common misconception surrounding space exploration is that humanity's pursuit of interplanetary travel, such as missions to Mars, is an escape from Earth. In reality, this endeavour offers an invaluable opportunity to address critical biomedical challenges here at home.
Carina Kern, Tina Woods, Keith Siew
wiley +1 more source
Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker
The Journal of Physiology, Volume 604, Issue 17, Page 7246-7263, 1 September 2026.Abstract figure legend The peptide toxin charybdotoxin (ChTx) from the scorpion Leiurus quinquestriatus was tested on single‐channel currents of the ryanodine receptor incorporated into planar lipid bilayers. The structure–function relationship of ChTx was investigated using toxin variants generated by isosteric substitutions of the basic amino acids ...
Zsuzsanna Édua Magyar +10 more
wiley +1 more source
α1-Antitrypsin attenuates microglial NLR family pyrin domain containing 3 inflammasome activation via cannabinoid receptor 2 signaling to ameliorate α-synucleinopathy-related behavioral deficits. [PDF]
Mol BiomedFeng L +8 more
europepmc +1 more source
Long‐term imoxin treatment does not attenuate disease severity in dystrophic diaphragm of male mice
Physiological Reports, Volume 14, Issue 18, September 2026.Abstract Duchenne muscular dystrophy (DMD) is characterized by chronic skeletal muscle injury and degeneration. We discovered activation of protein kinase R (PKR; EIF2AK2), a regulator of the integrated stress response, in dystrophic muscle; however, its role in DMD remains unknown.
Ji Heun Lee +4 more
wiley +1 more source
Withdrawal: Human calpain-3 and its structural plasticity: Dissociation of a homohexamer into dimers on binding titin. [PDF]
J Biol ChemYe Q +4 more
europepmc +1 more source