Results 41 to 50 of about 9,677 (229)

Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

Frontiers in Pharmacology
Clinical studies have shown that epileptic seizures worsen Alzheimer’s disease (AD) pathology and related cognitive deficits; however, the underlying mechanism is unclear.
Yulian Zou, Chengyan Wang, Huang Li, Meihua Zhong, Jin Lin, Yan Hu, Zhou Chen, Chen-Ling Gan   +7 more
doaj   +1 more source

Interactions of caffeine and nitric oxide on pentylenetetrazole-induced clonic and tonic seizures in mice [PDF]

Basic and Clinical Biochemistry and Nutrition
Background: Caffeine, a non-selective antagonist of adenosine receptors (ARs), may affect the anticonvulsant properties of adenosine through modulation of the nitric oxide (NO) pathway.Objectives: This study aimed to investigate the impact of caffeine ...
Hassan Jamali, Azhdar Heydari
doaj   +1 more source

Anxiolytic Effect of the Hydro-alcoholic Extract of Anethum Graveolens Seed in Adult Female Wistar Rats: Modulation of GABA Receptors

Caspian Journal of Neurological Sciences, 2022
Background: Along with industrial development and the increasing social complexity of societies, anxiety is one of the most prevalent psychological disorders. Medicinal plants are considered as an enrichment source of ingredients with biological activity.
Farshid Saadat, Behrooz Khakpour, Rana Shahabi, Mohammad Rostampour, Bahram Soltani   +4 more
doaj   +1 more source

Sodium‐glucose cotransporter 2 inhibitors and the risk of late onset epilepsy: A real‐world cohort study

Epilepsia, EarlyView.
Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin, Hui‐Min Huang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures [PDF]

, 2012
The availability of animal models of epileptic seizures provides opportunities to identify novel anticonvulsants for the treatment of people with epilepsy.
Anandahan, Baraban, Baraban, Baraban, Berghmans, Bozzi, Buchholtz, Cachat, Cachat, Chang, Colman, Coyne, Cramer, Darland, Dhir, Feldman, Greenberg, Greer, Heilig, Hortopan, Hortopan, Hosie, Huang, Kaminski, Kokel, Lin, Lipsky, Loebrich, Luszczki, Löscher, Mahé, Mishra, Nalivaeva, Norton, Pack, Picazo, Reddy, Reddy, Reid, Remy, Sarang, Seeman, Stafstrom, Steenbergen, Stewart, Thisse, Thorsell, Tian, Tochman, Tutka, Vale, Von Hofsten, Wallenstein, Winter, Zhang   +54 more
core   +2 more sources

Protective Effects of Wheat Germ Oil on the IVF, Oxidative Stress and In Vitro Zygote Development in Carbamazepine Treated Epileptic Male Mice

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020
Background and Objectives: Epilepsy is a neurological disorder caused by abnormal electrical discharges from the brain. Carbamazepine is used to treat epilepsy. Over time, this drug may increase oxidative stress and reproductive abnormalities in patients
Ghodrat Ebadi Manas, Gholamreza Najafi
doaj  

Synthesis and Evaluation of the Anticonvulsant Activities of 4-(2-(Alkylthio)benzo[d]oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-ones

Molecules, 2018
In this study, a novel series of 4-(2-(alkylthio)benzo[d]oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-ones (4a–m) was designed and synthesized. The anticonvulsant activities of these compounds were evaluated by using the maximal electroshock seizure (MES)
Ming-Xia Song, Zhen-Yuan Wang, Shi-Hui He, Sheng-Wang Yu, Shi-Long Chen, Dong-Fu Guo, Wen-Hao Zhao, Xian-Qing Deng   +7 more
doaj   +1 more source

Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model

Pharmaceuticals, 2021
The disturbed metabolism of vitamins B1 or B6, which are essential for neurotransmitters homeostasis, may cause seizures. Our study aims at revealing therapeutic potential of vitamins B1 and B6 by estimating the short- and long-term effects of their ...
Vasily A. Aleshin, Anastasia V. Graf, Artem V. Artiukhov, Alexandra I. Boyko, Alexander L. Ksenofontov, Maria V. Maslova, Isabel Nogués, Martino L. di Salvo, Victoria I. Bunik   +8 more
doaj   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source