Results 221 to 230 of about 95,314 (260)

DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.

Journal of Medicinal Chemistry
Respiratory syncytial virus (RSV) remains a public health burden due to unmet therapeutic needs. We recently reported the discovery of a non-nucleoside inhibitor of the RSV polymerase and characterized its binding to a novel pocket within the capping ...
Sean M. Carney, Sandrine Grosse, Yanting Yin, Minh T Tran, Jay H Kalin, Edgar Jacoby, Amy Fung, Nicholas Simmons, Xiaoming Xie, Anusarka Bhaumik, Rodrigo J Carbajo, Madison Piassek, Robyn Miller, Lili Hu, Cynthia Lemmens, Ferdinand H. Lutter, Serge Pieters, Geert Rombouts, Irene Vetrano, Daniel Oehlrich, Sonia Tomaso, Kate Lozada, Miguel Osorio Garcia, Brandon Anson, Suzanne de Bruyn, Constance Smith-Monroy, Jean-Marc Neefs, Nádia Conceição-Neto, Bart Kesteleyn, Roberto Fino, B. Stoops, Herman van Vlijmen, Aaron Patrick, Xiaodi Yu, Victoria Wong, Daniel J Krosky, Pravien Abeywickrema, Rodrigo F. Ortiz-Meoz, Stephen W. Mason, Zhinan Jin, Sujata Sharma, T. Jonckers   +41 more
semanticscholar   +1 more source

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication

Science, 2023
Orthomyxo- and bunyaviruses steal the 5′ cap portion of host RNAs to prime their own transcription in a process called “cap snatching.” We report that RNA modification of the cap portion by host 2′-O-ribose methyltransferase 1 (MTr1) is essential for the
Y. Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, T. Claff, Jianyu Hou, V. Namasivayam, Anja vom Hemdt, Satoko Sugimoto, J. Ng, M. H. Christensen, Y. Tesfamariam, Steven Wolter, S. Juranek, T. Zillinger, Stefan Bauer, T. Hirokawa, F. Schmidt, G. Kochs, M. Shimojima, Yi-shuian Huang, A. Pichlmair, B. Kümmerer, Y. Sakoda, M. Schlee, Linda Brunotte, C. Müller, Manabu Igarashi, H. Kato   +29 more
semanticscholar   +1 more source

Going beyond RGD: screening of a cell-adhesion peptide library in 3D cell culture

Biomedical Materials, 2020
In tissue engineering, cell-adhesion peptides (CAPs) such as the ubiquitous arginine–glycine–aspartic acid (RGD) sequence have allowed the functionalization of synthetic materials to mimic macromolecules of the extracellular matrix (ECM).
Mariah Sarwat, Denver C. Surrao, Nick Huettner, J. S. St John, Tim R. Dargaville, Aurélien Forget   +5 more
semanticscholar   +1 more source

Rapid Screening and Effective Rabbit-Derived Fab Antibodies Production Based on Yeast Surface Display.

Combinatorial chemistry & high throughput screening
BACKGROUND Antibodies have broad applications in various fields, such as biology and medicine. The screening and preparation of highly specific and sensitive antibodies are essential research areas. Several techniques for the preparation of mouse-derived
Weili Shen, Tingting Gong, Changli Shao
semanticscholar   +1 more source

LEVERAGING PUBLIC LIBRARIES FOR COMMUNITY HEALTH A CASE STUDY OF CANCER AWARENESS INITIATIVES BY THE ANAMBRA STATE LIBRARY BOARD (2016–2025)

Library and Information Science Digest
This study explores the pivotal role of the Anambra State Library Board in promoting cancer awareness through its health information services from 2016 to 2025, aligned with Sustainable Development Goal 3 (Good Health and Wellbeing).
Nkechi Sabina Udeze, Okeoma Ezechukwu, Ngozi P. Osuchukwu   +2 more
semanticscholar   +1 more source

Discovery of novel inhibitors of histone deacetylase 6: Structure-based virtual screening, molecular dynamics simulation, enzyme inhibition and cell viability assays.

Life Science
Histone deacetylase 6 (HDAC6) contributes to cancer metastasis in several cancers, including triple-negative breast cancer (TNBC)-the most lethal form that lacks effective therapy.
A. Uba, Mariya Hryb, Mursalin Singh, Candice Bui-Linh, Annie Tran, Jiancarlo Atienza, S. Misbah, Xiaoyang Mou, Chun Wu   +8 more
semanticscholar   +1 more source

Effects of health education on screening rate of first-degree relatives of cancer patients: A systematic review and meta-analysis

Journal of Medical Screening
Objective To synthesize the effects of educational intervention on the screening rate of first-degree relatives of cancer patients. Methods A total of eight Chinese and English databases were searched (PubMed, Embase, Cochrane Library, CINAHL, Web of ...
Jiaxun Kang, Shanshan Wang, Jingna Yi, Qiushi Zhang   +3 more
semanticscholar   +1 more source

High-throughput fabrication and screening improves gold nanoparticle chemiresistor sensor performance.

ACS Combinatorial Science, 2015
Lee J. Hubble, J. Cooper, Andrea Sosa-Pintos, H. Kiiveri, Edith Chow, M. Webster, L. Wieczorek, B. Raguse   +7 more
semanticscholar   +1 more source

Library synthesis using solution phase capping of solid phase derived intermediates

, 2000
S. Teague, I. Walters
semanticscholar   +1 more source

Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments.

Gene, 2000
X. Chu, D. S. Thompson, L. J. Yee, L. Sung   +3 more
semanticscholar   +1 more source