Results 71 to 80 of about 859,375 (386)

Cell envelope defects of different capsule‐null mutants in K1 hypervirulent Klebsiella pneumoniae can affect bacterial pathogenesis

open access: yesMolecular Microbiology, 2020
Hypervirulent Klebsiella pneumoniae (hvKP) causes Klebsiella‐induced liver abscess. Capsule is important for the pathogenesis of Klebsiella in systemic infection, but its role in gut colonisation is not well understood. By generating ΔwcaJ, Δwza and Δwzy
Y. Tan   +4 more
semanticscholar   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Transcriptional Heterogeneity of Cryptococcus gattii VGII Compared with Non-VGII Lineages Underpins Key Pathogenicity Pathways

open access: yesmSphere, 2018
Cryptococcus gattii is a pathogenic yeast of humans and other animals which causes disease predominantly in immunocompetent hosts. Infection begins when aerosolized yeast or spores enter the body, triggering an immune response, including engulfment by ...
Rhys A. Farrer   +8 more
doaj   +1 more source

HP-Capsule: Unsupervised Face Part Discovery by Hierarchical Parsing Capsule Network [PDF]

open access: yesarXiv, 2022
Capsule networks are designed to present the objects by a set of parts and their relationships, which provide an insight into the procedure of visual perception. Although recent works have shown the success of capsule networks on simple objects like digits, the human faces with homologous structures, which are suitable for capsules to describe, have ...
arxiv  

Identification of Klebsiella capsule synthesis loci from whole genome data

open access: yesbioRxiv, 2016
Background Klebsiella pneumoniae and close relatives are a growing cause of healthcare-associated infections for which increasing rates of multi-drug resistance are a major concern.
K. Wyres   +6 more
semanticscholar   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Motion and deformation of capsules flowing through a corner in the inertial and non-inertial regimes [PDF]

open access: yesarXiv, 2023
We investigate the inertial and non-inertial dynamics of three-dimensional elastic capsules flowing through a square channel presenting a sharp corner. Our study analyzes the trajectory, surface area, velocity and membrane stress of the capsules in the case of a single capsule, a system of two interacting capsules and a train of ten capsules released ...
arxiv  

Comparative genome analysis identifies few traits unique to the Escherichia coli ST131 H30Rx clade and extensive mosaicism at the capsule locus [PDF]

open access: yes, 2014
Background: E.coli ST131 is a globally disseminated clone of multi-drug resistant E. coli responsible for that vast majority of global extra-intestinal E. coli infections.
Alqasim, A   +3 more
core   +2 more sources

A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity

open access: yesmBio, 2019
Klebsiella pneumoniae continues to be a substantial public health threat due to its ability to cause health care-associated and community-acquired infections combined with its ability to acquire antibiotic resistance.
K. Walker   +8 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

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