Results 41 to 50 of about 7,019 (224)

Kv3.1 activation suppresses provoked and spontaneous seizures in a mouse Dravet syndrome model

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acidergic (GABAergic) parvalbumin‐positive (PV+) interneurons are critical for maintaining cortical inhibitory tone, with their dysfunction predictably leading to epilepsy. Rapid PV+ interneuron firing is essential for their normal function and is maintained in part by potassium voltage‐gated channels.
Sheryl Anne D. Vermudez, Mustafa Q. Hameed, Yongho Choe, Gabrielle E. McGinty, Amanda M. Liebhardt, Rui Lin, Benjamin Hui, Yini Liang, David J. Arce, Henry H. C. Lee, Mustafa Sahin, Alexander Rotenberg   +11 more
wiley   +1 more source

Ethosuximide affects both pentylenetetrazole- and kainate-induced clonic seizures but differentiates between tonic–clonic seizures

, 1989
Young (25-day-old) and adult (90-day-old) rats pretreated with ethosuximide (62.5 or 125 mg/kg i.p.) were injected with either s.c. pentylenetetrazole (100 mg/kg) or i.p. kainate (10 or 14 mg/kg). The incidences and latencies of minor (clonic) and major
Pavel Mareš, Jana Velíšková, Helena Mirvaldová, Libor Velíšek, Ivana Kulhánková, Lenka Roztočilová   +5 more
core   +1 more source

Zizyphus spina christi Effect on Pentylenetetrazole-Induced Kindling

The Iraqi Journal of Medical Sciences, 2021
Background: Epilepsy is a common disorder of brain that is not well controlled via drugs available for it. Gephyrin, a well-known inhibitory synaptic regulator, has a role in epilepsy.
Abeer Al-Humaidhi, Abdulkareem Abd, Haider Ghazi   +2 more
doaj   +1 more source

Do preclinical seizure models predict success or failure in anti‐seizure drug development? A retrospective analysis of 89 compounds with divergent clinical outcomes for epilepsy

Epilepsia, EarlyView.
Abstract Anti‐seizure medication (ASM) discovery remains a major challenge despite over 30 commercially available options. One persistent obstacle for any promising candidate compound to successfully move from preclinical study to clinical approval has been the ambiguity in preclinical model selection.
Wolfgang Löscher, Melissa Barker‐Haliski   +1 more
wiley   +1 more source

Protective Effects of Wheat Germ Oil on the IVF, Oxidative Stress and In Vitro Zygote Development in Carbamazepine Treated Epileptic Male Mice

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020
Background and Objectives: Epilepsy is a neurological disorder caused by abnormal electrical discharges from the brain. Carbamazepine is used to treat epilepsy. Over time, this drug may increase oxidative stress and reproductive abnormalities in patients
Ghodrat Ebadi Manas, Gholamreza Najafi
doaj  

Interactions of caffeine and nitric oxide on pentylenetetrazole-induced clonic and tonic seizures in mice [PDF]

Basic and Clinical Biochemistry and Nutrition
Background: Caffeine, a non-selective antagonist of adenosine receptors (ARs), may affect the anticonvulsant properties of adenosine through modulation of the nitric oxide (NO) pathway.Objectives: This study aimed to investigate the impact of caffeine ...
Hassan Jamali, Azhdar Heydari
doaj   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

_Drosophila_ and human transcriptomic data mining provides evidence for therapeutic mechanism of pentylenetetrazole in Down syndrome [PDF]

, 2010
Pentylenetetrazole (PTZ) has recently been found to ameliorate cognitive impairment in rodent models of Down syndrome (DS). The mechanism underlying PTZ’s therapeutic effect is however not clear.
Abhay Sharma
core  

The ionic mechanism of the pentylenetetrazol convulsions. [PDF]

Acta biologica Hungarica, 1987
The ionic dependence and the nature of conductance was examined at slowly inactivating inward current in metacerebral giant cells of Helix pomatia, induced by 50 mM pentylenetetrazol. Ramp and square wave depolarizations in voltage clamp mode revealed, that withdrawal of sodium ions prevented this current to flow.
Papp András, Fehér Ottó, Erdelyi L.
openaire   +1 more source

The basal ganglia and the epilepsies

Epilepsia Open, EarlyView.
Abstract The basal ganglia are an evolutionarily conserved neural circuit best known for the selection and sequencing of voluntary movement. Increasing evidence, however, indicates that these structures also play an important role in regulating pathological brain states, including seizures.
Willian Lazarini‐Lopes, Logan Perry, Patrick A. Forcelli   +2 more
wiley   +1 more source