Results 51 to 60 of about 9,677 (229)

The ionic mechanism of the pentylenetetrazol convulsions. [PDF]

Acta biologica Hungarica, 1987
The ionic dependence and the nature of conductance was examined at slowly inactivating inward current in metacerebral giant cells of Helix pomatia, induced by 50 mM pentylenetetrazol. Ramp and square wave depolarizations in voltage clamp mode revealed, that withdrawal of sodium ions prevented this current to flow.
Papp András, Fehér Ottó, Erdelyi L.
openaire   +1 more source

Anticonvulsant and related neuropharmacological effects of the whole plant extract of Synedrella nodiflora (L.) Gaertn (Asteraceae)

Journal of Pharmacy and Bioallied Sciences, 2012
Purpose: The plant Synedrella nodiflora (L) Gaertn is traditionally used by some Ghanaian communities to treat epilepsy. To determine if this use has merit, we studied the anticonvulsant and other neuropharmacological effects of a hydro-ethanolic extract
Patrick Amoateng, Eric Woode, Samuel B Kombian   +2 more
doaj   +1 more source

Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice

Molecules, 2021
Ellagic acid (EA) is a natural dietary polyphenol that has many beneficial properties, including anti-inflammatory, antioxidant, antiviral, antibacterial, and neuroprotective effects.
Mateusz Pieróg, Katarzyna Socała, Elżbieta Wyska, Ewa Poleszak, Piotr Wlaź   +4 more
doaj   +1 more source

Chronic sleep deprivation promotes drug‐resistant epilepsy via the BMAL1‐mTOR‐P‐gp axis

Epilepsia Open, EarlyView.
Abstract Objective The interplay between chronic sleep deprivation and drug‐resistant epilepsy (DRE) has gained increasing attention. Brain and muscle Arnt‐like protein 1 (BMAL1), which is implicated in sleep disturbance, has an unclear role in DRE. We aimed to investigate the role of BMAL1 in sleep deprivation‐induced DRE. Methods A pentylenetetrazole
Xiaomeng Wang, Rui Li, Yuzhu Zhang, Yi Hu, Jingjiao Chen, Sijia Tian, Dong Zhou, Xiaosa Chi   +7 more
wiley   +1 more source

Peripheral Infection after Traumatic Brain Injury Augments Excitability in the Perilesional Cortex and Dentate Gyrus

Biomedicines, 2021
Peripheral infections occur in up to 28% of patients with traumatic brain injury (TBI), which is a major etiology for structural epilepsies. We hypothesized that infection occurring after TBI acts as a “second hit” and facilitates post-traumatic ...
Ying Wang, Pedro Andrade, Asla Pitkänen
doaj   +1 more source

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, Volume 6, Issue 5, May 2026.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source

Pioglitazone Ameliorates Hippocampal Neurodegeneration, Disturbances in Glucose Metabolism and AKT/mTOR Signaling Pathways in Pentyelenetetrazole-Kindled Mice

Pharmaceuticals, 2022
Disturbance of glucose metabolism, nerve growth factor (NGF) and m-TOR signaling have been associated with the pathophysiology of epilepsy. Pioglitazone (PGZ) is an anti-diabetic drug that shows a protective effect in neurodegenerative diseases including
Nada El-Megiri, Yasser M. Mostafa, Amal Ahmed, Eman T. Mehanna, Mona F. El-Azab, Fatma Alshehri, Hadil Alahdal, Norhan M. El-Sayed   +7 more
doaj   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation [PDF]

, 2016
Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the ...
A Berenyi, A Ilhan, AP Yadav, CA Schevon, CM DeGiorgio, CN Shealy, D Gervasoni, DJ Mogul, EE Fanselow, EE Fanselow, EE Fanselow, G Fenelon, GK Bergey, H Kahlow, J Christensen, J Jiao, JR Schlaier, JT Paz, K Dzirasa, K Dzirasa, KR Harreby, L Morgante, M Davoudi, M Pais-Vieira, M Pais-Vieira, M Zare, MA Nicolelis, MB Santana, MC Picot, MG Corda, MJ Morrell, OE Erkec, R Fisher, R Fuentes, SM Hayek, T Agari, T Zhang, V De Herdt, V Salanova, VB-surgery Horsley, W Loscher   +40 more
core   +3 more sources

Pentylenetetrazole Kindling Affects Sleep in Rats [PDF]

Epilepsia, 2006
Summary:  Purpose: The aim of the study was to define sleep disturbances in pentylenetetrazole (PTZ)‐kindled rats and to explore the effects of the nootropic drug piracetam (Pir; 100 mg/kg) and the noncompetitive N‐methyl‐d‐aspartate (NMDA)‐antagonist MK‐801 (0.3 mg/kg), which normalized learning performance in PTZ‐kindled rats, on altered sleep ...
Markus, Schilling, Wolfram, Wetzel, Gisela, Grecksch, Axel, Becker   +3 more
openaire   +2 more sources