Results 91 to 100 of about 3,771,869 (289)
Advanced Science, EarlyView.A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan +7 more
wiley +1 more source
West Nile Virus Capsid Protein Interacts With Biologically Relevant Host Lipid Systems [PDF]
, 2019 West Nile and dengue viruses are closely related flaviviruses, originating mosquito-borne viral infections for which there are no effective and specific treatments.
Nuno C. Santos +9 more
core +1 more source
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source
Structures of HIV-1 capsid, hexamer, pentamer, and capsid protein.
, 2018 (A) The whole structure of an HIV-1 capsid. Hexamers and pentamers are colored light-orange and red, respectively. (D) Structure of the capsid protein. A hexamer structure is shown in (B) the top view and (E) the front view. A pentamer structure is shown
Hyuntae Na (814472), Guang Song (733747)
core +1 more source
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Advanced Science, EarlyView.Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang +4 more
wiley +1 more source
Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication [PDF]
, 2018 Cryo-electron microscopy reveals the structure of the Kaposi’s sarcoma-associated herpesvirus capsid, and experiments with polypeptides that mimic the smallest capsid protein demonstrate the potential for structure-derived insights to help to develop ...
Hanyoung Lim +15 more
core +1 more source
Structural insights into scaffold-guided assembly of the Pseudomonas phage D3 capsid
Nature CommunicationsTailed bacteriophages comprise the largest structural family of viruses with close relatives in archaea and the eukaryotic herpesviruses. The common assembly pathway produces an icosahedrally symmetric protein shell, called capsid, into which the double ...
Anna K. Belford +4 more
doaj +1 more source
The molecular basis of mouse adaptation by human enterovirus 71 [PDF]
, 2008 A mouse-adapted strain of human enterovirus 71 (HEV71) was selected by serial passage of a HEV71 clinical isolate (HEV71-26M) in Chinese hamster ovary (CHO) cells (CHO-26M) and in newborn BALB/c mice (MP-26M).
Chua, B.H. +4 more
core
Structural and Functional Properties of the Capsid Protein of Dengue and Related Flavivirus
, 2019 Dengue, West Nile and Zika, closely related viruses of the Flaviviridae family, are an increasing global threat, due to the expansion of their mosquito vectors.
Nuno C. Santos +15 more
core +1 more source