Results 221 to 230 of about 84,218 (260)

Hunting the subset-specific genes of neuroblastoma: Expression profiling and differential screening of the full-length-enriched oligo-capping cDNA libraries

Medical and Pediatric Oncology, 2000
Neuroblastoma (NBL) has a distinct nature in different prognostic subgroups.To understand the molecular mechanism of NBL's genesis and biology as well as that of the neural crest development, we constructed full-length-enriched cDNA libraries by an oligo-capping method from two different subsets of primary NBL, one with favorable biology and the other ...
M, Ohira, T, Shishikura, T, Kawamoto, H, Inuzuka, A, Morohashi, H, Takayasu, H, Kageyama, N, Takada, M, Takahashi, S, Sakiyama, Y, Suzuki, S, Sugano, H, Kuma, I, Nozawa, A, Nakagawara   +14 more
  +6 more sources

Association between favorable neuroblastoma and high expression of the novel metalloproteinase gene,nbla3145/XCE, cloned by differential screening of the full-length-enriched oligo-capping neuroblastoma cDNA libraries

Medical and Pediatric Oncology, 2000
The biology of neuroblastoma (NBL) is at least partly regulated by neurotrophic factors and their receptors.To identify novel NBL-related genes that affect growth, differentiation, and programmed cell death of the tumor, we constructed full-length-enriched cDNA libraries by oligo-capping method.Semi-quantitative and quantitative real-time RT-PCR showed
T, Kawamoto, T, Shishikura, M, Ohira, H, Takayasu, A, Morohashi, N, Takada, M, Takahashi, Y, Suzuki, S, Sugano, T, Hori, A, Nakagawara   +10 more
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Applications of chemogenomic library screening in drug discovery

Nature Reviews Drug Discovery, 2017
Lyn H Jones
exaly   +2 more sources

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication

Science, 2023
Orthomyxo- and bunyaviruses steal the 5′ cap portion of host RNAs to prime their own transcription in a process called “cap snatching.” We report that RNA modification of the cap portion by host 2′-O-ribose methyltransferase 1 (MTr1) is essential for the
Y. Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, T. Claff, Jianyu Hou, V. Namasivayam, Anja vom Hemdt, Satoko Sugimoto, Jin Ying Ng, M. H. Christensen, Y. Tesfamariam, Steven Wolter, S. Juranek, T. Zillinger, Stefan Bauer, T. Hirokawa, F. Schmidt, G. Kochs, M. Shimojima, Yi-shuian Huang, A. Pichlmair, B. Kümmerer, Y. Sakoda, M. Schlee, Linda Brunotte, C. Müller, Manabu Igarashi, H. Kato   +29 more
semanticscholar   +1 more source

DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.

Journal of Medicinal Chemistry
Respiratory syncytial virus (RSV) remains a public health burden due to unmet therapeutic needs. We recently reported the discovery of a non-nucleoside inhibitor of the RSV polymerase and characterized its binding to a novel pocket within the capping ...
Sean M Carney, Sandrine Grosse, Yanting Yin, Minh T Tran, Jay H Kalin, Edgar Jacoby, Amy Fung, Nicholas Simmons, Xiaoming Xie, Anusarka Bhaumik, Rodrigo J Carbajo, Madison Piassek, Robyn Miller, Lili Hu, Cynthia Lemmens, Ferdinand H. Lutter, Serge Pieters, Geert Rombouts, Irene Vetrano, Daniel Oehlrich, Sonia Tomaso, Kate Lozada, Miguel Osorio Garcia, Brandon Anson, Suzanne de Bruyn, Constance Smith-Monroy, Jean-Marc Neefs, Nádia Conceição-Neto, Bart Kesteleyn, Roberto Fino, B. Stoops, Herman van Vlijmen, Aaron Patrick, Xiaodi Yu, Victoria Wong, Daniel J Krosky, Pravien Abeywickrema, Rodrigo F. Ortiz-Meoz, Stephen W. Mason, Zhinan Jin, Sujata Sharma, T. Jonckers   +41 more
semanticscholar   +1 more source

Ultrashort Peptides as Stabilizing Agents for Colloidal Nanogold.

ACS Applied Materials and Interfaces
Ultrashort peptides hold immense potential as structural tools for enhancing the colloidal stability of nanomaterials, such as nanogold. However, such applications have been largely unexplored in part due to the inherent complexity in designing ...
Juan David Figueroa, Sergio D. García Schejtman, Ryan Tu, Marcelo Muñoz, Francisca Salas-Sepulveda, Horacio Poblete, M.-A. Langlois, E. Suuronen, Emilio I. Alarcon   +8 more
semanticscholar   +1 more source

Going beyond RGD: screening of a cell-adhesion peptide library in 3D cell culture

Biomedical Materials, 2020
In tissue engineering, cell-adhesion peptides (CAPs) such as the ubiquitous arginine–glycine–aspartic acid (RGD) sequence have allowed the functionalization of synthetic materials to mimic macromolecules of the extracellular matrix (ECM).
Mariah Sarwat, Denver C. Surrao, Nick Huettner, J. S. St John, Tim R. Dargaville, Aurélien Forget   +5 more
semanticscholar   +1 more source

Rapid Screening and Effective Rabbit-Derived Fab Antibodies Production Based on Yeast Surface Display.

Combinatorial chemistry & high throughput screening
BACKGROUND Antibodies have broad applications in various fields, such as biology and medicine. The screening and preparation of highly specific and sensitive antibodies are essential research areas. Several techniques for the preparation of mouse-derived
Weili Shen, Tingting Gong, Changli Shao
semanticscholar   +1 more source

Effects of health education on screening rate of first-degree relatives of cancer patients: A systematic review and meta-analysis

Journal of Medical Screening
Objective To synthesize the effects of educational intervention on the screening rate of first-degree relatives of cancer patients. Methods A total of eight Chinese and English databases were searched (PubMed, Embase, Cochrane Library, CINAHL, Web of ...
Jiaxun Kang, Shanshan Wang, Jingna Yi, Qiushi Zhang   +3 more
semanticscholar   +1 more source