Results 101 to 110 of about 63,239 (291)

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Design of CKD_6E Electric Drive Shunting Diesel Locomotive Body

机车电传动, 2019
In order to shorten the development cycle and improve the assembly efficiency of the car body, the CKD6E electric drive shunting diesel locomotive body was developed with modular technology.
Shaoyi LI, Guofu HE, Maoguang DENG, Huanxian LI, Ke LI, Ziquan PENG   +5 more
doaj  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Virtual design of chosen car body elements

, 2011
W artykule przedstawiono metody modelowania elementów nadwozi samochodowych oraz sposób analizy wytrzymałościowej wybranej konstrukcji. Na przykładzie podłużnic samochodowych zaprezentowano współczesny proces projektowania nadwozia samochodowego.The ...
Lewkowicz, R., Rypina, Ł., Królikowski, T., Hinz, T., Piątkowski, P.   +4 more
core  

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Prediction of the Residual Resource of the Coach Hopper-Batcher after Long Operation Taking into Account Actual Physical and Mechanical Characteristics of the Material of the Bearing Structure

Механика машин, механизмов и материалов, 2016
Procedure of prediction of a residual resource of a bearing structure of the special railway car hopper-batcher after long- term service has been developed.
Artur V. Putyato, Evgeniy N. Konovalov, Pavel M. Afanaskov   +2 more
doaj  

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, EarlyView.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source

Analysis on impedance characteristics and research on pantograph rising and dropping overvoltage of CFRP carbody

机车电传动, 2022
In order to evaluate the over-voltage damage of CFRP (Carbon fiber reinforced polymer/plastic) car body due to its poorer conductivity than traditional aluminum alloy car body, the impedance characteristics of CFRP were analyzed and tested, and the surge
XU Yue, FENG Yuming, BAI Gang, BIAN Yongliang, WANG Fuqiang, GUO Wenqing   +5 more
doaj  

STUDY ON SECONDARY OPTIMIZATION OF METRO ALUMINUM ALLOY CAR BODY BASED ON STIFFNESS CONTRIBUTION

Jixie qiangdu
In the screening of optimization design regions for subway car body structures, the sensitivity method is often used; however, its operation process is complex and cumbersome, and it cannot be quickly applied to the design of car body structures.
QIU Xinyu, LI Yana, LIU Xingyu
doaj