Special Issue on the Promise of Psychedelic Pharmacology in Neuropsychiatric Drug Development [PDF]
Pharmacol Res PerspectPharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
Andreas Halman, Ross Corriden
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Intestinal Klebsiella pneumoniae enhances neuroinflammation and seizure susceptibility in a pentylenetetrazole-induced acute seizure model [PDF]
Frontiers in NeuroscienceEpilepsy is characterized by recurrent seizures and is driven in part by neuroinflammation-induced disruption of neuronal excitation-inhibition (E/I) balance. However, the upstream factors triggering microglial activation remain unclear.
Junqiang Li +9 more
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Pentylenetetrazol Kindling Epilepsy Model
Journal of the Turkish Epilepsi Society, 2015 Epilepsy is one of the most common neurologic disorders affecting approximately 1% of the general population, and no alleviation was achieved in one third of the patients medicated with antiepileptic drugs. Current treatments of epilepsy are symptomatic and have more anti-seizure effects than antiepileptic effects. These therapies do not cure epilepsy.
Arihan, OKAN, Erkeç, Özlem Ergül
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Acrylamide‐Induced Developmental and Molecular Toxicity in Drosophila melanogaster: The Role of Vanillic Acid in CncC/Keap1 Modulation [PDF]
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.Vanillic acid, a dietary phenolic, dose‐dependently protects Drosophila melanogaster from acrylamide‐induced oxidative damage, DNA strand breaks, and developmental toxicity by modulating CncC/Keap1 redox signaling—establishing vanillic acid as a candidate natural protective agent against a major environmental contaminant.
Fahriye Zemheri‐Navruz +2 more
wiley +2 more sources
Acta Medica Iranica, 2016 Ryanodine receptor abnormalities has implicated in the generation and maintenance of seizure. Dantrolene, a selective ryanodine receptor antagonist, may be a potential drug for the prevention of seizure.
Mojtaba Keshavarz +2 more
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EFFECT OF NICORANDIL ON PENTYLENETETRAZOLE (PTZ) INDUCED CONVULSIONS IN MICE [PDF]
, 2015 Aims & Objectives: To evaluate or screen the anticonvulsant effect of Nicorandil a potassium channel opener in Pentylenetetrazole(PTZ) induced convusions in albino mice.
Ambadasu, Bharatha +4 more
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Effects of L-carnitine and Ginkgo bilobaon cerebral cortex in experimentally-induced epileptic seizures disease in rat [PDF]
Journal of Bioscience and Applied Research, 2015 Pentylenetetrazole (PTZ) kindling is an acknowledged model for epilepsy and refers to a phenomenon in which repeated injection of this drug causes a gradual seizure. The current study aimed to determine the possible protective and ameliorative effects of
Ehab Tousson +2 more
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Biomedicines, 2020 Reverse transcription followed by quantitative polymerase chain reaction (qRT-PCR) is a powerful and commonly used tool for gene expression analysis. It requires the right choice of stably expressed reference genes for accurate normalization.
Alexander P. Schwarz +5 more
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Pentylenetetrazole Kindling Affects Sleep in Rats [PDF]
Epilepsia, 2006 Summary: Purpose: The aim of the study was to define sleep disturbances in pentylenetetrazole (PTZ)‐kindled rats and to explore the effects of the nootropic drug piracetam (Pir; 100 mg/kg) and the noncompetitive N‐methyl‐d‐aspartate (NMDA)‐antagonist MK‐801 (0.3 mg/kg), which normalized learning performance in PTZ‐kindled rats, on altered sleep ...
Markus, Schilling +3 more
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Gender differences in a Drosophila transcriptomic model of chronic pentylenetetrazole induced behavioral deficit [PDF]
, 2009 A male Drosophila model of locomotor deficit induced by chronic pentylenetetrazole (PTZ), a proconvulsant used to model epileptogenesis in rodents, has recently been described.
Abhay Sharma +8 more
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