Results 51 to 60 of about 8,566,253 (298)
ChemistryEuropeDinucleoside tetraphosphates (Np4N) have been reported as 5′ caps of RNAs in bacteria and mammalian cells. The guanosine‐based version (Gp4N) resembles the canonical eukaryotic 5′ cap (m7Gp3N), which is a central platform for cap‐interacting proteins ...
Cedrik Kühling +5 more
doaj +1 more source
The effects of an intensive outpatient treatment for PTSD
European Journal of PsychotraumatologyIntroduction: Research has shown that combining different evidence-based PTSD treatments for patients with PTSD in an intensive inpatient format seems to be a promising approach to enhance efficiency and reduce generally high dropout rates.Objective: To ...
Suzy J. M. A. Matthijssen +2 more
doaj +1 more source
DIAGNOSIS AND TREATMENT OF PATIENTS WITH CRYOPYRIN-ASSOCIATED PERIODIC SYNDROME
Вопросы современной педиатрии, 2015 Cryopyrin-Associated Periodic Syndrome (CAPS) refers to a group of autoinflammatory diseases and is caused by autosomal dominant mutations of the NLRP3 gene coding.
A. L. Kozlova +3 more
doaj +1 more source
Rapid wastage of the Hazen Plateau ice caps, northeastern Ellesmere Island, Nunavut, Canada [PDF]
The Cryosphere, 2017 Two pairs of small stagnant ice bodies on the Hazen Plateau of northeastern Ellesmere Island, the St. Patrick Bay ice caps and the Murray and Simmons ice caps, are rapidly shrinking, and the remnants of the St.
M. C. Serreze +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Desinstitucionalização e a prática nos Centros de Atenção Psicossocial (CAPS): a percepção dos profissionais de Santa Catarina [PDF]
, 2011 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Saúde Coletiva, Florianópolis, 2011Trata-se de uma pesquisa de abordagem qualitativa, caracterizada como exploratória e descritiva ...
Martinhago, Fernanda
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
CAPS-5 intervjuu adapteerimine eesti keelde: pilootprojekt [PDF]
, 2019 The aim of the current Bachelor’s thesis was to produce a comprehensible Estonian version of the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), as part of a more extensive adaptation process. To achieve this objective, the original English version
Tammes, Kristina
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