Results 1 to 10 of about 6,209 (222)

Virtual Screening and Zebrafish Phenotype-Based Evaluation Argues Against Repurposing 4-Phenylbutyrate for STXBP1-Related Disorders. [PDF]

Pharmacol Res Perspect
ABSTRACT Syntaxin‐binding protein 1 (STXBP1) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18‐1 (STXBP1) C. elegans models demonstrate that 4‐phenylbutyrate (4‐PBA) or related pharmacological chaperones stabilize ...
Frick A, Whyte-Fagundes P, Baraban SC.
europepmc   +2 more sources

Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABA_A Receptor and Voltage-Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies. [PDF]

Brain Behav
Citronellal, daidzin, and phytol exert significant anticonvulsant effects in a chick seizure model by enhancing GABAergic transmission and blocking voltage‐gated sodium channels, with combination therapies showing enhanced efficacy and a favorable safety profile.
Mia E, Rahman MA, Shipon MNH, Mou MA, Mandal P, Rakib IH, Sayeed MA, Islam MT, Al Hasan MS, Ansari MA.   +9 more
europepmc   +2 more sources

Neuroprotective and anticonvulsant effect of trimetazidine in a PTZ-kindling model of mice through modulation of the IL-1β/IL-1R1 and HMGB-1/TLR-4 axis. [PDF]

Front Pharmacol
Ahmad S, Samim M, Jain S, Vohora D, Nidhi.   +4 more
europepmc   +1 more source

Cannabidiol potentiates phenobarbital effects in the control of pentylenetetrazole (PTZ)-induced epileptic seizures in neonate rats. [PDF]

Front Pediatr
Pinto LS, de Oliveira MS, Borges GB, de Castro OW, Moreira FA, Santos VR.   +5 more
europepmc   +1 more source

Potential effect of endothelial progenitor cells on pentylenetetrazole-induced seizures in rats: an evaluation of relevant lncRNAs. [PDF]

J Zhejiang Univ Sci B
Ali SO, Shahin NN, Safar MM, Rizk SM.
europepmc   +1 more source

Antiepileptic and antiepileptogenic effects of <i>Lagenaria siceraria</i> aqueous extract (Curcubitaceae) in PTZ-induced kindling in rats. [PDF]

IBRO Neurosci Rep
Gnoupa KK, Ngoupaye GT, Foutsop AF, Kom BTD, Ngoufack SBK, Noubouwo CJ, Diane RB.   +6 more
europepmc   +1 more source

TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies. [PDF]

Front Mol Neurosci
Deng G, Liu D, Zhong Y, Wang M, Su B, Jiang H, Zhai Y, Peng H, Zhang C, Feng J.   +9 more
europepmc   +1 more source

Adropin ameliorates behavioral seizures and the relevant neuroinflammation, oxidative stress, and neural damage in a rat model of pentylenetetrazole-induced seizure potentially by reducing the activation of NF-κB/IkB-α signaling pathway. [PDF]

Metab Brain Dis
Namulodi S, Torun IE, Bayiroglu F, Kaya MS, Kilinc E.   +4 more
europepmc   +1 more source

<i>Panax notoginseng</i> Flower Extract Attenuates Pentylenetetrazole-Induced Epilepsy by Restoring Glutamate Homeostasis. [PDF]

Brain Sci
Zhao Y, Zhu F, Xie J, Wang Y, Matsabisa M, Tang M.   +5 more
europepmc   +1 more source

Vitamin E-valproate co-therapy attenuated oxidative stress, neuroinflammation, related cognitive deficits and neuronal damage in Cypermethrin exacerbated seizure. [PDF]

BMC Pharmacol Toxicol
Imam A, Tunde AM, Amin A, Abdulmajeed WI, Attai AG, Akorede AA, Ijomone OM, Ajao MS.   +7 more
europepmc   +1 more source