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Clinical Pharmacology and Therapeutics, 1982
Captopril, an angiotensin-converting enzyme inhibitor with antihypertensive properties, was given by mouth and intravenously in 10-mg doses to five healthy subjects. After intravenous dosing, semilogarithmic plots of captopril blood levels : time showed a triexponential decay. Data were analyzed using an open three-compartment model. The average volume
K L, Duchin +4 more
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Captopril, an angiotensin-converting enzyme inhibitor with antihypertensive properties, was given by mouth and intravenously in 10-mg doses to five healthy subjects. After intravenous dosing, semilogarithmic plots of captopril blood levels : time showed a triexponential decay. Data were analyzed using an open three-compartment model. The average volume
K L, Duchin +4 more
openaire +2 more sources
The FASEB Journal, 2003
Over the past few years, and particularly recently, there has been a goodly amount of discussion in the press about the discovery and development of highly successful drugs by the pharmaceutical industry, in which extensive data generated by government-sponsored research is claimed to have played a significant role in the industry’s success.
Charles G, Smith, John R, Vane
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Over the past few years, and particularly recently, there has been a goodly amount of discussion in the press about the discovery and development of highly successful drugs by the pharmaceutical industry, in which extensive data generated by government-sponsored research is claimed to have played a significant role in the industry’s success.
Charles G, Smith, John R, Vane
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JAMA: The Journal of the American Medical Association, 1984
To the Editor.— In the Jan 20 issue ofThe Journal, Dr Zatuchni 1 reports a case of pericarditis that he contends was caused by captopril therapy. There are several points that must be made. The author's case presentation is incomplete. Only in the last sentence does he state that "the serum urea nitrogen level continued to rise." How high was this ...
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To the Editor.— In the Jan 20 issue ofThe Journal, Dr Zatuchni 1 reports a case of pericarditis that he contends was caused by captopril therapy. There are several points that must be made. The author's case presentation is incomplete. Only in the last sentence does he state that "the serum urea nitrogen level continued to rise." How high was this ...
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2000
Abstract Captopril is an angiotensin-converting enzyme (ACE) in hibitor widely used in treatment of essential hypertension. It is considered safe and effective; principal systemic toxic reactions center around sudden decreases in blood pressure associated with commencement of therapy.
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Abstract Captopril is an angiotensin-converting enzyme (ACE) in hibitor widely used in treatment of essential hypertension. It is considered safe and effective; principal systemic toxic reactions center around sudden decreases in blood pressure associated with commencement of therapy.
openaire +1 more source

