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Regulation of Cryptococcal Capsular Polysaccharide by Iron
Journal of Infectious Diseases, 1993Iron is tightly controlled in mammalian tissues and regulates virulence factors in various pathogenic organisms. The influence of Fe availability upon production of cryptococcal capsular polysaccharide was studied. Polysaccharide, measured as cell-bound glucuronyl residues, increased more than threefold as available Fe in the culture medium was varied ...
S E, Vartivarian +5 more
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Capsular Polysaccharides as Vaccine Candidates
1990The discovery of a “specific soluble substance” secreted by pneumococci during growth (Dochez and Avery 1917) and the identification of this substance as a carbohydrate (Heidelberger and Avery 1923) were new and important developments in vaccine technology.
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Capsular Polysaccharides as Human Vaccines
1983Publisher Summary This chapter discusses the use of capsular polysaccharides as human vaccines. Vaccination has proved to be one of the most useful scientific developments in the control and eradication of human disease. Early vaccines were based on whole-organism preparations or on protein toxins isolated from different bacteria.
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The K1 Capsular Polysaccharide of Escherichia coli
Clinical Infectious Diseases, 1988Epidemiologic, immunologic, and genetic evidence indicate that the K1 capsular polysaccharide confers invasiveness to Escherichia coli. The capsule, an alpha-2----8-linked homopolymer of sialic acid (NeuNAc), provides the bacterium with a physical antiphagocytic barrier. Structural similarities between K1 and human tissue components suggest that immune
R P, Silver, W, Aaronson, W F, Vann
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Assembly of Bacterial Capsular Polysaccharides and Exopolysaccharides
Annual Review of Microbiology, 2020Polysaccharides are dominant features of most bacterial surfaces and are displayed in different formats. Many bacteria produce abundant long-chain capsular polysaccharides, which can maintain a strong association and form a capsule structure enveloping the cell and/or take the form of exopolysaccharides that are mostly secreted into the immediate ...
Chris, Whitfield +2 more
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Genetics of Capsular Polysaccharide Production in Bacteria
1990A feature of many bacteria of diverse genera is the production of extracellular acidic polysaccharides. These polysaccharides may be organised into distinct structures termed capsules, or may be excreted as an extracellular slime. However, this distinction is arbitrary and in practice may be of no functional significance.
G J, Boulnois, I S, Roberts
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Bacterial capsular polysaccharides and exopolysaccharides
2010Bacteria often produce an external layer of polysaccharides, characterized by a definite primary structure, which in turn is responsible for sometimes remarkable physicochemical properties. Although the number of monosaccharides which constitute the polymers is rather low, the great number of different polysaccharides defined up to now shows the ...
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The assay of pneumococcal capsular polysaccharide by immunodiffusion
Journal of Immunological Methods, 1974Abstract A simple gel diffusion technique was compared with the quantitative precipitin test for evaluating concentrations of pneumococcal polysaccharide. The analysis showed that results with unknown samples compared closely by the two methods.
R K, Porschen, E R, Kennedy
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Bacterial Capsular Polysaccharide and Sugar Transferases
2004Capsular polysaccharides (CPs) of several pathogenic bacteria are thought to be good materials for the development of new therapeutic reagents. These polysaccharides can be used as vaccines against infection of pathogenic bacteria and are also useful as inhibitors for disease caused by aberrant and abnormal cell-cell interaction, such as cancer ...
Katsuhide, Miyake, Shinji, Iijima
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Chemically Modified Capsular Polysaccharides as Vaccines
1988Capsular polysaccharides have assumed an important role as vaccines against disease caused by bacteria in humans. The concept of using pure definable polysaccharides devoid of their accompanying complex bacterial mass is technically elegant and is obviously capable of extension into other areas of immunoprophylaxis.
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