Results 91 to 100 of about 69,497 (186)

Selective and Waste‐Free Isolation of High Purity Primary Amines from Amine and Reaction Mixtures by Selective Ammonium Carbamate Crystallization

Chemistry – A European Journal, Accepted Article.
The isolation of primary amines from secondary and tertiary amines presents a significant challenge in their sustainable production, and existing strategies are either multi‐step, energy‐demanding, or waste‐intensive. We present an efficient process that utilizes the distinct solubility profiles of ammonium carbamate species formed through waste‐free ...
Bernd Rienhoff, Dilara Mede, Mara Schöler, Dieter Vogt, Thomas Seidensticker   +4 more
wiley   +1 more source

Total Synthesis of Kanamycins

Chemistry – A European Journal, EarlyView.
This paper reports on creating a novel synthetic route of kanamycins A and B using the desymmetric boron‐mediated aglycon delivery (BMAD) reaction of meso‐diol acceptor with 1,2‐anhydro donor and regio‐ and stereoselective glycosylation of diol acceptor with trichloroacetimidate donor for introduction of a set of challenging 1,2‐cis‐glycosidic linkages
Kanae Hosomi, Banjo Imai, Naoto Takemura, Kazuki Senoo, Chigusa Hayashi, Masayuki Igarashi, Kazunobu Toshima, Daisuke Takahashi   +7 more
wiley   +1 more source

Strategy‐Level Prodrug Synthesis

Chemistry – A European Journal, EarlyView.
Prodrug approaches can be expanded by increasing options for controlling site‐selective functionalization, boosting the range of linking groups, and enhancing the chemoselectivity of reactive group incorporation. This Concept describes strategy‐level prodrug synthesis, whereby these issues are addressed at an early stage of a sequence.
Paul J. Geaneotes, Paul E. Floreancig
wiley   +1 more source

Asymmetric Synthesis of 1-Heteroaryl-1-arylalkyl Tertiary Alcohols and 1-Pyridyl-1-arylethanes by Lithiation-Borylation Methodology [PDF]

, 2013
Aggarwal V. K., Biradar D. B., Biradar D. B., Carstens A., Charlotte G. Watson, Chen C.-A., Cozzi P. G., Dosa P. I., García C., García C., García C., Garg D. C., Greene M. A., Hatano M., Hatano M., Hatano M., Hoppe D., Hu Q., Kanai M., Luderer M. R., Madduri A. V. R., Madduri A. V. R., Maity P., Matsunaga N., Messaoudi S., Moree W. J., Nave S., Ou L., Pathak T. P., Ramón D. J., Ramón D. J., Shi S.-L, Shibasaki M., Song S., Starck J. P., Stymiest J. L., Taylor B. L. H., Varinder K. Aggarwal, Wada R., Weber B., Yus M., Yus M.   +41 more
core   +2 more sources

Stimuli‐Responsive Prodrug Linkers That Simultaneously Release Cargo and Neutralize In Situ Generated (Aza)Quinone Methides

Chemistry – A European Journal, EarlyView.
Highly reactive (aza)quinone methides are electrophiles generated from many stimuli‐responsive prodrugs and probes. A new linker has been designed to quench the electrophilic methide, forming a tetrahydroisoquinoline (THIQ) heterocycle in high yields, even when a competing nucleophile is present.
Veera V. Shivaji R. Edupuganti, Siddharth S. Matikonda, Aggie Lawer, Jessica M. Fairhall, Harrison M. Lewin, Jui Thiang Brian Kueh, Joel D. A. Tyndall, Allan B. Gamble   +7 more
wiley   +1 more source

First Phosphonic‐Type Inhibitors and Activity‐Based Probes Specific to the O'nyong‐nyong Virus Capsid Protease

ChemMedChem, EarlyView.
The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska, Agnieszka Łupicka‐Słowik, Renata Grzywa, Yuliya Chykunova, Krzysztof Pyrć, Marcin Sieńczyk   +5 more
wiley   +1 more source

Improved C5‐Amide Bioisosteres for Human Neuraminidase 1 Inhibitors Based on 2‐Deoxy‐2,3‐Didehydro‐N‐Acetyl Neuraminic Acid

ChemMedChem, EarlyView.
This article describes the development of improved NEU1 inhibitors based on the 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid scaffold. A series of candidate inhibitors are designed containing bioisosteres of the C5‐amide group and evaluated for activity against NEU1‐4 enzymes.
Mostafa Radwan, Elisa G. Carvajal, Christopher W. Cairo   +2 more
wiley   +1 more source

Elucidating the structures of substituted adamantyl esters and ethers using rotational spectroscopy and computations

ChemPhysChem, Accepted Article.
Adamantane derivatives are promising candidates in the design of new materials with unique properties. In this study, we investigated the molecular structure of a series of adamantyl esters and ethers with an increasing substituent size using broadband rotational spectroscopy.
Nataša Burić, Donatella Loru, Jasna Alić, Marina Šekutor, Melanie Schnell, Pablo Pinacho   +5 more
wiley   +1 more source

Electrocatalytic CN Coupling: Advances in Urea Synthesis and Opportunities for Alternative Products

ChemSusChem, EarlyView.
This review explores electrocatalytic urea synthesis via carbon–nitrogen (CN) coupling from CO2 and nitrogen species, specifically nitrate, nitrite, nitric oxide, and nitrogen gas. It discusses recent discoveries in catalyst design, reaction pathways, and detection methods. Future outlooks on industrial applications, alternative CN coupling products,
Parker Ballard‐Kyle, Isabel Hsieh, Huiyuan Zhu   +2 more
wiley   +1 more source

Rethinking Chlorine: Essential Chemical or Replaceable Risk?

ChemSusChem, EarlyView.
Chlorine is essential for the production of plastics and pharmaceuticals but poses significant safety and environmental risks. Herein, processes are presented that substitute chlorine or reduce its demand. Where indispensable, trichloride‐ and bichloride‐based ionic liquids could enhance safety and streamline the integration of renewable energy ...
Johannes Schwan, Merlin Kleoff, Gesa H. Dreyhsig, Patrick Voßnacker, Traute Fiedler, Marian Rosental, Sebastian Riedel   +6 more
wiley   +1 more source