Results 81 to 90 of about 127,195 (275)

Metabolite essentiality elucidates robustness of Escherichia coli metabolism

, 2007
Complex biological systems are very robust to genetic and environmental changes at all levels of organization. Many biological functions of Escherichia coli metabolism can be sustained against single-gene or even multiple-gene mutations by using ...
Almaas, Alon, Covert, D.-Y. Lee, Gerdes, Ghim, Goebl, H. Jeong, Jeong, K. H. Lee, Kanehisa, Ma, P.-J. Kim, Papp, Raymond, Reed, S. Park, S. Y. Lee, Schmidt, Stelling, T. Y. Kim, Tong, Tucker, von Dassow   +23 more
core   +2 more sources

A Modular Biosensor Platform for the Detection of Plastic Monomers and the Engineering of Promiscuous Amidases Toward Challenging Substrates

Advanced Science, EarlyView.
A luciferase is used as biosensor for aldehydes, produced enzymatically from different monomeric building blocks of plastics like polyurethanes (PUs). The screening platform is used to monitor esterase, amidase, and urethanase activity and to guide the selection of enzyme variants with improved hydrolytic activities toward difficult to hydrolyze ...
Ina Somvilla, Hannah Meier, Florian Oehlschläger, Hannes Meinert, Lena Koch, Patrick Ihrle, Katharina M. Mehnert, Morten Flieger, Jonas Boß, Marco Seifert, Dominique Böttcher, Uwe T. Bornscheuer, Thomas Bayer   +12 more
wiley   +1 more source

Copper‐Catalyzed Three‐Component Selective 1,4‐Amino Oxygenation of 1,3‐Dienes

Angewandte Chemie, EarlyView.
Enclosed is a copper‐catalyzed selective 1,4‐amino oxgenation of 1,3‐dienes with the presence of a strong Brønsted acid. This three‐component transformation offers a novel and powerful approach to construct (E)‐1,4‐allylic amino oxygenated motifs by the simultaneous installation of structurally diverse alkylamines and alcohols directly onto 1,3‐dienes.
Guangshou Feng, Maria K. Velopolcek, Qiu Wang   +2 more
wiley   +2 more sources

Lithium and aluminium carbamato derivatives of the utility amide 2, 2, 6, 6- tetramethylpiperidide [PDF]

, 2010
Insertion of CO2 into the metal-N bond of a series of synthetically-important alkali-metal TMP (2,2,6,6-tetramethylpiperidide) complexes has been studied.
Abram, Alan R. Kennedy, Andrews, Aresta, Armstrong, Ball, Belforte, Butler, Chang, Conway, Conway, David E. Oliver, Davies, Dell'Amico, Dell'Amico, Feier-Iova, Garcia-Álvarez, Gehrhus, Habereder, Hagadorn, Hyvärinen, Inoue, Katritzky, Knabel, Knabel, Köhn, Lappert, Lucht, Maruoka, Mulvey, Mulvey, Mulvey, Naruse, Nozaki, Otero, Otero, Otero, Rathke, Remenar, Robert E. Mulvey, Sheldrick, Stuart D. Robertson, Tanaka, Tang, Vauthey, Williard, Woodcock, Wu, Yang, Yasuda, Yasuda   +50 more
core   +1 more source

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Toxicity of some biorational and conventional insecticides to cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae) and its ectoparasitoid, Habrobracon hebetor (Hymenoptera: Braconidae) [PDF]

نامه انجمن حشره‌شناسی ایران, 2008
Insect growth regulators and spinosyns which are physiologically and ecologically selective, respectively, have been investigated as replacements or complements to non-selective conventional insecticides.
M. Saber, G. Nouri-Ganbalani, M. J. Hejazi, H. Rafiee Dastjerdi   +3 more
doaj  

Tailored Organogel Systems for Optimized Pesticide Delivery: Mechanistic Insights and Agricultural Applications

Advanced Science, EarlyView.
Utilizing molecular engineering for network design, three pesticide‐loaded organogels (PLOs) carriers exhibiting varying degrees of flexibility were prepared. The mechanical properties of these carriers, tunable via their network molecular structures, enhance their structural adaptability and retention stability at biological interfaces, thereby ...
Yue Wang, SiYu Xv, Chao Wu, Nan Li, GuoPeng Teng, XuePing Huang, Jian Luo   +6 more
wiley   +1 more source

Predictive, Data‐Driven Design of Red‐Light Photoredox Catalysts for C─Heteroatom Bond Formation

Angewandte Chemie, EarlyView.
From redox numbers to red light: Donor oxidation and core reduction potentials predict E0‐0 in cyanoarene dyes, guiding selection of an efficient red‐light catalyst, 4MeODPATPN (PC13). Under 620 nm light, PC13 facilitates Ni‐catalyzed C─heteroatom cross‐couplings (C─N, C─O, C─S) with high functional‐group tolerance and reduced hydrodehalogenation ...
Amir Gizatullin, Tingting Yuan, Sascha Grotjahn, Luigi Cavallo, Burkhard König, Chen Zhu, Magnus Rueping   +6 more
wiley   +2 more sources

NGHIÊN CỨU TỔNG HỢP MỘT SỐ DẪN XUẤT UREA BẰNG PHƯƠNG PHÁP HỖ TRỢ VI SÓNG

Tạp chí Khoa học Đại học Cần Thơ, 2010
Các dẫn xuất urea được ứng dụng rộng rãi trong nhiều lĩnh vực như dược phẩm, nông nghiệp, chất phụ gia cho xăng dầu,... Hợp chất 4-nitrophenylchloroformate được biết là một tác nhân carbonyl hóa hiệu quả thay thế cho phosgene trong tổng hợp carbamate và ...
Nguyễn Thị Mỹ Đầm, Huỳnh Thị Ngọc Liên, Bùi Thị Bửu Huê   +2 more
doaj