Results 31 to 40 of about 6,209 (222)

Olig2-specific loss-of-function Slc35a2 results in hypomyelination and spontaneous seizures. [PDF]

Epilepsia
Abstract Objective Malformations of cortical development represent major causes of drug‐resistant epilepsy, with mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy recognized as a distinct pathological entity. Pathogenic X‐linked SLC35A2, encoding the uridine diphosphate–galactose transporter, has been implicated ...
Bartel TM, Ghosh C, Bisaha K, Khoury J, Nemes-Baran A, Blumcke I, Najm I.   +6 more
europepmc   +2 more sources

Effect of Hydroalcoholic Extract of Stachys lavandulifolia on Pentylenetetrazole-induced Seizures in Male Mice: The Role of GABAergic and Opioidergic Systems

Basic and Clinical Neuroscience, 2022
Introduction: Epilepsy is one of the most common neurological disorders. Though there are several effective drugs for treating epilepsy, most drugs are associated with side effects and drug interactions. Stachys lavandulifolia used in Iranian traditional
Hamid Behzadnia, Amin Naseri, Mohammadreza Emamhadi, Shervin Ghadarjani, Iraj Aghaei, Ahmadreza Dehpour   +5 more
doaj  

Anticonvulsant and Neuroprotective Activities ofPhragmanthera austroarabicaExtract in Pentylenetetrazole-Kindled Mice [PDF]

, 2017
Anticonvulsant and neuroprotective activity ofPhragmanthera austroarabicaextract were tested in pentylenetetrazole-kindled mice. All the chemical constituents of the plant extract were identified.
Basma G. Eid, Jihan M. Badr, Hibah M. Aldawsari, Thikrayat Neamatallah, Sawsan A. Zaitone   +4 more
core   +1 more source

Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Potential Anticonvulsant Agents

Molecules, 2016
New benztriazoles with a mercapto-triazole and other heterocycle substituents were synthesized and evaluated for their anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ), and rotarod
Da-Chuan Liu, Hong-Jian Zhang, Chun-Mei Jin, Zhe-Shan Quan   +3 more
doaj   +1 more source

The Effect of Low-Doses of Caffeine and Taurine on Convulsive Seizure Parameters in Rats

Behavioral Sciences, 2020
Introduction: Caffeine, an adenosine-receptor blocker, is believed to have neuronal excitatory effects, while Taurine, a mammalian amino acid, was shown to have neuroinhibitory effects.
Mohamed Jailani, Mohamed Mubarak, Mariam Sarkhouh, Ahmed Al Mahrezi, Habib Abdulnabi, Mohamed Naiser, Husain Alaradi, Abdulaziz Alabbad, Maram Hassan, Amer Kamal   +9 more
doaj   +1 more source

Neuroprotective role of acamprosate and rasagiline in epilepsy: In silico and in vivo study [PDF]

Scripta Medica
Background/Aim: Current treatments for epilepsy have only indicative relief without smashing the pathological trademarks of the disease. The unmet need is to find new therapeutic active drug candidates for effective management of epilepsy and associated ...
Kumar Sandeep, Singh Govind, Chhikara Manisha, Shukla Sunil, Khatri Ramchander, Dar Mohammad Ovais, Lather Amit, Hooda Tanuj   +7 more
doaj   +1 more source

Anticonvulsive and Antioxidant Effects of Pioglitazone on Pentylenetetrazole-Induced Seizures in Rats

The Journal of Qazvin University of Medical Sciences, 2020
Background Epilepsy is a neurologic dysfunction caused by abnormal electrical activity in the brain. Oxidative stress is involved in the seizure-induced brain damage.
Yasaman Ghiasi, Saba Rostamian, Ehsan Aali, Yazdan Naderi   +3 more
doaj   +1 more source

Effects of intravenous administration of propofol and midazolam on pentylenetetrazole kindled seizures in rats

Arab Journal of Basic and Applied Sciences, 2021
To date, studies examining the proconvulsants or anticonvulsants in chronic epileptic models in rat are rare. Propofol has conflicting reports regarding the pro- or anti-convulsant effects on chronic seizures.
Zuheir A. Hasan, Rima L. Abdul Razzak, Karem H. Alzoubi, Ammar M. Marwani   +3 more
doaj   +1 more source

Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain

, 1991
The effects of i.p. injection of 3 aromatic amino acids and two anxiogenic agents on rat brain isatin concentration and tribulin (endogenous monoamine oxidase inhibitor) activity were investigated.
Bhattacharya, S.K., Glover, V., Sandler, M., Clow, A., Przyborowska, A., Halket, J.   +5 more
core   +1 more source

mRNA transcriptome from zebrafish pentylenetetrazole (PTZ) model

, 2021
Messenger RNA transcriptome data from wild-type zebrafish (Danio rerio) larvae after chemical-induced seizure using pentylenetetrazole (PTZ).. Three different conditions were investigated: (i) status epilepticus, SE (3h of PTZ-induced seizure); (ii ...
Vieira, André Schwambach, Maurer-Morelli, Cláudia Vianna, Nunes, Miriam Celi de Souza, Oliveira, Renato Aparecido de, Matos, Alexandre Hilário Berenguer de, Carvalho, Benílton de Sá, Rocha, Cristiane de Souza, Lopes-Cendes, Íscia Teresinha, Souza, Wélliton de, Zago, Vanessa Helena de Souza   +9 more
core   +1 more source