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CAPSULAR POLYSACCHARIDES OF SERRATIA MARCESCENS
Canadian Journal of Biochemistry, 1965Four polysaccharides were isolated from the capsular layer of Serratia marcescens cells grown on a sucrose medium. In composition, electrophoretic behavior, and sedimentation in the ultracentrifuge, all were shown to be markedly different. Analytical data indicated that the polysaccharides were an acidic glucomannan (I), a rhamnoglucan (II), a ...
Adams, G.A., Young, Robert
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Purification of Capsular Polysaccharide
2003Meningococcus is an aerobic, fastidious, Gram-negative diplococcus that is found only in humans. Its cell wall has a cytoplasmic membrane, a peptidoglycan layer, and an outer membrane. Meningococci isolated from the bloodstream or the spinal fluid are almost always encapsulated.
Yang, Qingling, Jennings, Harold
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Metabolic engineering of capsular polysaccharides
Emerging Topics in Life Sciences, 2018With rising concerns about sustainable practices, environmental complications, and declining resources, metabolic engineers are transforming microorganisms into cellular factories for producing capsular polysaccharides (CPSs). This review provides an overview of strategies employed for the metabolic engineering of heparosan, chondroitin, hyaluronan ...
Asher, Williams +2 more
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Capsular Polysaccharides of Cryptococcus neoformans
Clinical Infectious Diseases, 1984Polysaccharides of Cryptococcus neoformans are considered to have a role in the virulence of this encapsulated fungus. The structure has been determined for the most abundant polysaccharide, a glucuronoxylomannan of varying xylose and ester content. The structural complexity of the capsular material increases from serotype D to A to B to C, but even ...
A K, Bhattacharjee +2 more
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Capsular polysaccharide vaccines today
Infection, 1984Polysaccharide (PS) vaccines are a relatively new class of antibacterial vaccines that have special advantages but also special problems related to their character. Several of them have proven very effective in preventing bacteremic infections caused by encapsulated bacteria such as meningococci, pneumococci and Haemophilus influenzae type b ...
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Regulation of Cryptococcal Capsular Polysaccharide by Iron
Journal of Infectious Diseases, 1993Iron is tightly controlled in mammalian tissues and regulates virulence factors in various pathogenic organisms. The influence of Fe availability upon production of cryptococcal capsular polysaccharide was studied. Polysaccharide, measured as cell-bound glucuronyl residues, increased more than threefold as available Fe in the culture medium was varied ...
S E, Vartivarian +5 more
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Capsular Polysaccharides as Vaccine Candidates
1990The discovery of a “specific soluble substance” secreted by pneumococci during growth (Dochez and Avery 1917) and the identification of this substance as a carbohydrate (Heidelberger and Avery 1923) were new and important developments in vaccine technology.
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Capsular Polysaccharides as Human Vaccines
1983Publisher Summary This chapter discusses the use of capsular polysaccharides as human vaccines. Vaccination has proved to be one of the most useful scientific developments in the control and eradication of human disease. Early vaccines were based on whole-organism preparations or on protein toxins isolated from different bacteria.
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The K1 Capsular Polysaccharide of Escherichia coli
Clinical Infectious Diseases, 1988Epidemiologic, immunologic, and genetic evidence indicate that the K1 capsular polysaccharide confers invasiveness to Escherichia coli. The capsule, an alpha-2----8-linked homopolymer of sialic acid (NeuNAc), provides the bacterium with a physical antiphagocytic barrier. Structural similarities between K1 and human tissue components suggest that immune
R P, Silver, W, Aaronson, W F, Vann
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Bacterial Capsular Polysaccharide and Sugar Transferases
2004Capsular polysaccharides (CPs) of several pathogenic bacteria are thought to be good materials for the development of new therapeutic reagents. These polysaccharides can be used as vaccines against infection of pathogenic bacteria and are also useful as inhibitors for disease caused by aberrant and abnormal cell-cell interaction, such as cancer ...
Katsuhide, Miyake, Shinji, Iijima
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