Results 181 to 190 of about 14,957,077 (381)

324 Network-guided approach to engineering TF perturbations that synergize to counter the pathways of CAR-T cell dysfunction [PDF]

Rangapriya Sundararajan, Jeshua Malroy, Pablo García-Díaz, Glenna Foight   +3 more
openalex   +1 more source

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

Science Translational Medicine, 2017
D. O’Rourke, M. Nasrallah, A. Desai, J. Melenhorst, K. Mansfield, J. Morrissette, M. Martinez-Lage, S. Brem, E. Maloney, A. Shen, R. Isaacs, S. Mohan, G. Plesa, S. Lacey, J. Navenot, Zhaohui Zheng, B. Levine, H. Okada, C. June, J. Brogdon, M. Maus   +20 more
semanticscholar   +1 more source

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

Nature, 2022
J. Melenhorst, Gregory M. Chen, Meng Wang, D. Porter, Changya Chen, McKensie A. Collins, Peng Gao, S. Bandyopadhyay, Hongxing Sun, Ziran Zhao, Stefan Lundh, Iulian Pruteanu-Malinici, Christopher L. Nobles, Sayantan Maji, N. Frey, S. Gill, A. Loren, Lifeng Tian, I. Kulikovskaya, Minnal Gupta, David E. Ambrose, M. Davis, J. Fraietta, J. Brogdon, R. Young, A. Chew, B. Levine, D. Siegel, Cécile Alanio, E. Wherry, F. Bushman, S. Lacey, K. Tan, C. June   +33 more
semanticscholar   +1 more source

Introducing Pure Calcium Orthophosphate Gels and Aerogels

Advanced Functional Materials, EarlyView.
The synthesis of calcium phosphate‐based gels and aerogels is reported, which exhibit highly porous structures built up of networks of nanoparticles. In case of amorphous aerogels, this leads to yet unmatched specific BET surface areas, making these materials especially interesting for biomedical applications.
Oliver Jeske, Dominik Zanker, Nina Ehlert, Bing‐Qiang Lu, Denis Gebauer   +4 more
wiley   +1 more source

CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity

Frontiers in Immunology
Chimeric Antigen Receptor (CAR)-T cell therapy has rapidly emerged as a groundbreaking approach in cancer treatment, particularly for hematologic malignancies. However, the application of CAR-T cell therapy in solid tumors remains challenging.
Yaojie Kong, Jingyao Li, Xueyao Zhao, Yanwei Wu, Liang Chen   +4 more
doaj   +1 more source

Recent advances and discoveries in the mechanisms and functions of CAR T cells

Nature Reviews. Cancer, 2021
R. Larson, M. Maus
semanticscholar   +1 more source

Electron–Matter Interactions During Electron Beam Nanopatterning

Advanced Functional Materials, EarlyView.
This article reviews the electron–matter interactions important to nanopatterning with electron beam lithography (EBL). Electron–matter interactions, including secondary electron generation routes, polymer radiolysis, and electron beam induced charging, are discussed.
Camila Faccini de Lima, Prathiba Thamizhavel, Taylor J. Woehl   +2 more
wiley   +1 more source

Protocol for a mixed-methods study to develop and feasibility test a digital system for the capture of patient-reported outcomes (PROs) in patients receiving chimeric antigen receptor T-cell (CAR-T) therapies (the PRO-CAR-T study) [PDF]

Sarah Hughes, Christel McMullan, Olalekan Lee Aiyegbusi, Karen Shaw, Francesca Kinsella, Paul Ferguson, Foram Khatsuria, David Burns, Lester Pyatt, John Ansell, Evelyn Chakera, Julie Richardson-Abraham, Alastair K. Denniston, Elin Haf Davies, Charles Craddock, Melanie Calvert   +15 more
openalex   +1 more source

Broadband, Flexible, Skin‐Compatible Carbon Dots/Graphene Photodetectors for Wearable Applications

Advanced Functional Materials, EarlyView.
Broadband, flexible photodetectors integrating nitrogen‐rich carbon dots with single‐layer graphene on plastic substrates are demonstrated. A biocompatible chitosan–glycerol electrolyte enables efficient low‐voltage gating and on‐skin operation. The devices exhibit ultraviolet‐to‐near‐infrared response, mechanical robustness under bending, and verified
Nouha Loudhaief, Petr Rozhin, Ilaria Bertuol, Ali Raza, Leonardo Viti, Subhankar Roy, Enrico Cavarzerani, Luca Sbuelz, Matteo Brilli, Andrea Serinolli, Jacopo Nicoletti, Riccardo Piccoli, Sebastián Castilla, Simone Dal Zilio, Enrique Rodríguez‐Castellón, Miriam Serena Vitiello, Maurizio Selva, Flavio Rizzolio, Alvise Perosa, Giovanni Antonio Salvatore, Domenico De Fazio   +20 more
wiley   +1 more source

Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells.

Cancer Discovery, 2017
J. Gust, K. Hay, K. Hay, L. Hanafi, Daniel H. Li, D. Myerson, D. Myerson, L. Gonzalez-Cuyar, Cecilia C S Yeung, C. Yeung, W. Liles, M. Wurfel, José A López, Junmei Chen, D. Chung, Susanna Harju-Baker, Tahsin Özpolat, Kathleen R. Fink, S. Riddell, S. Riddell, D. Maloney, D. Maloney, C. Turtle, C. Turtle   +23 more
semanticscholar   +1 more source