Results 1 to 10 of about 107,706,999 (142)

Caprin-1 Binding to the Critical Stress Granule Protein G3BP1 Is Influenced by pH [PDF]

Open Biology, 2023
G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formation ...
Leo Hanke, Xaquin Castro Dopico, Adnane Achour   +2 more
exaly   +7 more sources

Radiopharmaceutical Application of TRK-950, an Anti-CAPRIN-1 Therapeutic Antibody [PDF]

Journal of Cancer Research and Clinical Oncology
Purpose Tumor imaging or therapy using cancer specific carriers combined with a radioisotope has huge potential. In radiopharmaceutical development, it is important to ensure target specificity and minimal binding to normal tissues for both tumor ...
Jean-Yves Blay, David Kryza, Benjamin Gibert   +2 more
exaly   +6 more sources

MicroRNA-181a Functions as an Oncogene in Gastric Cancer by Targeting Caprin-1 [PDF]

Frontiers in Pharmacology, 2019
MicroRNA-181a (miRNA-181a) is a multifaceted miRNA implicated in various cellular processes, particularly in cell fate determination and cellular invasion.
Dan Sun, Yanchun Chen, Fenghua Zhou
exaly   +9 more sources

Caprin-1 Influences Autophagy-Induced Tumor Growth and Immune Modulation in Pancreatic Cancer [PDF]

Journal of Translational Medicine, 2023
Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by rapid progression and poor prognosis. Understanding the genetic mechanisms that affect cancer properties and reprogram tumor immune microenvironment will develop new strategies to ...
Bei Sun, Le Li, Chen Hongze
exaly   +5 more sources

Can CAPRIN-1 Be Responsible for the Recurrence Potential of Odontogenic Keratocysts? [PDF]

eJournal of Oral Maxillofacial Research
Objectives: The purpose of this retrospective study is to compare dentigerous cysts and odontogenic keratocysts for cytoplasmic activation/proliferation - associated protein-1 antibodies via immunohistochemical staining to obtain a new perspective about ...
Nelli Yildirimyan, Mehmet Ali Altay, İrem Hicran Özbudak   +2 more
doaj   +5 more sources

Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP [PDF]

Journal of Translational Medicine, 2023
Background Cytoplasmic activation/proliferation-associated protein-1 (Caprin-1) is implicated in cancer cell proliferation and tumorigenesis; however, its role in the development of esophageal carcinoma (ESCA) has not been examined.
Yan Gao, Lingling Yuan, Changbin Ke, Zhijun Pei, Xiaobo Liu, Ruimin Wu, Xueyan Kui, Yanmin Zhang   +7 more
doaj   +4 more sources

β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1 [PDF]

Nature Communications
β-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder caused by mutations in the WDR45 gene, yet its molecular mechanisms remain poorly understood.
Yin Li, Jie Fang, Yuqi Ding, Xilong Zhang, Ying Liu, Wanting Qiu, He Xu, Yunzhe Kang, Jiayu Chen, Yanyan Gao, Yan G. Zhao, Peiguo Yang, Bo Wang, Wenmin Tian, Yang Chen, Wenjian Bi, Peipei Zhang   +16 more
doaj   +3 more sources

Yin and Yang Regulation of Stress Granules by Caprin-1 [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2022
Stress granules (SGs) are cytoplasmic biomolecular condensates containing proteins and RNAs in response to stress. Ras-GTPase–activating protein binding protein 1 (G3BP1) is a core SG protein. Caprin-1 and ubiquitin specific peptidase 10 (USP10) interact with G3BP1, facilitating and suppressing SG formation, respectively.
Haining Zhu, Chaowei Shi, Weimin Gong
exaly   +4 more sources

Macrophage polarization-associated lnc-Ma301 interacts with caprin-1 to inhibit hepatocellular carcinoma metastasis through the Akt/Erk1 pathway [PDF]

Cancer Cell International, 2021
Background Epithelial–mesenchymal transition (EMT) promotes migration, invasion, and metastasis of hepatocellular carcinoma (HCC) cells. The molecular mechanisms behind EMT and metastasis in HCC remain unclear.
Hong-Lin Luo, Tao Luo, Jun-Jie Liu, Fei-Xiang Wu, Tao Bai, Chao Ou, Jie Chen, Le-Qun Li, Jian-Hong Zhong   +8 more
doaj   +2 more sources

Emerging evidence of targeting non-oncogenic drivers for gastric cancer: Claudin18.2 and beyond [PDF]

Therapeutic Advances in Medical Oncology
Human epidermal growth factor receptor 2 was the first successful molecular target in treating gastric cancer, marking a significant milestone for targeted therapies.
Kazumasa Yamamoto, Izuma Nakayama, Kohei Shitara   +2 more
doaj   +2 more sources