Increased expression of matrix metalloproteinase-9 in patients with temporal lobe epilepsy [PDF]
, 2014 Aim: The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited.
Acar, Feridun +3 more
core +1 more source
Pentylenetetrazol Kindling Epilepsy Model
Journal of the Turkish Epilepsi Society, 2015 Epilepsy is one of the most common neurologic disorders affecting approximately 1% of the general population, and no alleviation was achieved in one third of the patients medicated with antiepileptic drugs. Current treatments of epilepsy are symptomatic and have more anti-seizure effects than antiepileptic effects. These therapies do not cure epilepsy.
Arihan, Okan, Erkeç, Özlem Ergül
openaire +2 more sources
Cells, 2020 Palmatine (PALM) and berberine (BERB) are widely identified isoquinoline alkaloids among the representatives of the Berberidaceae botanical family. The antiseizure activity of BERB was shown previously in experimental epilepsy models.
Kinga Gawel +8 more
doaj +1 more source
The Anxiolytic and Antidepressant Effect of Tanacetum polycephalum in the Pentylenetetrazole Kindled Rats [PDF]
Research Journal of Pharmacognosy, 2020 Background and objective: Epilepsy one the most prevalent neurological illness which affects behavioral statuses like anxiety, depression and balance.
Vahid Azizi +3 more
doaj +1 more source
Anethole exerted anticonvulsant effect in pentylenetetrazolemodel of seizure in male mice: Possible antioxidant effects [PDF]
Future Natural Products, 2022 Background and aims: Epilepsy is a neurological disorder causing brain dysfunctions. Treatment and control of epilepsy have long been a challenge in medical sciences. Despite the variety of current anticonvulsant drugs, research continues to discover new
Sanaz Salimian +4 more
doaj +1 more source
BETMB: A Dual-Target Compound for Synergistic Suppression of Neuronal Hyperexcitability in Refractory Epilepsy via Concurrent Modulation of Nav Channels and GABA<sub>A</sub> Receptors. [PDF]
CNS Neurosci TherBETMB exerts multi‐target effects by positively modulating GABAARs and blocking NaV channels in a state‐dependent manner. This suppresses neuronal hyperexcitability, leading to seizure control and restoration of cognitive function. ABSTRACT Aims This study aims to evaluate 5‐(but‐1‐en‐1‐yl)‐1,2,3‐trimethoxybenzene (BETMB) as a novel dual‐target anti ...
Zhang D +7 more
europepmc +2 more sources
The Metabolic Fate of Pentylenetetrazol in the Rat
Canadian Journal of Physiology and Pharmacology, 1971 Pentylenetetrazol administered to rats was metabolized to a derivative which was excreted in the urine along with unchanged pentylenetetrazol. Pentylenetetrazol and its metabolite can be separated on paper chromatograms developed in water-saturated isobutanol. The substances, however, are chromatographically inseparable with water as the mobile phase.
G K, Ko, E A, Hosein
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Basic and Clinical Neuroscience, 2022 Introduction: Epilepsy is one of the most common neurological disorders. Though there are several effective drugs for treating epilepsy, most drugs are associated with side effects and drug interactions. Stachys lavandulifolia used in Iranian traditional
Hamid Behzadnia +5 more
doaj
The Effects of Pregabalin on Cerebral Cortical Oxidative Stress of Rats on Pentylenetetrazole Induced Epileptic Seizure [PDF]
, 2013 Objectives: In this experimental model of epileptic seizure induced by pentylenetetrazole (PTZ), we aimed to investigate the effect of pregabalin, (PGB), (Lyrica(R)) in the brain cortex tissues and on superoxide dismutase (SOD) and catalase (CAT ...
Ahmet TÜFEKÇİ +4 more
core +1 more source
Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model. [PDF]
, 2020 Dravet syndrome is a catastrophic epilepsy of childhood, characterized by cognitive impairment, severe seizures, and increased risk for sudden unexplained death in epilepsy (SUDEP).
Anvar, Mana +3 more
core +1 more source