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In vitro embryotoxicity of carbamazepine and carbamazepine-10,11-epoxide [PDF]
Teratology, 1996 Carbamazepine (Tegretol, CBZ) is an anticonvulsant drug that is very effective in the treatment of tonic-clonic seizures and is gaining acceptance as a treatment for various psychiatric disorders. The drug is embryotoxic in rodents and has been reported to produce neural tube defects in approximated 1% of prenatally exposed human offspring.
Deborah K. Hansen +3 more
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Activation of T cells by carbamazepine and carbamazepine metabolites
Journal of Allergy and Clinical Immunology, 2006T-cell-mediated hypersensitivity is a rare but serious manifestation of drug therapy.To explore the mechanisms of drug presentation to T cells and the possibility that generation of metabolite-specific T cells may provoke cross-sensitization between drugs.A lymphocyte transformation test was performed on 13 hypersensitive patients with carbamazepine ...
Stephen E. Clarke +12 more
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The pharmacokinetics of carbamazepine
European Journal of Clinical Pharmacology, 1977The time-courses of plasma carbamazepine concentrations were followed in six apparently healthy adult subjects who, at different times, took single oral drug doses of 200, 400, 500, 600, 700, 800 and 900 mg. There were some suggestions of impaired bioavailability of the drug when given in tablet form.
Mervyn J. Eadie +5 more
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2016
This chapter includes the aspects of carbamazepine. The drug is synthesized by the use of 5H-dibenz[b,f]azepine and phosgene followed by subsequent reaction with ammonia. Carbamazepine is generally used for the treatment of seizure disorders and neuropathic pain, it is also important as off-label for a second-line treatment for bipolar disorder and in ...
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This chapter includes the aspects of carbamazepine. The drug is synthesized by the use of 5H-dibenz[b,f]azepine and phosgene followed by subsequent reaction with ammonia. Carbamazepine is generally used for the treatment of seizure disorders and neuropathic pain, it is also important as off-label for a second-line treatment for bipolar disorder and in ...
openaire +4 more sources
European Respiratory Journal, 1990
A 69 yr old man was admitted with a 10 day history of fever, arthromyalgia, dyspnoea, dry cough and pleuritic pain. Temperature was 38 degrees C; tachypnoea 36 rpm. Extensive crackles were audible over both upper lung fields. Chest X-ray showed bilateral alveolar infiltrates.
B, Barreiro, F, Manresa, J, Valldeperas
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A 69 yr old man was admitted with a 10 day history of fever, arthromyalgia, dyspnoea, dry cough and pleuritic pain. Temperature was 38 degrees C; tachypnoea 36 rpm. Extensive crackles were audible over both upper lung fields. Chest X-ray showed bilateral alveolar infiltrates.
B, Barreiro, F, Manresa, J, Valldeperas
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Journal of Clinical Psychopharmacology, 1986
Dementia is an ailment that is becoming a major management problem. The presentations of dementias vary depending upon the site of lesions and their severity. Different medications have been tried to relieve some of the more common symptoms associated with the dementias.
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Dementia is an ailment that is becoming a major management problem. The presentations of dementias vary depending upon the site of lesions and their severity. Different medications have been tried to relieve some of the more common symptoms associated with the dementias.
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Carbamazepine for cocaine dependence
Cochrane Database of Systematic Reviews, 2002Cocaine dependence has become a substantial public health problem, developing a significant number of medical, psychological and social problems, including the spread of infectious diseases (e.g. AIDS, hepatitis and tuberculosis), crime, violence and neonatal drug exposure.
A R, Lima +4 more
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Carbamazepine‐10,11‐Epoxide Determined by EMIT Carbamazepine Reagent
Epilepsia, 1980SUMMARYCarbamazepine‐10,11‐epoxide (CBZ‐OX) was determined in physiological solutions by means of EMIT carbamazepine reagent. It was recognized as 12 to 20% of the total amount, the cross‐reaction being higher at lower CBZ‐OX concentrations. A correction for CBZ‐OX is necessary when one wants to correlate EMIT carbamazepine values with gas‐liquid ...
S. Piredda, F. Monaco
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