Results 81 to 90 of about 6,209 (222)

The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line

, 2021
Recent studies have shown that proton pump inhibitors have positive effects on the nervous system. However, its effect on epileptic seizure and neuronal damage are still unclear.
Sahin, Bilal, Ozturk, Aysegul, Gunes, Handan, Ozdemir, Ercan, Taskiran, Ahmet Sevki, Ergul, Mustafa   +5 more
core   +1 more source

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source

Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats [PDF]

, 2002
Venlafaxine, an atypical antidepressant drug, has been used to treat several neurological disorders, presenting excellent efficacy and tolerability. Clinical seizures after venlafaxine treatment have occasionally been reported when the drug was used at ...
Russi, M., F.H.M. Do Monte, Lanziotti, Vanusa Maria Nascimento Bispo, Santos Junior, J.G., J.G. Santos Junior, Santos-Junior, Jair Guilherme [UNIFESP], V.M.N.B. Lanziotti, Do Monte, F.h.m., Lanziotti, V.M.N.B., M. Russi, Agustine, P.e., P.E. Agustine   +11 more
core   +1 more source

Absence epilepsy and regional blood-brain barrier permeability: The effects of pentylenetetrazole-induced convulsions

, 1999
This study was designed to evaluate the blood-brain barrier permeability characteristics of the WAG/Rij strain of rats that are an ideal model for human absence epilepsy, in controls and pentylenetetrazole-induced seizures conditioned to Evans blue ...
Ates, NURBAY, Ilbay, GÜL, Esen, N
core   +1 more source

_Drosophila_ and human transcriptomic data mining provides evidence for therapeutic mechanism of pentylenetetrazole in Down syndrome

, 2010
Pentylenetetrazole (PTZ) has recently been found to ameliorate cognitive impairment in rodent models of Down syndrome (DS). The mechanism underlying PTZ’s therapeutic effect is however not clear.
Abhay Sharma
core  

Inhibitory GABAergic Neuron Loss due to Oxidative Damage During Ex Vivo Acute Brain Slice Preparation Influences Genesis and Dynamics of Epileptiform Activity

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Ex vivo brain slice preparation is a popular technique in neuroscience research with many variations in preparation method. We compared two popular variations in brain slice preparation and found that the choice of brain slice preparation technique significantly affects the viability of neuronal preparation.
Felix Chan, Anupam Hazra, Ashan Jayasekera, Katherine Huang, Shuna Whyte, Leolie Telford‐Cooke, Kamilah Lakhani, Xiaomeng Li, Rebecca Shields, Angeline Kosim, Darwin Su, Carol Murray, Mark O. Cunningham   +12 more
wiley   +1 more source

Impact of Gastrodia elata on Neuroinflammation and Epilepsy in a Rat Model

Medical Journal of Babylon
Background: Gastrodia elata (GE) is a traditional Chinese herb, a type of Orchidaceae, which has antiepileptic and anti-inflammatory effects. Objectives: To investigate the impact of GE on behavioral changes and inflammation after induction of seizures ...
Noor-Alhuda Mohammed Alebadi, Reyadh H. Al-Mosawi, Mufeed Jalil Ewadh   +2 more
doaj   +1 more source

Preparation and Evaluation of Carbamazepine Solid Lipid Nanoparticle for Alleviating Seizure Activity in Pentylenetetrazole-Kindled Mice

Molecules, 2019
Objectives: The study aimed to prepare carbamazepine in solid lipid nanoparticle form (CBZ-SLN) in order to enhance its anticonvulsant effect. Method: Eight formulations of CBZ-SLNs were prepared by homogenization and ultra-sonication techniques. Results:
Mona Qushawy, Kousalya Prabahar, Mohammed Abd-Alhaseeb, Shady Swidan, Ali Nasr   +4 more
doaj   +1 more source

Prefrontal TRPM8 Receptor Modulates Epileptic Seizures via PKA/CREB Signaling Pathway in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Jia‐zhan Huang et al. describe a function of prefrontal TRPM8 in the regulation of epileptic seizures. TRPM8 receptors was upregulated in the prefrontal cortex (PFC) of epileptic mice. Inhibition or knockdown of TRPM8 in PFC can effectively prolong the latency and reduce the level of seizures in mouse models induced by pentatetrazole. At the same time,
Jia‐Zhan Huang, Gui‐Feng Lu, Yi‐Han Jiang, Yao Guo, Ze‐Yu Lin, Zhi Zhang, Fei Geng   +6 more
wiley   +1 more source

BETMB: A Dual‐Target Compound for Synergistic Suppression of Neuronal Hyperexcitability in Refractory Epilepsy via Concurrent Modulation of Nav Channels and GABAA Receptors

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
BETMB exerts multi‐target effects by positively modulating GABAARs and blocking NaV channels in a state‐dependent manner. This suppresses neuronal hyperexcitability, leading to seizure control and restoration of cognitive function. ABSTRACT Aims This study aims to evaluate 5‐(but‐1‐en‐1‐yl)‐1,2,3‐trimethoxybenzene (BETMB) as a novel dual‐target anti ...
Di Zhang, Kai Li, Yingying Zhang, Yao Nie, Yue Li, Rui Li, Xin Wang, Shengjun Mao   +7 more
wiley   +1 more source