Results 41 to 50 of about 6,209 (222)

Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration

, 1989
Isatin has recently been identified in rat tissues and normal human urine where it constitutes the major part of the endogenous monoamine oxidase inhibitor, tribulin.
Davidson, J., Watkins, P.J., Glover, V., Sandler, M., Clow, A., Halket, J., Milton, A.S.   +6 more
core   +1 more source

Effects of thymus vulgaris l. in acute and chronic epilepsy models in rats induced by pentylenetetrazole [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
The aim of this study was to investigate the effects of Thymus vulgaris L. (TVL) on oxidative stress, motor coordination and learning/memory in acute and chronic epilepsy models in rats induced by Pentylenetetrazole (PTZ).
Hülya ÖZDEMİR, Vedat SAĞMANLIGİL, Özlem Ergül ERKEÇ, Gökhan OTO, Yıldıray BAŞBUĞAN, Hasan UYAR   +5 more
doaj   +1 more source

Gender differences in a Drosophila transcriptomic model of chronic pentylenetetrazole induced behavioral deficit

, 2009
A male Drosophila model of locomotor deficit induced by chronic pentylenetetrazole (PTZ), a proconvulsant used to model epileptogenesis in rodents, has recently been described.
Abhay Sharma, Farhan Mohammad, Sharma Abhay, Mohammad Farhan, Singh P., Singh Priyanka, Mohammad F., Sharma A., Priyanka Singh   +8 more
core   +1 more source

Mast cell activation ameliorates pentylenetetrazole‐induced seizures in rats: The potential role for serotonin

, 2021
Neuroinflammation plays a key role in the pathogenesis of epilepsy, but the underlying mechanisms are not well understood. Mast cells are multifunctional immune cells that are also activated by stress.
Erkan Kilinc, Ibrahim Ethem Torun, Fatma Tore, Ayhan Cetinkaya, Çetinkaya, Ayhan, Töre, Fatma, Kılınç, Erkan, Torun, İbrahim Ethem   +7 more
core   +1 more source

Zizyphus spina christi Effect on Pentylenetetrazole-Induced Kindling

The Iraqi Journal of Medical Sciences, 2021
Background: Epilepsy is a common disorder of brain that is not well controlled via drugs available for it. Gephyrin, a well-known inhibitory synaptic regulator, has a role in epilepsy.
Abeer Al-Humaidhi, Abdulkareem Abd, Haider Ghazi   +2 more
doaj   +1 more source

Baicalein administration protects against pentylenetetrazole-induced chronic epilepsy in rats

, 2018
Purpose: To investigate the protective effect of baicalein against chronic seizures in pentylenetetrazole induced epilepsy in a rat model.Methods: A rat model of chronic epilepsy was prepared by administration of pentylenetetrazole at a dose of 35 mg/kg ...
Wang, Xiuping, Zhang, Junwu, Li, Peiyu
core   +1 more source

Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

Frontiers in Pharmacology
Clinical studies have shown that epileptic seizures worsen Alzheimer’s disease (AD) pathology and related cognitive deficits; however, the underlying mechanism is unclear.
Yulian Zou, Chengyan Wang, Huang Li, Meihua Zhong, Jin Lin, Yan Hu, Zhou Chen, Chen-Ling Gan   +7 more
doaj   +1 more source

Interactions of caffeine and nitric oxide on pentylenetetrazole-induced clonic and tonic seizures in mice [PDF]

Basic and Clinical Biochemistry and Nutrition
Background: Caffeine, a non-selective antagonist of adenosine receptors (ARs), may affect the anticonvulsant properties of adenosine through modulation of the nitric oxide (NO) pathway.Objectives: This study aimed to investigate the impact of caffeine ...
Hassan Jamali, Azhdar Heydari
doaj   +1 more source

Anxiolytic Effect of the Hydro-alcoholic Extract of Anethum Graveolens Seed in Adult Female Wistar Rats: Modulation of GABA Receptors

Caspian Journal of Neurological Sciences, 2022
Background: Along with industrial development and the increasing social complexity of societies, anxiety is one of the most prevalent psychological disorders. Medicinal plants are considered as an enrichment source of ingredients with biological activity.
Farshid Saadat, Behrooz Khakpour, Rana Shahabi, Mohammad Rostampour, Bahram Soltani   +4 more
doaj   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source