Results 41 to 50 of about 1,539,435 (245)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Aproximación a la historia ambiental de la minería en Boyacá [PDF]

, 2013
Se proponen tres fases de la historia ambiental de la minería en Boyacá. Una Primera,previo la llegada del elemento hispánico, caracterizada por la explotación de arcilla y piedra para construcción de viviendas y explotación de carbón para cocción de ...
José Alfonso Avellaneda Cusaría
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Significance of the High Abundance of Pentacyclic Triterpenyl and Hopenyl Acetates in Sphagnum Peat Bogs from Northern Spain

Quaternary, 2019
Global warming is expected to increase the rate of CH4 emission from acidic peatlands leading to an increased interest on its mechanisms of formation.
Veneranda López-Días, Angeles G. Borrego, Carlos G. Blanco, Achim Bechtel, Wilhelm Püttmann   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Caracterizacion de la produccion de carbon en pequenos propietarios del sector Fundo Riquelme, Provincia de Linares, VII Region [PDF]

, 2003
82 p.El objetivo general de esta Memoria de Titulo fue estudiar la producción de carbón vegetal en pequeños propietarios del sector Fundo Riquelme, Provincia de Linares, VII región.
Araya Farias, Francisco Esteban, Ponce Donoso, Mauricio (Prof. Guia)   +1 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Carbón activado: ¿la panacea en urgencias en el paciente intoxicado?

Revista de Educaci�n e Investigaci�n en Emergencias
Las intoxicaciones con xenobióticos son comunes en el servicio de urgencias, y como tratamiento de primera línea, la descontaminación gastrointestinal sigue siendo la terapia más utilizada. De las opciones disponibles, el carbón activado, un polvo fino negro producido a partir de la pulverización y «activación» física o química de material orgánico ...
openaire   +2 more sources

New tools for extracting cork from Quercus suber L.: increasing productivity and reducing damage

Forest Systems, 2014
Aim of study: The aim of this study is to test new tools designed to debark cork oak trees: mechanized tools to perform cutting operations (IPLA-Morell, Stihl MC200 and COVELESS) and manual tools to separate and extract the cork (cork pincers, MIJURO ...
Jesus Beira Davila, Cristina Prades Lopez, Ramon Santiago Beltran   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source