Results 31 to 40 of about 9,677 (229)
Molecules, 2016 New benztriazoles with a mercapto-triazole and other heterocycle substituents were synthesized and evaluated for their anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ), and rotarod
Da-Chuan Liu +3 more
doaj +1 more source
The Effect of Low-Doses of Caffeine and Taurine on Convulsive Seizure Parameters in Rats
Behavioral Sciences, 2020 Introduction: Caffeine, an adenosine-receptor blocker, is believed to have neuronal excitatory effects, while Taurine, a mammalian amino acid, was shown to have neuroinhibitory effects.
Mohamed Jailani +9 more
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Neuroprotective role of acamprosate and rasagiline in epilepsy: In silico and in vivo study [PDF]
Scripta MedicaBackground/Aim: Current treatments for epilepsy have only indicative relief without smashing the pathological trademarks of the disease. The unmet need is to find new therapeutic active drug candidates for effective management of epilepsy and associated ...
Kumar Sandeep +7 more
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The Journal of Qazvin University of Medical Sciences, 2020 Background Epilepsy is a neurologic dysfunction caused by abnormal electrical activity in the brain. Oxidative stress is involved in the seizure-induced brain damage.
Yasaman Ghiasi +3 more
doaj +1 more source
Arab Journal of Basic and Applied Sciences, 2021 To date, studies examining the proconvulsants or anticonvulsants in chronic epileptic models in rat are rare. Propofol has conflicting reports regarding the pro- or anti-convulsant effects on chronic seizures.
Zuheir A. Hasan +3 more
doaj +1 more source
Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression [PDF]
, 2013 To date, anticonvulsant effects of the plant cannabinoid, cannabidivarin (CBDV), have been reported in several animal models of seizure. However, these behaviourally observed anticonvulsant effects have not been confirmed at the molecular level.
Beckmann +53 more
core +2 more sources
Effects of thymus vulgaris l. in acute and chronic epilepsy models in rats induced by pentylenetetrazole [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019 The aim of this study was to investigate the effects of Thymus vulgaris L. (TVL) on oxidative stress, motor coordination and learning/memory in acute and chronic epilepsy models in rats induced by Pentylenetetrazole (PTZ).
Hülya ÖZDEMİR +5 more
doaj +1 more source
Optical mapping of neuronal activity during seizures in zebrafish [PDF]
, 2017 Mapping neuronal activity during the onset and propagation of epileptic seizures can provide a better understanding of the mechanisms underlying this pathology and improve our approaches to the development of new drugs.
Fornetto, C +10 more
core +3 more sources
Zizyphus spina christi Effect on Pentylenetetrazole-Induced Kindling
The Iraqi Journal of Medical Sciences, 2021 Background: Epilepsy is a common disorder of brain that is not well controlled via drugs available for it. Gephyrin, a well-known inhibitory synaptic regulator, has a role in epilepsy.
Abeer Al-Humaidhi +2 more
doaj +1 more source
Cyclopentenyl ethylamines active on CNS [PDF]
, 1992 Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic
Dimich, P.M. +6 more
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