Results 51 to 60 of about 814,843 (305)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Risk assessment of PAHs in dusts from surfaces of abandoned automobiles at auto-workshops of three semi-urban areas of Eastern Nigeria: Compositional patterns and source apportionments

open access: yesEnvironmental Pollution and Management
The concentrations, sources, compositional patterns, and risk assessments of PAHs in dust on abandoned automobiles at auto-workshops in three semi urban areas were studied.
Chideraa Courage Offor   +1 more
doaj   +1 more source

ADULTEROUS BEHAVIOUR WITHIN THE CAR-OWNER COUPLE

open access: yesIATSS Research, 2008
The objective of this paper was to analyse two activities: who rents a car and why? Which households share the driving of their cars? In order to do that, the Parc-Auto (Car-Fleet) database, built from annual postal surveys conducted with a panel of 10 ...
Francis PAPON
doaj   +1 more source

Design of Driver Seat in Automobile Car

open access: yesInternational Journal of Innovative Research in Advanced Engineering
Driver seat in the automobile is an important system. There are so many parts in the driver seat which made it a complicated system. Adjustments as well as safety systems. A seat adjustment includes height adjustment, fore and aft adjustment, back recline adjustments. Safety systems include seat belts, air bags and advanced head restraints.
Ganesh Deshmukh, Prof.Bhushan Kharamkar
openaire   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

CAR Informe anual 1983

open access: yes, 1983
Le ha correspondido, a la corporación CAR, durante este tiempo una etapa particularmente dinámica e interesante. La Corporación había venido consolidándose como entidad líder en la región y modelo de entidades similares.
Corporación Autónoma Regional de Cundinamarca – CAR
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Geographical and Multi-product Linkages of Markets: Impact on Firm Equilibrium Interactions (Some Evidence from the European Car Market) [PDF]

open access: yes
This paper aims to study geographical and multi-product linkages of markets (multiple market presence) and firm behaviour interdependence as a result of such linkages existence.
Leheyda, Nina
core  

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

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