Results 11 to 20 of about 6,209 (222)
EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line [PDF]
Frontiers in Cellular Neuroscience, 2023 BackgroundTransient receptor potential (TRP) channels have been found to have significant implications in neuronal outgrowth, survival, inflammatory neurogenic pain, and various epileptogenic processes.
Ishak Suat Ovey +7 more
doaj +2 more sources
Bangladesh Journal of Pharmacology, 2019 The purpose of this study was to investigate the effect of hydroalcoholic extract of Artemisia persica (100, 200 and 400 mg/kg) on pentylenetetrazole-induced seizure and memory impairment. Sixty mice were assigned to seven groups.
Mozhgan Daneshkhah, Mahbubeh Setorki
doaj +4 more sources
Biomolecules & Biomedicine, 2013 Epilepsy is one of the most common neurological disorders, characterized by recurrent seizures, which may increase the content of reactive oxygen and nitrogen species.
Hale Maral Kir +4 more
doaj +4 more sources
Pentylenetetrazol Kindling Epilepsy Model
Journal of the Turkish Epilepsi Society, 2015 Epilepsy is one of the most common neurologic disorders affecting approximately 1% of the general population, and no alleviation was achieved in one third of the patients medicated with antiepileptic drugs. Current treatments of epilepsy are symptomatic and have more anti-seizure effects than antiepileptic effects. These therapies do not cure epilepsy.
Arihan, Okan, Erkeç, Özlem Ergül
openaire +3 more sources
Biomedicines, 2020 Reverse transcription followed by quantitative polymerase chain reaction (qRT-PCR) is a powerful and commonly used tool for gene expression analysis. It requires the right choice of stably expressed reference genes for accurate normalization.
Alexander P. Schwarz +5 more
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Chronic sleep deprivation promotes drug-resistant epilepsy via the BMAL1-mTOR-P-gp axis. [PDF]
Epilepsia OpenAbstract Objective The interplay between chronic sleep deprivation and drug‐resistant epilepsy (DRE) has gained increasing attention. Brain and muscle Arnt‐like protein 1 (BMAL1), which is implicated in sleep disturbance, has an unclear role in DRE. We aimed to investigate the role of BMAL1 in sleep deprivation‐induced DRE. Methods A pentylenetetrazole
Wang X +7 more
europepmc +2 more sources
Effect of Deep Brain Stimulation in The Ventral Tegmental Area on Neuronal Activity in Local and Remote Brain Regions in Kindled Mice [PDF]
Cell Journal, 2023 Objective: The mechanisms behind seizure suppression by deep brain stimulation (DBS) are not fully revealed, andthe most optimal stimulus regimens and anatomical targets are yet to be determined. We investigated the modulatoryeffect of low-frequency DBS (
Parisa Esmaeili Tazangi +5 more
doaj +1 more source
Acta Medica Iranica, 2016 Ryanodine receptor abnormalities has implicated in the generation and maintenance of seizure. Dantrolene, a selective ryanodine receptor antagonist, may be a potential drug for the prevention of seizure.
Mojtaba Keshavarz +2 more
doaj +1 more source
Effects of Hydro-ethanolic Extract of Tanacetum parthenium and its N-Butanol and Aqueous Fractions on Brain Oxidative Damage in Pentylenetetrazole-Induced Seizures in Mice [PDF]
Pharmaceutical Sciences, 2020 Background: Epileptic seizures affect the life of noticeable number of people in all over the world. Tanacetum parthenium (TP) is used in traditional medicine.
Fereshteh Asgharzadeh +8 more
doaj +1 more source
Acute and Sub-chronic Anticonvulsant Effects of Edaravone on Seizure Induced by Pentylenetetrazole or Electroshock in Mice, Nitric Oxide Involvement [PDF]
Iranian Journal of Medical Sciences, 2023 Background: Edaravone is an anti-stroke medication that may have nitric oxide (NO) modulating properties. This study evaluated the role of NO in the acute and sub-chronic anticonvulsant effects of edaravone in murine models of seizures induced by ...
Leila Moezi +5 more
doaj +1 more source