Results 321 to 330 of about 14,957,077 (381)

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Introducing CAR-T Therapy in Kazakhstan: Establishing Academic-Scale Lentiviral Vector and CAR-T Cell Production. [PDF]

Biomolecules
Keyer V, Kydyrbayeva A, Kulatay T, Zauatbayeva G, Bazhenov D, Ingirbay B, Shakhmanova Z, Zhumabekova M, Ospanova M, Shustov AV.   +9 more
europepmc   +1 more source

Supplementary Table S5 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function

Paul Renauer, Jonathan J. Park, Meizhu Bai, Arianny Acosta, Won‐Ho Lee, Guang Han Lin, Yueqi Zhang, Xiaoyun Dai, Guangchuan Wang, Youssef Errami, Terence Wu, Paul Clark, Lupeng Ye, Quanjun Yang, Sidi Chen   +14 more
openalex   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

A novel fourth generation of CAR-T cells: CD19 CAR-T cells engineered to express membrane-bound interleukin-15 and CXCR5 for the treatment of lymphoma. [PDF]

Clin Exp Med
Cao X, Liu J, Zhao M, Guo S, Zhang M, Zhang X, Sun R, Zhao Y, Guo R, Zhang Y, Zhao M.   +10 more
europepmc   +1 more source

Figure S9 from CAR T Cells Engineered to Secrete IFNκ Induce Tumor Ferroptosis via an IFNAR/STAT1/ACSL4 Axis

Yaoxin Gao, Shasha Liu, Yifan Huang, Hui Wang, Yuyu Zhao, Xuyang Cui, Yajing Peng, Feng Li, Yi Zhang   +8 more
openalex   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Challenges and strategies in clinical applications of CAR-T therapy for autoimmune diseases. [PDF]

J Hematol Oncol
Chen X, Liu K, Liu B, Li S, Wang Y, Du X, Weng J, Song B, Wu K, Lai P.   +9 more
europepmc   +1 more source

CAR-T cells in solid tumors: Challenges and breakthroughs

Giulia Escobar, Trisha R. Berger, Marcela V. Maus   +2 more
openalex   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source