Results 1 to 10 of about 78,762 (304)
EXCLI Journal : Experimental and Clinical Sciences, 2023 Agonists of Benzodiazepine (BZD) receptor are exhaustively used in the control of muscle spasms, seizure, anxiety, and insomnia. BZDs have some unwanted effects; therefore, the development of new BZD receptor agonists with better efficacy and fewer ...
Elham Rezaee +7 more
doaj +1 more source
Salvinorin A Does Not Affect Seizure Threshold in Mice
Molecules, 2020 The κ-opioid receptor has recently gained attention as a new molecular target in the treatment of many psychiatric and neurological disorders including epilepsy.
Katarzyna Socała +2 more
doaj +1 more source
Inhibitory Effect of Eslicarbazepine Acetate and S-Licarbazepine on Nav1.5 Channels
Frontiers in Pharmacology, 2020 Eslicarbazepine acetate (ESL) is a dibenzazepine anticonvulsant approved as adjunctive treatment for partial-onset epileptic seizures. Following first pass hydrolysis of ESL, S-licarbazepine (S-Lic) represents around 95% of circulating active metabolites.
Theresa K. Leslie +5 more
doaj +1 more source
Sodium Valproate Induced Alopecia: A Case Series [PDF]
Journal of Clinical and Diagnostic Research, 2017 Drug induced alopecia may range from a barely detectable shedding to an irreversible baldness. Alopecia associated with valproate is a dose-dependent and reversible side effect.
Sereen Rose Thomson +2 more
doaj +1 more source
Neurobiology of Disease, 2014 Viral infection of the CNS can result in encephalitis and acute seizures, increasing the risk for later-life epilepsy. We have previously characterized a novel animal model of temporal lobe epilepsy that recapitulates key sequela in the development of ...
Anthony D. Umpierre +8 more
doaj +1 more source
Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor
Frontiers in Cellular Neuroscience, 2022 Epilepsy is one of the most common neurological diseases globally, resulting from a disorder in brain activity. This condition can be triggered by birth trauma, traumatic brain injury (TBI), infections of the brain and stroke. More than 70 million people
Nilton Akio Muto +6 more
doaj +1 more source
Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]
, 2018 The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique +8 more
core +2 more sources
Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor [PDF]
, 2020 In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia +3 more
core +1 more source
Timing of Anticonvulsant Administration in Status Epilepticus
Pediatric Neurology Briefs, 2015 Investigators from the Pediatric Status Epilepticus Research Group studied the time elapsed from onset of pediatric convulsive status epilepticus (SE) to administration of antiepileptic drugs (AED).
Juan A Piantino
doaj +1 more source
Bone mineral density, vitamin D and anticonvulsant therapy [PDF]
Arquivos de Neuro-Psiquiatria, 2000 The aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy. METHODS: Sixty-nine men, outpatients on chronic anticonvulsant therapy, who had been treated for at least 5 years, were ...
SILVANA FILARDI +3 more
doaj +1 more source