Results 1 to 10 of about 29,693,476 (122)
Revue Marocaine des Sciences Agronomiques et VétérinairesL’élevage des caprins nains en Afrique subsaharienne est très peu modernisé. Plusieurs facteurs zootechniques de production ne sont pas maîtrisés par les éleveurs.
Alex Stéphane Affian EMANFO +2 more
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Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.A study on small ruminant farmers' knowledge identified three profiles (G1, G2, G3): the majority, young men, favor the Djallonké breed due to its affordability. While groups G1 and G2 showed a low level of knowledge due to extensive farming practices, group G3 stood out.
Ganiou Guedegbe +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Advanced Biology, Volume 9, Issue 12, December 2025.Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
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中链甘油三酯中甘油二酯的分离与结构鉴定Isolation and identification of diglycerides from medium-chain triglycerides
Zhongguo youzhi旨在阐明中链甘油三酯产品中的主要副产物甘油二酯类杂质的化学成分，以中链甘油三酯为原料，通过硅胶柱层析和半制备高效液相色谱法分离其中的甘油二酯，并通过核磁谱、质谱、红外光谱、紫外光谱和气相色谱对甘油二酯的结构进行鉴定。结果表明：从中链甘油三酯中分离出6种甘油二酯（DG-1~DG-6），结构依次被鉴定为1，3-二辛酸甘油二酯、1，2-二辛酸甘油二酯、1，3-辛酸癸酸甘油二酯、1，2-辛酸癸酸甘油二酯、1,3-二癸酸甘油二酯、1,2-二癸酸甘油二酯 ...
王国财，唐顺之，袁诚，李继荣，牟肖男，许文东王国财，唐顺之，袁诚，李继荣，牟肖男，许文东
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Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease
FASEB BioAdvances, Volume 7, Issue 11, November 2025.Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur +4 more
wiley +1 more source
RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration
Journal of Neurochemistry, Volume 169, Issue 11, November 2025.Under physiological conditions, neuronal RNA granules (e.g., transport granules, activity‐dependent granules, processing bodies, and stress granules) cooperate to regulate mRNA transport, storage, and localized translation, thereby sustaining synaptic and neuronal functions.
Rita Nóbrega‐Martins +5 more
wiley +1 more source
Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules
Advanced Science, Volume 12, Issue 34, September 11, 2025.These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu +17 more
wiley +1 more source
Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid
Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile +4 more
wiley +1 more source
Toward Design Principles for Biomolecular Condensates for Metabolic Pathways
Advanced Biology, Volume 9, Issue 5, May 2025.Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André +3 more
wiley +1 more source