Results 121 to 130 of about 63,239 (291)

Vibration Damping of a Flexible Car Body Structure Using Piezo-Stack Actuators

open access: yes, 2008
The active vibration damping of a flexible car body structure can be accomplished by either active suspension schemes or actuator inputs acting directly on the car body structure.
Schirrer, Alexander   +3 more
core  

ANALYSIS OF AERODYNAMIC LOAD ON FATIGUE STRENGTH OF THE HIGH-SPEED TRAIN CAR BODY

open access: yesJixie qiangdu, 2015
According to the actual circumstance of high-speed train in line operation four aerodynamic load cases are set up: pneumatic passing each other open wire,single train passing through tunnel,two trains passing by in tunnel and cross wind.Four types of ...
SONG Ye, WU PingBo, JIA Lu
doaj  

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

open access: yesAdvanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang   +11 more
wiley   +1 more source

SIMULATION OF URBAN RAIL VEHICLE CRASH AND FACTORS INFLUNCING ANTI-CLIMBING ABILITY OF ITS ANTI-CLIMBER

open access: yesJixie qiangdu, 2015
By use of the finite element software Hypermesh and LS-DYNA,the processes were respectively simulated of urban rail vehicle head car,with and without anti-climbing energy absorption device,impacting the fixed rigid wall face to face at the speed of 12.25
CHEN ShuQin, NIU WeiZhong, WEN Tao
doaj  

Metal-hybrid structures for an improved crash behaviour of car body structures [PDF]

open access: yes, 2010
Zur Zeit verwendete Karosserien in Stahl-Schalen-Bauweise bestehen vorwiegend aus durch Punktschweißen gefügten Blechschalen. Solche Strukturen können im Crashfall, bei einer konzentrierten Lasteinleitung wie dem Pfahlcrash, zu hohen Intrusionen führen, auch da die Blechschalen konzeptbedingt zum Beulen und Falten neigen.
Kriescher, Michael   +3 more
openaire   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu   +7 more
wiley   +1 more source

Computational analysis of A-Pillar vortex formation in automotive applications [PDF]

open access: yes, 2013
The research focusses on computational analysis of vortex generation behind A-Pillar of simplified model derived from Jaguar XF that excludes air from the underside of vehicle.
Bhambra, Devinder Pal Singh
core  

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

open access: yesAdvanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas   +6 more
wiley   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

open access: yesAdvanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou   +12 more
wiley   +1 more source

Combining Fret and Super‐Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale

open access: yesAdvanced Science, EarlyView.
BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet   +5 more
wiley   +1 more source

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