Results 191 to 200 of about 84,218 (260)

Systematic discovery of CRISPR-boosted CAR T cell immunotherapies. [PDF]

Nature
Datlinger P, Pankevich EV, Arnold CD, Pranckevicius N, Lin J, Romanovskaia D, Schaefer M, Piras F, Orts AC, Nemc A, Biesaga PN, Chan M, Neuwirth T, Artemov AV, Li W, Ladstätter S, Krausgruber T, Bock C.   +17 more
europepmc   +1 more source

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai, Shriarjun Shastry, Morgan R. Hurst, Arianna Minzoni, Eduardo Barbieri, Luke Remmler, Eugene N. Muratov, Michael A. Daniele, Stefano Menegatti, Alexander Tropsha   +9 more
wiley   +1 more source

Quantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAs. [PDF]

Mol Cell
Lewis CJT, Xie LH, Bhandarkar SM, Jin D, Abdallah K, Draycott AS, Chen Y, Thoreen CC, Gilbert WV.   +8 more
europepmc   +1 more source

An automated microfluidic biosensor with bispecific rabbit monoclonal antibody and nanozyme‐bioenzyme composite for dual antibiotic detection

BMEMat, EarlyView.
This study introduces an automated microfluidic biosensor for simultaneous detection of florfenicol and thiamphenicol in environmental water. By integrating a phage‐screened bispecific rabbit monoclonal antibody with a nanozyme‐bioenzyme composite, the system achieves sensitive dual‐antibiotic detection. Coupled with smartphone‐based sensing, it offers
Fuyuan Zhang, Yang Liu, Juntao Wang, Haichao Zhang, Wenlong Yu, Yaxin Sang, Yun Liu, Guangze Yang, Fang Gao, Shuo Wang, Shilun Feng, Xianghong Wang   +11 more
wiley   +1 more source

Green-synthesized silver nanoparticles for improved heat stress resilience and germination in potato seeds. [PDF]

RSC Adv
Lina JM, Mostafa MS, Yeasmin S, Tasnim N, Dipto AR, Das H, Amin MN, Khan NMU, Habib A, Rahman M.   +9 more
europepmc   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

An automated end-to-end system for schistosome viability assessment to accelerate anti-schistosomal drug discovery. [PDF]

PLoS Negl Trop Dis
Liu P, Cheng W, Wang Y, Liu B, Zhu X, Chen G, Wang J, Wu B.   +7 more
europepmc   +1 more source

The Technology Valley of Death of Circular Economy Solutions: A System Dynamics Simulation of Business Strategies for the Second‐Use Battery Industry

Business Strategy and the Environment, EarlyView.
ABSTRACT Retired electric vehicle (EV) batteries can be repurposed to stationary storage batteries. While this circularity solution has attracted attention from entrepreneurs, falling battery prices, along with the longer lifetime of new batteries, high consumer expectations and limited governmental support challenge the approach.
Juliane Seika, Merla Kubli
wiley   +1 more source

Highly selective and AI-predictable Se-N exchange chemistry between benzoselenazolones and boronic acids for programmable, parallel, and DNA-encoded library synthesis. [PDF]

Chem Sci
Zhou W, Wang Y, Zhang S, Zhang C, Pang J, Hou S, Li J, Yao Y, Su A, Ma P, Xu H, Hou W.   +11 more
europepmc   +1 more source

Electrophilic Functionalization of Donor‐Stabilized Phosphanylboranes: A New Pathway toward Heavy 13/14/15 Parent Hydride‐Containing Compounds

ChemistryEurope, EarlyView.
A new way of obtaining mixed 13/14/15 hydride containing compounds stabilized only by a Lewis base is presented. The functionalization of IDipp·BH2PH2 (IDipp = 1,3‐Bis‐(2,6‐diisopropylphenyl)‐imidazolin‐2‐ylidene) by main group electrophiles leads to the formation of the compounds [IDipp·BH2PH2E]+ [E = H, CH3 SiEt3, Ge(SiMe3)3, SnMe3) which represent a
Robert Szlosek, Michael Seidl, Christoph Riesinger, Lisa Zimmermann, Amelie Sophie Niefanger, Christian Marquardt, Alexey Y. Timoshkin, Manfred Scheer   +7 more
wiley   +1 more source