Results 201 to 210 of about 1,204,001 (222)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Different gut microbiome dysbioses impact the evolutionary fate of hypervirulent Klebsiella pneumoniae

iMeta, EarlyView.
Transient exposure to ampicillin results in restructuring of microbiota to favor oxygen‐tolerant bacteria, whereas osmotic laxative perturbation preserves Bacteriodota. Ampicillin‐ but not laxative‐exposed environment favors establishment of rmpA phase variants that lost hypermucoviscosity but short‐chain fatty acids present in the laxative‐exposed gut
Carey Lim, Jialing Zheng, Guoxiang Cheam, Melvin Yong, Hanrong Chen, Andrew Ting, Yahua Chen, Qingqing Wang, Niranjan Nagarajan, Yunn‐Hwen Gan   +9 more
wiley   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Redox‐Associated Renal and Male Reproductive Alterations Following Dexamethasone Exposure in Male Rats: Histopathological and Spermatological Evaluations

Journal of Applied Toxicology, EarlyView.
ABSTRACT Dexamethasone (DEX) is widely used in clinical practice, although it may also cause oxidative stress–related damage in different tissues, including the kidney and male reproductive system. This study investigated DEX‐induced renal and reproductive injury in rats and evaluated the modulatory effect of reduced glutathione on DEX‐associated redox
Caner Öztürk, Neşe Hayat Aksoy, Erkan Özkan, Ayşe Ikinci Keleş, Ahmet Karabulut   +4 more
wiley   +1 more source

Insect communities of late Pleistocene steppe–tundra and Holocene boreal forest ecosystems in central Yukon Territory, Canada

Journal of Quaternary Science, EarlyView.
ABSTRACT Subfossil insect communities from the Quartz Creek site provide a detailed record of both Late Pleistocene steppe–tundra and Holocene boreal forest ecosystems in central Yukon Territory, Canada. Fifteen Pleistocene assemblages (marine isotope stages [MIS] 4 to 2) are dominated by steppe–tundra and dry‐tundra taxa, particularly the weevils ...
Scott L. Cocker, Svetlana Kuzmina, Nick Schafstall, Michael A. Monzon, Duane G. Froese   +4 more
wiley   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

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Surgical outcomes of modified capsular tension ring and intraocular lens implantation in Marfan syndrome with ectopia lentis

European Journal of Ophthalmology, 2022
Yongxiang Jiang, Michael Deng, Jiahui Chen   +2 more
exaly  

Can toric IOL rotation be minimized? Toric IOL-Capsular Tension Ring suturing technique and its clinical outcomes

Seminars in Ophthalmology, 2022
Fikret Uçar, Muammer Ozcimen
exaly  

Propensity-matched comparison of postoperative stability and visual outcomes of toric intraocular lens with or without a capsular tension ring and updated meta-analysis

Graefe's Archive for Clinical and Experimental Ophthalmology, 2022
Xiao Yan Han, Jin Yang, Jianfeng Luo
exaly  

Combined Special Capsular Tension Ring and Toric IOL Implantation for Management of Astigmatism and High Axial Myopia with Cataracts

Seminars in Ophthalmology, 2018
Jiaxin Li, Siquan Zhu
exaly