Results 11 to 20 of about 9,677 (229)

Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABA_A Receptor and Voltage-Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies. [PDF]

Brain Behav
Citronellal, daidzin, and phytol exert significant anticonvulsant effects in a chick seizure model by enhancing GABAergic transmission and blocking voltage‐gated sodium channels, with combination therapies showing enhanced efficacy and a favorable safety profile.
Mia E, Rahman MA, Shipon MNH, Mou MA, Mandal P, Rakib IH, Sayeed MA, Islam MT, Al Hasan MS, Ansari MA.   +9 more
europepmc   +2 more sources

Nanoparticle-encapsulated neuropeptide Y provides robust seizure protection in SCN1A-derived epilepsy. [PDF]

Epilepsia
Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Reed SL, Aiani LM, Faiz E, Adediran E, Benveniste M, Murnane KS, D'Souza M, Escayg A, Wong JC.   +8 more
europepmc   +2 more sources

Olig2-specific loss-of-function Slc35a2 results in hypomyelination and spontaneous seizures. [PDF]

Epilepsia
Abstract Objective Malformations of cortical development represent major causes of drug‐resistant epilepsy, with mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy recognized as a distinct pathological entity. Pathogenic X‐linked SLC35A2, encoding the uridine diphosphate–galactose transporter, has been implicated ...
Bartel TM, Ghosh C, Bisaha K, Khoury J, Nemes-Baran A, Blumcke I, Najm I.   +6 more
europepmc   +2 more sources

The Effect of Hydroalcoholic Extract of Salep on Pentylenetetrazole-Induced Seizure in Adult Male Rats [PDF]

Iranian Journal of Neurosurgery, 2023
Background and Aim: Epilepsy as a neurological disorder is characterized by unpredictable and periodic seizures. In the present study, the anticonvulsant effect of different doses of salep hydroalcoholic extract on pentylenetetrazole (PTZ) induced ...
Hossein Kargar Jahromi , Arman Khorram, Shekofeh Atashpoor, Maryam Jalali, Zahra Kargar Jahromi, Fatemeh Mohammadi, Mohammad Amin Serpoosh, Najmeh Sadeghi   +7 more
doaj  

Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]

, 2014
Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core   +1 more source

Effects of L-carnitine and Ginkgo bilobaon cerebral cortex in experimentally-induced epileptic seizures disease in rat [PDF]

Journal of Bioscience and Applied Research, 2015
Pentylenetetrazole (PTZ) kindling is an acknowledged model for epilepsy and refers to a phenomenon in which repeated injection of this drug causes a gradual seizure. The current study aimed to determine the possible protective and ameliorative effects of
Ehab Tousson, Mohamed F.F Bayomy, Basiouny Fouad El-sendiony   +2 more
doaj   +1 more source

A Novel Long-term, Multi-Channel and Non-invasive Electrophysiology Platform for Zebrafish. [PDF]

, 2016
Zebrafish are a popular vertebrate model for human neurological disorders and drug discovery. Although fecundity, breeding convenience, genetic homology and optical transparency have been key advantages, laborious and invasive procedures are required for
Baraban, Scott C, Hong, SoonGweon, Lee, Luke P, Lee, Philip   +3 more
core   +1 more source

Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors [PDF]

, 2010
Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (
Cursons, Raymond T., Jacobson, Gregory M., Mason, Jonathan P., Melin, Sofia M., Sleigh, James W., Steyn-Ross, D. Alistair, Steyn-Ross, Moira L., Voss, Logan J.   +7 more
core   +2 more sources

Reference Gene Validation in the Brain Regions of Young Rats after Pentylenetetrazole-Induced Seizures

Biomedicines, 2020
Reverse transcription followed by quantitative polymerase chain reaction (qRT-PCR) is a powerful and commonly used tool for gene expression analysis. It requires the right choice of stably expressed reference genes for accurate normalization.
Alexander P. Schwarz, Anna A. Kovalenko, Daria A. Malygina, Tatiana Y. Postnikova, Olga E. Zubareva, Aleksey V. Zaitsev   +5 more
doaj   +1 more source

Effects Of 4-thiazolidinone Derivatives Les-2658 And Les-1205 On Sleep - Wakefulness Cycle In Kindled Rats [PDF]

, 2017
The research is dedicated to in-depth study of neurotrophic and antiepileptic properties of original potential anticonvulsant agents from 4-thiazolidinones – LES-2658 (5-(3-nitro-benzylidene)-2-(thiazol-2-ylimino)-thiazolidin-4-one) and LES-1205 ([2,4 ...
Lesyk, R. (Roman), Myronenko, S. (Solomija), Pinyazhko, O. (Oleh)   +2 more
core   +2 more sources