Inhibition and Formation of Amyloid Fibrils in the Bulk and at the Interface of Biomolecular Condensates. [PDF]
Angew Chem Int Ed EnglIn this review, we discuss how biomolecular condensates can inhibit amyloid aggregation in their interior, while still facilitating fibril formation at the interface between the dense and dilute phases, where molecular and mesoscale properties are likely optimal to promote protein aggregation.
Papp M, Morelli C, Khawaja S, Arosio P.
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Emerging evidence of targeting non-oncogenic drivers for gastric cancer: Claudin18.2 and beyond [PDF]
Therapeutic Advances in Medical OncologyHuman epidermal growth factor receptor 2 was the first successful molecular target in treating gastric cancer, marking a significant milestone for targeted therapies.
Kazumasa Yamamoto +2 more
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Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities. [PDF]
Kaohsiung J Med SciABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Ndzinisa M, Altaye BM, Sher YP.
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Yin and yang regulation of stress granules by Caprin-1 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Chaowei Shi, Weimin Gong, Lin Yang
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The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection [PDF]
Journal of VirologyStress granules (SGs) are dynamic, cytoplasmic foci that form in response to environmental stresses, including viral infections, and function to restore cellular homeostasis by regulating mRNA translation, storage, and decay.
Ayisha A. Lavender +6 more
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Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
Cancer Research Communications, 2023 Ke Jiang +2 more
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Crystal structure of a dimerization domain of human Caprin-1: insights into the assembly of an evolutionarily conserved ribonucleoprotein complex consisting of Caprin-1, FMRP and G3BP1 [PDF]
Acta Crystallographica Section D: Structural Biology, 2016 Xiaolan Huang
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Bacterial expression and preliminary crystallographic studies of a 149-residue fragment of human Caprin-1 [PDF]
Acta Crystallographica Section F, Structural Biology Communications, 2015 Xiaolan Huang
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Crystal structure of a dimerization domain of human Caprin-2: similar overall dimeric fold but different molecular surface properties to that of human Caprin-1 [PDF]
Journal of Biomolecular Structure and Dynamics, 2019 Xia Zhou, Xiaolan Huang
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Relevance of miR-223 as Potential Diagnostic and Prognostic Markers in Cancer
Biology, 2022 In 1993, the discovery of microRNAs in Caenorhabditis elegans (C. elegans) altered the paradigmatic view of RNA biology and post-transcriptional gene regulation. Further study revealed the role of microRNAs in disease development and progression.
Faisal Aziz +3 more
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