Results 31 to 40 of about 7,019 (224)

Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain

, 1991
The effects of i.p. injection of 3 aromatic amino acids and two anxiogenic agents on rat brain isatin concentration and tribulin (endogenous monoamine oxidase inhibitor) activity were investigated.
Bhattacharya, S.K., Glover, V., Sandler, M., Clow, A., Przyborowska, A., Halket, J.   +5 more
core   +1 more source

Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration

, 1989
Isatin has recently been identified in rat tissues and normal human urine where it constitutes the major part of the endogenous monoamine oxidase inhibitor, tribulin.
Davidson, J., Watkins, P.J., Glover, V., Sandler, M., Clow, A., Halket, J., Milton, A.S.   +6 more
core   +1 more source

Baicalein administration protects against pentylenetetrazole-induced chronic epilepsy in rats [PDF]

, 2018
Purpose: To investigate the protective effect of baicalein against chronic seizures in pentylenetetrazole induced epilepsy in a rat model.Methods: A rat model of chronic epilepsy was prepared by administration of pentylenetetrazole at a dose of 35 mg/kg ...
Wang, Xiuping, Zhang, Junwu, Li, Peiyu
core   +1 more source

Anticonvulsive and Antioxidant Effects of Pioglitazone on Pentylenetetrazole-Induced Seizures in Rats

The Journal of Qazvin University of Medical Sciences, 2020
Background Epilepsy is a neurologic dysfunction caused by abnormal electrical activity in the brain. Oxidative stress is involved in the seizure-induced brain damage.
Yasaman Ghiasi, Saba Rostamian, Ehsan Aali, Yazdan Naderi   +3 more
doaj   +1 more source

Effects of intravenous administration of propofol and midazolam on pentylenetetrazole kindled seizures in rats

Arab Journal of Basic and Applied Sciences, 2021
To date, studies examining the proconvulsants or anticonvulsants in chronic epileptic models in rat are rare. Propofol has conflicting reports regarding the pro- or anti-convulsant effects on chronic seizures.
Zuheir A. Hasan, Rima L. Abdul Razzak, Karem H. Alzoubi, Ammar M. Marwani   +3 more
doaj   +1 more source

Mast cell activation ameliorates pentylenetetrazole‐induced seizures in rats: The potential role for serotonin

, 2021
Neuroinflammation plays a key role in the pathogenesis of epilepsy, but the underlying mechanisms are not well understood. Mast cells are multifunctional immune cells that are also activated by stress.
Erkan Kilinc, Ibrahim Ethem Torun, Fatma Tore, Ayhan Cetinkaya, Çetinkaya, Ayhan, Töre, Fatma, Kılınç, Erkan, Torun, İbrahim Ethem, Kilinc, ERKAN   +8 more
core   +1 more source

Effects of compounds acting on GABA(B) receptors in the pentylenetetrazole kindling model of epilepsy in mice

, 2000
The involvement of GABA(B) receptors in the behavioural and epileptic electrocortical discharges occurring in chemical kindling induced by repeated treatments with a subconvulsant dose of pentylenetetrazole (25 mg/kg i.p.) has been investigated in CD1 ...
Costa N, De Sarro G, Palma E, Gratteri S, Rotiroti D, De Sarro A, Marra R   +6 more
core   +1 more source

Impact of Human Chorionic Gonadotropin on Pentylenetetrazol-Induced Seizure Activities in Mice: Modulation of miR-181a Expression as a Potential Neuroprotective Mechanism [PDF]

Journal of Shahrekord University of Medical Sciences
Introduction: Epilepsy affects millions of people globally, with 30% of patients exhibiting drug resistance, necessitating novel therapies. Human chorionic gonadotropin (hCG), known for neuroprotective effects, has been underexplored in epilepsy despite ...
Gholamreza Mobini, Zahra Rabiei, Hamid Shahmoradi, Anahita Farahzad   +3 more
doaj   +1 more source

Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

Frontiers in Pharmacology
Clinical studies have shown that epileptic seizures worsen Alzheimer’s disease (AD) pathology and related cognitive deficits; however, the underlying mechanism is unclear.
Yulian Zou, Chengyan Wang, Huang Li, Meihua Zhong, Jin Lin, Yan Hu, Zhou Chen, Chen-Ling Gan   +7 more
doaj   +1 more source

Effects of thymus vulgaris l. in acute and chronic epilepsy models in rats induced by pentylenetetrazole [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
The aim of this study was to investigate the effects of Thymus vulgaris L. (TVL) on oxidative stress, motor coordination and learning/memory in acute and chronic epilepsy models in rats induced by Pentylenetetrazole (PTZ).
Hülya ÖZDEMİR, Vedat SAĞMANLIGİL, Özlem Ergül ERKEÇ, Gökhan OTO, Yıldıray BAŞBUĞAN, Hasan UYAR   +5 more
doaj   +1 more source