Results 81 to 90 of about 9,677 (229)

Effect of Estradiol and Soy Extract on the Onset of PTZ-Induced Seizure in Ovariectomized Rats: Implications for Nurses and Midwives [PDF]

, 2016
Background: In many epileptic women, the ovarian cycle influences the risk and severity of seizures. Previous studies have reported inconsistent findings regarding the neural excitatory effects of estrogen.
Afsordeh, N., Arbabi, E., Hamidi, G.A., Heydari, A., Karimi, S., Sadat Alavi, S., Salami, M.   +6 more
core   +1 more source

Clinical considerations in transitioning patients with epilepsy from clonazepam to clobazam: a case series. [PDF]

, 2014
IntroductionIn treating refractory epilepsy, many clinicians are interested in methods used to transition patients receiving clonazepam to clobazam to maintain or increase seizure control, improve tolerability of patients' overall drug therapy regimens ...
Chung, Steve, Kuzniecky, Ruben, Perry, Michael Scott, Sankar, Raman, Sinha, Saurabh   +4 more
core   +1 more source

Preparation and Evaluation of Carbamazepine Solid Lipid Nanoparticle for Alleviating Seizure Activity in Pentylenetetrazole-Kindled Mice

Molecules, 2019
Objectives: The study aimed to prepare carbamazepine in solid lipid nanoparticle form (CBZ-SLN) in order to enhance its anticonvulsant effect. Method: Eight formulations of CBZ-SLNs were prepared by homogenization and ultra-sonication techniques. Results:
Mona Qushawy, Kousalya Prabahar, Mohammed Abd-Alhaseeb, Shady Swidan, Ali Nasr   +4 more
doaj   +1 more source

Phytocannabinoids as novel therapeutic agents in CNS disorders [PDF]

, 2012
The Cannabis sativa herb contains over 100 phytocannabinoid (pCB) compounds and has been used for thousands of years for both recreational and medicinal purposes.
Hill, Andrew J., Stephens, Gary J., Whalley, Benjamin J., Williams, Claire M.   +3 more
core   +1 more source

Impact of Gastrodia elata on Neuroinflammation and Epilepsy in a Rat Model

Medical Journal of Babylon
Background: Gastrodia elata (GE) is a traditional Chinese herb, a type of Orchidaceae, which has antiepileptic and anti-inflammatory effects. Objectives: To investigate the impact of GE on behavioral changes and inflammation after induction of seizures ...
Noor-Alhuda Mohammed Alebadi, Reyadh H. Al-Mosawi, Mufeed Jalil Ewadh   +2 more
doaj   +1 more source

Memantine Confers Multi‐Target Protection in a Zebrafish Seizure Model: Attenuating Epileptic Behavior, GluN2A Overexpression, and Oxidative Stress

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Approximately 30% of epilepsy patients do not respond to current medications. In addition, the pharmaceutical industry is reducing its interest in de novo drug discovery for epilepsy. Drug repurposing offers a promising alternative. This study investigated memantine, an Alzheimer's drug, in a zebrafish model of seizures.
Kamila Cagliari Zenki, Eduardo Kalinine, Ben Hur Marins Mussulini, Thainá Garbino dos Santos, Lucia von Mengden, Fábio Klamt, Suelen Baggio, Ana Carolina de Moura, Ana Beatriz Gorini da Veiga, Diogo Losch de Oliveira   +9 more
wiley   +1 more source

Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study. [PDF]

, 2014
Backgroundn-3 fatty acids inhibit neuronal excitability and reduce seizures in animal models. High-dose fish oil has been explored in two randomised trials in drug resistant epilepsy with negative results.
DeGiorgio, Christopher M, Gornbein, Jeffrey, Harper, Ronald, Meymandi, Sheba, Miller, Patrick R, Schrader, Lara, Soss, Jason   +6 more
core   +1 more source

Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice [PDF]

, 2012
The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water.
Ahmad, Shiekh Tanveer, Asiaf, Asia, Aslam, Mohammad, Bhat, Jalal Uddin, Khanam, Razia, Mujeeb, Mohammad, Nizami, Qudsia, Parray, Shabir Ahmad, Siddiqui, Aisha, Umar, Sadiq   +9 more
core  

Neuroprotective actions of ghrelin and growth hormone secretagogues [PDF]

, 2011
The brain incorporates and coordinates information based on the hormonal environment, receiving information from peripheral tissues through the circulation.
Laura M. Frago, Laura M. Frago, Laura M. Frago, Laura M. Frago, Eva eBaquedano, Eva eBaquedano, Eva eBaquedano, Eva eBaquedano, Jesús eArgente, Jesús eArgente, Jesús eArgente, Jesús eArgente, Julie A Chowen, Julie A Chowen, Julie A Chowen   +14 more
core   +1 more source

Effect of acute L-carnitine administration alone or combination with sodium valproate on pentylenetetrazole- induced seizures in mice

Fiyz̤, 2021
Background: L-carnitine, as an endogenous compound, has paradoxical effects on seizures. This study aimed to evaluate the effect of acute administration of L-carnitine alone or combination with sodium valproate on pentylenetetrazole (PTZ) induced ...
Morteza Vaghefi-Esfidani, Azhdar Heydari
doaj