Results 171 to 180 of about 127,195 (275)

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

open access: yesSmall Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli   +6 more
wiley   +1 more source

Novel Bio‐Based Polyurethane Elastomers Customizable for Orthopedic Devices: Toughness, Rapid Degradability, and Safety

open access: yesSusMat, EarlyView.
ABSTRACT Given the increasing global demand for sustainable materials and growing concerns over the depletion of petrochemical resources, we report the synthesis of an amorphous bio‐derived polyester diol, and this diol was polymerized with various isocyanates and butanediol, yielding a novel series of bio‐based polyurethane elastomers (BPUEs). Notably,
Chenxin Xu   +9 more
wiley   +1 more source

Mechanism of Ammonia‐Induced Brain Damage in Chinese Striped‐Necked Turtle (Mauremys sinensis)

open access: yesIntegrative Zoology, EarlyView.
High levels of ammonia disrupt the integrity of the brain barrier in Mauremys sinensis, leading to tissue edema. This, in turn, triggers a series of cascade reactions, including disturbances in neurotransmitter levels, particularly glutamate, which might further exacerbate the neurotoxic effects.
Yunjuan Xiao   +6 more
wiley   +1 more source

Beyond Sexual Selection: Natural Selection Related Camouflage and Thermoregulation Shape Sexual Color Dimorphism in Diploderma Lizards

open access: yesIntegrative Zoology, EarlyView.
Integrating comparative spectrometry, image analysis, and thermal modeling, we reveal that (1) females optimize crypsis via background matching, (2) males prioritize high‐contrast disruptive patterning at a significant thermoregulatory cost (reduced solar heat gain), and (3) habitat‐specific monomorphism in Diploderma slowinskii underscores ecological ...
Yuning Cao, Lin Shi, Yin Qi
wiley   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck   +1 more
wiley   +1 more source

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