Results 21 to 30 of about 4,421 (183)
Pentylenetetrazol Kindling Epilepsy Model
Journal of the Turkish Epilepsi Society, 2015 Epilepsy is one of the most common neurologic disorders affecting approximately 1% of the general population, and no alleviation was achieved in one third of the patients medicated with antiepileptic drugs. Current treatments of epilepsy are symptomatic and have more anti-seizure effects than antiepileptic effects. These therapies do not cure epilepsy.
Arihan, Okan, Erkeç, Özlem Ergül
openaire +2 more sources
Basic and Clinical Neuroscience, 2022 Introduction: Epilepsy is one of the most common neurological disorders. Though there are several effective drugs for treating epilepsy, most drugs are associated with side effects and drug interactions. Stachys lavandulifolia used in Iranian traditional
Hamid Behzadnia +5 more
doaj
The Metabolic Fate of Pentylenetetrazol in the Rat
Canadian Journal of Physiology and Pharmacology, 1971 Pentylenetetrazol administered to rats was metabolized to a derivative which was excreted in the urine along with unchanged pentylenetetrazol. Pentylenetetrazol and its metabolite can be separated on paper chromatograms developed in water-saturated isobutanol. The substances, however, are chromatographically inseparable with water as the mobile phase.
G K, Ko, E A, Hosein
openaire +3 more sources
Molecules, 2016 New benztriazoles with a mercapto-triazole and other heterocycle substituents were synthesized and evaluated for their anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ), and rotarod
Da-Chuan Liu +3 more
doaj +1 more source
The Effect of Low-Doses of Caffeine and Taurine on Convulsive Seizure Parameters in Rats
Behavioral Sciences, 2020 Introduction: Caffeine, an adenosine-receptor blocker, is believed to have neuronal excitatory effects, while Taurine, a mammalian amino acid, was shown to have neuroinhibitory effects.
Mohamed Jailani +9 more
doaj +1 more source
Neuroprotective role of acamprosate and rasagiline in epilepsy: In silico and in vivo study [PDF]
Scripta MedicaBackground/Aim: Current treatments for epilepsy have only indicative relief without smashing the pathological trademarks of the disease. The unmet need is to find new therapeutic active drug candidates for effective management of epilepsy and associated ...
Kumar Sandeep +7 more
doaj +1 more source
The Journal of Qazvin University of Medical Sciences, 2020 Background Epilepsy is a neurologic dysfunction caused by abnormal electrical activity in the brain. Oxidative stress is involved in the seizure-induced brain damage.
Yasaman Ghiasi +3 more
doaj +1 more source
Arab Journal of Basic and Applied Sciences, 2021 To date, studies examining the proconvulsants or anticonvulsants in chronic epileptic models in rat are rare. Propofol has conflicting reports regarding the pro- or anti-convulsant effects on chronic seizures.
Zuheir A. Hasan +3 more
doaj +1 more source
Effects of thymus vulgaris l. in acute and chronic epilepsy models in rats induced by pentylenetetrazole [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019 The aim of this study was to investigate the effects of Thymus vulgaris L. (TVL) on oxidative stress, motor coordination and learning/memory in acute and chronic epilepsy models in rats induced by Pentylenetetrazole (PTZ).
Hülya ÖZDEMİR +5 more
doaj +1 more source
Zizyphus spina christi Effect on Pentylenetetrazole-Induced Kindling
The Iraqi Journal of Medical Sciences, 2021 Background: Epilepsy is a common disorder of brain that is not well controlled via drugs available for it. Gephyrin, a well-known inhibitory synaptic regulator, has a role in epilepsy.
Abeer Al-Humaidhi +2 more
doaj +1 more source