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CAR Intrinsic Design Pre-Shapes Transcriptional and Metabolic Networks in CAR T Cells. [PDF]
MetabolitesAgac Cobanoglu D +4 more
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Autoantibody origins in lupus and in relapse post CAR-T therapy
Grenov A +12 more
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Neurosurgery Clinics of North America, 2021
Chimeric antigen receptor T (CAR-T) cells, an immunotherapy that demonstrates marked success in treatment of hematologic malignancies, are an emergent therapeutic for patients with glioblastoma (GBM). GBM CAR-T trials have focused on targeting well-characterized antigens in the pathogenesis of GBM.
Thilan, Tudor +2 more
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Chimeric antigen receptor T (CAR-T) cells, an immunotherapy that demonstrates marked success in treatment of hematologic malignancies, are an emergent therapeutic for patients with glioblastoma (GBM). GBM CAR-T trials have focused on targeting well-characterized antigens in the pathogenesis of GBM.
Thilan, Tudor +2 more
openaire +2 more sources
2020
In 1891, Dr. William B. Coley, an American surgeon, made a compelling observation that immune system can be triggered to shrink tumors. The quest to exploit the power of immunotherapy however was forestalled by an era of chemotherapy that ensued.
Ranjit, Nair, Jason, Westin
openaire +3 more sources
In 1891, Dr. William B. Coley, an American surgeon, made a compelling observation that immune system can be triggered to shrink tumors. The quest to exploit the power of immunotherapy however was forestalled by an era of chemotherapy that ensued.
Ranjit, Nair, Jason, Westin
openaire +3 more sources
Onkologische Pflege, 2020
Die CAR-T-Zell-Therapie ist eine Immuntherapie, bei der körpereigene T-Zellen entnommen, gentechnisch verändert und dem Körper anschließend wieder zugeführt werden, um dann die Tumoroberfläche zu erkennen und die Tumorzelle zu zerstören. Häufig auftretende Nebenwirkungen sind Zytokinsturm und Neurotoxizität, die eine engmaschige Überwachung der ...
Barbara Huber, Chrissoula Kiote-Schmidt
openaire +1 more source
Die CAR-T-Zell-Therapie ist eine Immuntherapie, bei der körpereigene T-Zellen entnommen, gentechnisch verändert und dem Körper anschließend wieder zugeführt werden, um dann die Tumoroberfläche zu erkennen und die Tumorzelle zu zerstören. Häufig auftretende Nebenwirkungen sind Zytokinsturm und Neurotoxizität, die eine engmaschige Überwachung der ...
Barbara Huber, Chrissoula Kiote-Schmidt
openaire +1 more source
CAR-T cell therapy for cancer: current challenges and future directions
Signal Transduction and Targeted TherapyChimeric antigen receptor T (CAR-T) cell therapies have transformed the treatment of relapsed/refractory (R/R) B-cell malignancies and multiple myeloma by redirecting activated T cells to CD19- or BCMA-expressing tumor cells.
I. Zugasti +9 more
semanticscholar +1 more source
CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up.
New England Journal of MedicineBACKGROUND Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis often involves long-term immune suppression.
Fabian Müller +27 more
semanticscholar +1 more source
2022
Adaptive immunotherapy has been growing as a therapeutic alternative for cancer and other diseases treatment; chimeric antigen receptor (CAR) T cells comprise a type of adaptive immunotherapy, with recombinant receptor constructs expressed in T cells to target cells expressing specific antigens, is a potential new treatment for blood cancers and solid ...
openaire +2 more sources
Adaptive immunotherapy has been growing as a therapeutic alternative for cancer and other diseases treatment; chimeric antigen receptor (CAR) T cells comprise a type of adaptive immunotherapy, with recombinant receptor constructs expressed in T cells to target cells expressing specific antigens, is a potential new treatment for blood cancers and solid ...
openaire +2 more sources