Results 1 to 10 of about 4,421 (183)

Chronic sleep deprivation promotes drug-resistant epilepsy via the BMAL1-mTOR-P-gp axis. [PDF]

Epilepsia Open
Abstract Objective The interplay between chronic sleep deprivation and drug‐resistant epilepsy (DRE) has gained increasing attention. Brain and muscle Arnt‐like protein 1 (BMAL1), which is implicated in sleep disturbance, has an unclear role in DRE. We aimed to investigate the role of BMAL1 in sleep deprivation‐induced DRE. Methods A pentylenetetrazole
Wang X, Li R, Zhang Y, Hu Y, Chen J, Tian S, Zhou D, Chi X.   +7 more
europepmc   +2 more sources

Virtual Screening and Zebrafish Phenotype-Based Evaluation Argues Against Repurposing 4-Phenylbutyrate for STXBP1-Related Disorders. [PDF]

Pharmacol Res Perspect
ABSTRACT Syntaxin‐binding protein 1 (STXBP1) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18‐1 (STXBP1) C. elegans models demonstrate that 4‐phenylbutyrate (4‐PBA) or related pharmacological chaperones stabilize ...
Frick A, Whyte-Fagundes P, Baraban SC.
europepmc   +2 more sources

Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABA_A Receptor and Voltage-Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies. [PDF]

Brain Behav
Citronellal, daidzin, and phytol exert significant anticonvulsant effects in a chick seizure model by enhancing GABAergic transmission and blocking voltage‐gated sodium channels, with combination therapies showing enhanced efficacy and a favorable safety profile.
Mia E, Rahman MA, Shipon MNH, Mou MA, Mandal P, Rakib IH, Sayeed MA, Islam MT, Al Hasan MS, Ansari MA.   +9 more
europepmc   +2 more sources

Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

Frontiers in Pharmacology
Clinical studies have shown that epileptic seizures worsen Alzheimer’s disease (AD) pathology and related cognitive deficits; however, the underlying mechanism is unclear.
Zhou Chen, Gan Chen-Ling, Chen-Ling Gan   +2 more
exaly   +3 more sources

Preparation and Evaluation of Carbamazepine Solid Lipid Nanoparticle for Alleviating Seizure Activity in Pentylenetetrazole-Kindled Mice

Molecules, 2019
Objectives: The study aimed to prepare carbamazepine in solid lipid nanoparticle form (CBZ-SLN) in order to enhance its anticonvulsant effect. Method: Eight formulations of CBZ-SLNs were prepared by homogenization and ultra-sonication techniques. Results:
Mohammad M Abd-Alhaseeb Elmahdy, Kousalya Prabahar, Mona Qushawy   +2 more
exaly   +3 more sources

Effect of Deep Brain Stimulation in The Ventral Tegmental Area on Neuronal Activity in Local and Remote Brain Regions in Kindled Mice [PDF]

Cell Journal, 2023
Objective: The mechanisms behind seizure suppression by deep brain stimulation (DBS) are not fully revealed, andthe most optimal stimulus regimens and anatomical targets are yet to be determined. We investigated the modulatoryeffect of low-frequency DBS (
Parisa Esmaeili Tazangi, Faisal Alosaimi, Fatemeh Bakhtiarzadeh, Amir Shojaei, Ali Jahanshahi, Javad Mirnajafi-Zadeh   +5 more
doaj   +1 more source

EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line

Frontiers in Cellular Neuroscience, 2023
BackgroundTransient receptor potential (TRP) channels have been found to have significant implications in neuronal outgrowth, survival, inflammatory neurogenic pain, and various epileptogenic processes.
Ishak Suat Ovey, Ahmet Ozsimsek, Halil Aziz Velioglu, Halil Aziz Velioglu, Ozlem Altay, Adil Mardinoglu, Burak Yulug, Burak Yulug   +7 more
doaj   +1 more source

Effects of Hydro-ethanolic Extract of Tanacetum parthenium and its N-Butanol and Aqueous Fractions on Brain Oxidative Damage in Pentylenetetrazole-Induced Seizures in Mice [PDF]

Pharmaceutical Sciences, 2020
Background: Epileptic seizures affect the life of noticeable number of people in all over the world. Tanacetum parthenium (TP) is used in traditional medicine.
Fereshteh Asgharzadeh, Mahmoud Hosseini, Rahimeh Bargi, Farimah Beheshti, Hassan Rakhshandeh, Somaieh Mansouri, Azita Aghaei, Hamid Reza Sadeghnia, Akbar Anaeigoudari   +8 more
doaj   +1 more source

Effect of Artemisia persica on seizure severity and memory and learning disorders in pentylenetetrazole-kindled mice

Bangladesh Journal of Pharmacology, 2019
The purpose of this study was to investigate the effect of hydroalcoholic extract of Artemisia persica (100, 200 and 400 mg/kg) on pentylenetetrazole-induced seizure and memory impairment. Sixty mice were assigned to seven groups.
Mozhgan Daneshkhah, Mahbubeh Setorki
doaj   +3 more sources

Acute and Sub-chronic Anticonvulsant Effects of Edaravone on Seizure Induced by Pentylenetetrazole or Electroshock in Mice, Nitric Oxide Involvement [PDF]

Iranian Journal of Medical Sciences, 2023
Background: Edaravone is an anti-stroke medication that may have nitric oxide (NO) modulating properties. This study evaluated the role of NO in the acute and sub-chronic anticonvulsant effects of edaravone in murine models of seizures induced by ...
Leila Moezi, Fatema Pirsalami, Mona Dastgheib, Somayeh Oftadehgan, Azar Purkhosrow, Elahe Sattarinezhad   +5 more
doaj   +1 more source