Results 71 to 80 of about 7,019 (224)

Evaluation of the anticonvulsant activity of the essential oil of Myrothamnus moschatus in convulsion induced by pentylenetetrazole and picrotoxin [PDF]

, 2016
Objective: To evaluate the anticonvulsant effect of the essential oil of Myrothamnus moschatus (M. moschatus) in convulsion induced by pentylenetetrazole and picrotoxin in rodent models. Methods: The essential oil of the aerial parts of M. moschatus was
Randrianarivo, Emmanuel, Nicoletti, Marcello, Emmanuel Randrianarivo, Rasoanaivo, Philippe, MAGGI, Filippo, Filippo Maggi, Philippe Rasoanaivo, Marcello Nicoletti   +7 more
core   +1 more source

Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease

MedComm, Volume 7, Issue 9, September 2026.
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi, Dongping Yao, Chanjuan Dong, Xiao Tu, Guojian Liao, Mengfei Long, Yongmei Xie   +6 more
wiley   +1 more source

Evidence for the Induction of Anxiolytic‐Like Behavior and Memory Preservation by (+)‐Dihydrocarvone Through Studies in Adult Zebrafish and In Sílico

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
(+)‐Dihydrocarvone exhibited anxiolytic‐like and memory‐preserving effects in adult zebrafish. Behavioral assays showed reduced anxiety and improved cognitive performance, while in silico docking revealed strong interactions with GABAergic and cholinergic targets. These findings suggest (+)‐dihydrocarvone as a promising neuroactive compound for anxiety
Isadora Freitas de Sousa, Francisco Rogênio da Silva Mendes, Maria Kueirislene Amâncio Ferreira, Antônio Wlisses da Silva, Leticia Souza da Silva, Jane Eire Silva de Alencar Menezes, Márcia Machado Marinho, Emmanuel Silva Marinho, Matheus Nunes da Rocha, Antônio César Honorato Barreto, Alexandre Magno Rodrigues Teixeira, Hélcio Silva dos Santos   +11 more
wiley   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, Volume 67, Issue 8, Page 4292-4304, August 2026.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

The Effect of Aerobic Exercise Training on Epileptic Behaviors in the Kindled and Non-Kindled Rats with Pentylenetetrazole (PTZ)

مجله دانشکده پزشکی اصفهان, 2020
Background: Exercise can be a supplementary therapy to treat seizures. However, there is little information on the extent of these effects in seizure-susceptible individuals.
Mehdi Zarei, Rahim Golmohammadi, Seyed Mehdi Beheshti-Nasr   +2 more
doaj   +1 more source

Distinct patterns of electrical stimulation of the basolateral amygdala influence pentylenetetrazole seizure outcome [PDF]

, 2009
Our working hypothesis is that constant interpulse interval (IPI) electrical stimulation would resonate with endogenous epileptogenic reverberating circuits, inducing seizures, whereas a random interinterval electrical stimulation protocol would promote ...
Cota, Vinícius Rosa, da Páscoa Vilela, Maura Regina Silva, Moraes, Márcio Flávio Dutra, Doretto, Maria Carolina, de Castro Medeiros, Daniel   +4 more
core   +1 more source

Impact of Gastrodia elata on Neuroinflammation and Epilepsy in a Rat Model

Medical Journal of Babylon
Background: Gastrodia elata (GE) is a traditional Chinese herb, a type of Orchidaceae, which has antiepileptic and anti-inflammatory effects. Objectives: To investigate the impact of GE on behavioral changes and inflammation after induction of seizures ...
Noor-Alhuda Mohammed Alebadi, Reyadh H. Al-Mosawi, Mufeed Jalil Ewadh   +2 more
doaj   +1 more source

Sodium‐glucose cotransporter 2 inhibitors and the risk of late onset epilepsy: A real‐world cohort study

Epilepsia, Volume 67, Issue 7, Page 3444-3456, July 2026.
Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin, Hui‐Min Huang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, Volume 67, Issue 6, Page 3199-3210, June 2026.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Preparation and Evaluation of Carbamazepine Solid Lipid Nanoparticle for Alleviating Seizure Activity in Pentylenetetrazole-Kindled Mice

Molecules, 2019
Objectives: The study aimed to prepare carbamazepine in solid lipid nanoparticle form (CBZ-SLN) in order to enhance its anticonvulsant effect. Method: Eight formulations of CBZ-SLNs were prepared by homogenization and ultra-sonication techniques. Results:
Mona Qushawy, Kousalya Prabahar, Mohammed Abd-Alhaseeb, Shady Swidan, Ali Nasr   +4 more
doaj   +1 more source