Effects of different anesthetic agents on GM-CSF, MCP1, IL1α and TNFα levels in rat sepsis model [PDF]
Acta Veterinaria, 2013 Anesthetic agents could alter the course and outcome of physical trauma, as well as experimentally or naturally occurring severe infections, by regulating several immune response mechanisms.
Vojvodić Danilo +7 more
doaj +1 more source
Brain Sciences, 2022 Approximately 30% of epileptic patients develop Drug-Resistant Epilepsy. Based on evidence that shows a loss of efficacy in some sodium channel blocker antiseizure drugs in epilepsy, we focus our study on assessing the anticonvulsant efficacy of ...
Cecilia Zavala-Tecuapetla +3 more
doaj +1 more source
Influence of NG-nitro-L-arginine methyl ester on clinical and biochemical effects of methylene blue in pentylenetetrazole-evoked convulsions [PDF]
Vojnosanitetski Pregled, 2012 Background/Aim. Despite years of research in a number of experimental models the question whether nitric oxide (NO) and methylene blue (MB) have pro- or anticonvulsant effects remains to be fully resolved. Methods.
Jelenković Ankica +4 more
doaj +1 more source
The Effect of Hydroalcoholic Extract of Salep on Pentylenetetrazole-Induced Seizure in Adult Male Rats [PDF]
Iranian Journal of Neurosurgery, 2023 Background and Aim: Epilepsy as a neurological disorder is characterized by unpredictable and periodic seizures. In the present study, the anticonvulsant effect of different doses of salep hydroalcoholic extract on pentylenetetrazole (PTZ) induced ...
Hossein Kargar Jahromi +7 more
doaj
Effects of L-carnitine and Ginkgo bilobaon cerebral cortex in experimentally-induced epileptic seizures disease in rat [PDF]
Journal of Bioscience and Applied Research, 2015 Pentylenetetrazole (PTZ) kindling is an acknowledged model for epilepsy and refers to a phenomenon in which repeated injection of this drug causes a gradual seizure. The current study aimed to determine the possible protective and ameliorative effects of
Ehab Tousson +2 more
doaj +1 more source
Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]
, 2014 Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core +1 more source
Cells, 2020 Palmatine (PALM) and berberine (BERB) are widely identified isoquinoline alkaloids among the representatives of the Berberidaceae botanical family. The antiseizure activity of BERB was shown previously in experimental epilepsy models.
Kinga Gawel +8 more
doaj +1 more source
The Anxiolytic and Antidepressant Effect of Tanacetum polycephalum in the Pentylenetetrazole Kindled Rats [PDF]
Research Journal of Pharmacognosy, 2020 Background and objective: Epilepsy one the most prevalent neurological illness which affects behavioral statuses like anxiety, depression and balance.
Vahid Azizi +3 more
doaj +1 more source
Anethole exerted anticonvulsant effect in pentylenetetrazolemodel of seizure in male mice: Possible antioxidant effects [PDF]
Future Natural Products, 2022 Background and aims: Epilepsy is a neurological disorder causing brain dysfunctions. Treatment and control of epilepsy have long been a challenge in medical sciences. Despite the variety of current anticonvulsant drugs, research continues to discover new
Sanaz Salimian +4 more
doaj +1 more source
The Metabolic Fate of Pentylenetetrazol in the Rat
Canadian Journal of Physiology and Pharmacology, 1971 Pentylenetetrazol administered to rats was metabolized to a derivative which was excreted in the urine along with unchanged pentylenetetrazol. Pentylenetetrazol and its metabolite can be separated on paper chromatograms developed in water-saturated isobutanol. The substances, however, are chromatographically inseparable with water as the mobile phase.
G K, Ko, E A, Hosein
openaire +3 more sources