Results 21 to 30 of about 7,019 (224)

The Influence of Palmatine Isolated from Berberis sibirica Radix on Pentylenetetrazole-Induced Seizures in Zebrafish

open access: yesCells, 2020
Palmatine (PALM) and berberine (BERB) are widely identified isoquinoline alkaloids among the representatives of the Berberidaceae botanical family. The antiseizure activity of BERB was shown previously in experimental epilepsy models.
Kinga Gawel   +8 more
doaj   +1 more source

Anticonvulsant and Neuroprotective Activities ofPhragmanthera austroarabicaExtract in Pentylenetetrazole-Kindled Mice [PDF]

open access: yes, 2017
Anticonvulsant and neuroprotective activity ofPhragmanthera austroarabicaextract were tested in pentylenetetrazole-kindled mice. All the chemical constituents of the plant extract were identified.
Basma G. Eid   +4 more
core   +1 more source

The Anxiolytic and Antidepressant Effect of Tanacetum polycephalum in the Pentylenetetrazole Kindled Rats [PDF]

open access: yesResearch Journal of Pharmacognosy, 2020
Background and objective: Epilepsy one the most prevalent neurological illness which affects behavioral statuses like anxiety, depression and balance.
Vahid Azizi   +3 more
doaj   +1 more source

Effect of Hydroalcoholic Extract of Stachys lavandulifolia on Pentylenetetrazole-induced Seizures in Male Mice: The Role of GABAergic and Opioidergic Systems

open access: yesBasic and Clinical Neuroscience, 2022
Introduction: Epilepsy is one of the most common neurological disorders. Though there are several effective drugs for treating epilepsy, most drugs are associated with side effects and drug interactions. Stachys lavandulifolia used in Iranian traditional
Hamid Behzadnia   +5 more
doaj  

The Metabolic Fate of Pentylenetetrazol in the Rat

open access: yesCanadian Journal of Physiology and Pharmacology, 1971
Pentylenetetrazol administered to rats was metabolized to a derivative which was excreted in the urine along with unchanged pentylenetetrazol. Pentylenetetrazol and its metabolite can be separated on paper chromatograms developed in water-saturated isobutanol. The substances, however, are chromatographically inseparable with water as the mobile phase.
G K, Ko, E A, Hosein
openaire   +3 more sources

Anticonvulsant and antioxidant activities of crude flavonoid extract of Matricaria chamomilla L. against convulsions induced by pentylenetetrazole in chicks [PDF]

open access: yesIraqi Journal of Veterinary Sciences, 2022
In the current study, crude flavonoid extract ofMatricaria chamomilla L. (MC) was used to evaluate anticonvulsant, and antioxidant activities on pentylenetetrazole (PTZ) induced convulsion in chicks. The biochemical estimation was done by measuring brain
Suleiman D. Suleiman, Jian S. Hassan
doaj   +1 more source

Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Potential Anticonvulsant Agents

open access: yesMolecules, 2016
New benztriazoles with a mercapto-triazole and other heterocycle substituents were synthesized and evaluated for their anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ), and rotarod
Da-Chuan Liu   +3 more
doaj   +1 more source

Neuroprotective role of acamprosate and rasagiline in epilepsy: In silico and in vivo study [PDF]

open access: yesScripta Medica
Background/Aim: Current treatments for epilepsy have only indicative relief without smashing the pathological trademarks of the disease. The unmet need is to find new therapeutic active drug candidates for effective management of epilepsy and associated ...
Kumar Sandeep   +7 more
doaj   +1 more source

Effect of Stachys lavandulifolia on Pentylenetetrazole-Induced Seizures, Passive Avoidance Learning, and Oxidative Stress in Male Wistar Rats

open access: yes, 2022
Objective:Mountain tea with the scientific moniker of Stachys lavandulifolia has been used in traditional medicine for osteoarthritis and rheumatic disorders.
Vahid Azizi   +3 more
core   +1 more source

The Effect of Low-Doses of Caffeine and Taurine on Convulsive Seizure Parameters in Rats

open access: yesBehavioral Sciences, 2020
Introduction: Caffeine, an adenosine-receptor blocker, is believed to have neuronal excitatory effects, while Taurine, a mammalian amino acid, was shown to have neuroinhibitory effects.
Mohamed Jailani   +9 more
doaj   +1 more source

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