Results 1 to 10 of about 53,577 (300)
Pharmacokinetic Studies of Triazolyl-Oxazolidinone Derivatives with Anticonvulsant Effects in Rats [PDF]
PharmaceuticsBackground/Objectives: Five triazolyl-oxazolidinone derivatives were reported to suppress seizures in rats with different efficacies and durations of action, which may be due to different pharmacokinetic behaviors.
Mohsen A. Hedaya +5 more
doaj +2 more sources
Molecules, 2021 Rosa webbiana L. (Rosaceae) is one of the least reported and most understudied members of this family. It is native to the Himalayan regions of Pakistan and Nepal.
Anum Firdous +10 more
doaj +1 more source
Treating Epilepsy with Natural Products: Nonsense or Possibility?
Pharmaceuticals, 2023 Epilepsy is a neurological disease characterized by recurrent seizures that can lead to uncontrollable muscle twitching, changes in sensitivity to sensory perceptions, and disorders of consciousness.
Milan Malaník +5 more
doaj +1 more source
Thiazole Ring—A Biologically Active Scaffold
Molecules, 2021 Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal ...
Anthi Petrou +2 more
doaj +1 more source
Reduced Effect of Anticonvulsants on AMPA Receptor Palmitoylation-Deficient Mice
Frontiers in Pharmacology, 2021 AMPA receptors are responsible for fast excitatory synaptic transmission in the mammalian brain. Post-translational protein S-palmitoylation of AMPA receptor subunits GluA1-4 reversibly regulates synaptic AMPA receptor expression, resulting in long ...
Madoka Iizumi +4 more
doaj +1 more source
Developmental Toxicity Study of DL-4-Hydroxy-4-Phenylhexanamide (DL-HEPB) in Rats
Life, 2023 Antiepileptic drugs affect embryonic development when administered during pregnancy, generating severe alterations, such as as cleft lip, spina bifida, heart abnormalities, or neuronal alterations.
José Melesio Cristóbal-Luna +5 more
doaj +1 more source
Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Rosemary (Rosmarinus officinalis L.) is an evergreen bushy shrub which grows along the Mediterranean Sea, and sub-Himalayan areas. In folk medicine, it has been used as an antispasmodic, mild analgesic, to cure intercostal neuralgia, headaches, migraine,
Mahboobeh Ghasemzadeh Rahbardar +1 more
doaj +1 more source
Pharmaceuticals, 2021 Pregnanolone glutamate (PA-G) is a neuroactive steroid that has been previously demonstrated to be a potent neuroprotective compound in several biological models in vivo.
Eva Kudova +7 more
doaj +1 more source
Comparison of Magnesium Sulphate Protocols by Weight-Adjusted Versus Two Grams Per Hour for Preventing Convulsion in Preeclampsia: A Randomised Controlled Trial [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: Magnesium Sulphate (MgSO4 ) is the most effective drug used for seizure prevention in preeclampsia; however, the dosage of MgSO4 is still in controversy.
Saowanee Tangmanowutthikul +3 more
doaj +1 more source
European Psychiatry, 2022 Introduction The anticonvulsant m-Cl-BHM is promising for the pathogenetically directed thrapy does not cause negative effects. Objectives Investigation of the effect of m-Сl-BHM on “immunochemical homeostasis” in rats with experimental alcoholism ...
Т. Shushpanova +12 more
doaj +1 more source