Results 21 to 30 of about 84,044 (310)

Structure-Dependent Activity of Natural GABA(A) Receptor Modulators

Molecules, 2018
GABA(A) receptors are ligand-gated ion channels consisting of five subunits from eight subfamilies, each assembled in four hydrophobic transmembrane domains.
Serhat Sezai Çiçek
doaj   +1 more source

Development of the 1,2,4‐triazole‐based anticonvulsant drug candidates acting on the voltage‐gated sodium channels. Insights from in‐vivo, in‐vitro, and in‐silico studies

European Journal of Pharmaceutical Sciences, 2019
The treatment of epilepsy remains difficult mostly since almost 30% of patients suffer from pharmacoresistant forms of the disease. Therefore, there is an urgent need to search for new antiepileptic drug candidates.
B. Kaproń, J. Łuszczki, A. Płazińska, A. Siwek, T. Karcz, A. Gryboś, G. Nowak, Anna Makuch-Kocka, K. Walczak, E. Langner, Karolina Szalast, S. Marciniak, M. Paczkowska, J. Cielecka‐Piontek, L. Ciesla, T. Plech   +15 more
semanticscholar   +1 more source

Anticonvulsant Activity of Hydro Alcoholic Extract and Solvent Fractions of Biophytum umbraculum Welw. Syn (Oxalidaceae) Root in Mice

Journal of Experimental Pharmacology, 2022
Nebeyi Fisseha, Workineh Woldeselassie Hammeso, Dejen Nureye Department of Pharmacy, School of Pharmacy, College of Health Sciences, Mizan-Tepi University, Mizan-Aman, South West, EthiopiaCorrespondence: Nebeyi Fisseha, Tel +251913214835, Email ...
Fisseha N, Hammeso WW, Nureye D
doaj  

Prevalence of anticonvulsant-induced vitamin D deficiency

Эпилепсия и пароксизмальные состояния, 2022
Background. Epilepsy is a common disease in children and adults, requiring long-term or lifelong use of antiepileptic drugs (AEDs) in 60% of cases. Enzyme-inducing and enzyme-inhibiting AEDs may have a negative effect on vitamin D metabolism. However, at
E. A. Dontseva, P. I. Pilipenko, N. A. Shnayder, M. M. Petrova, R. F. Nasyrova   +4 more
doaj   +1 more source

Seizure threshold, hormones and anti epileptic drugs

Universa Medicina, 2008
The concept of seizure threshold holds that everyone has a certain balance between excitatory and inhibitory forces in the brain. A low seizure threshold makes it easier for epilepsy to develop and easier for someone to elicit single seizure.
Harsono Harsono
doaj   +1 more source

Anticonvulsant Drug Induced Cell Death in the Developing White Matter of the Rodent Brain

Epilepsia, 2016
During critical periods of brain development, both seizures and anticonvulsant medications can affect neurodevelopmental outcomes. In rodent models, many anticonvulsants trigger neuronal apoptosis.
Suhasini Kaushal, Zenab Tamer, F. Opoku, P. Forcelli   +3 more
semanticscholar   +1 more source

Cyclooxygenase-1 as a potential therapeutic target for seizure suppression: evidences from zebrafish pentylenetetrazole-seizure model

Frontiers in Neurology, 2016
Cyclooxygenases (COX) -1 and -2 are isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins (PGs). COX-2 and PGs are rapidly increased following seizures and are known to play important roles in the neuroinflammatory process.
Patricia Gonçalves Barbalho, Benilton de Sá Carvalho, Iscia Lopes-Cendes, Claudia Vianna Maurer-Morelli   +3 more
doaj   +1 more source

The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the Subunit of a Calcium Channel (*)

Journal of Biological Chemistry, 1996
Gabapentin (1-(aminomethyl)cyclohexane acetic acid; Neurontin) is a novel anticonvulsant drug, with a mechanism of action apparently dissimilar to that of other antiepileptic agents.
N. Gee, J. Brown, V. U. Dissanayake, J. Offord, Richard J. Thurlow, G. Woodruff   +5 more
semanticscholar   +1 more source

Midazolam as an anticonvulsant antidote for organophosphate intoxication− A pharmacotherapeutic appraisal

Epilepsia, 2015
This review summarizes the therapeutic potential of midazolam as an anticonvulsant antidote for organophosphate (OP) intoxication.
S. Reddy, D. Reddy
semanticscholar   +1 more source

Syntheses of Benzo[d]Thiazol-2(3H)-One Derivatives and Their Antidepressant and Anticonvulsant Effects

Marine Drugs, 2019
Thirty-four new benzo[d]thiazol derivatives 2a−2i, 3a−3r, and 4a−4g were synthesized and investigated for their potential antidepressant and anticonvulsant effects.
Qinghao Jin, Zhiyang Fu, Liping Guan, Haiying Jiang   +3 more
doaj   +1 more source