Results 101 to 110 of about 9,677 (229)

Effects of Pentachlorophenol, Pentylenetetrazol and Carnitine on Mitochondria

Journal of UOEH, 1998
Pentachlorophenol (PCP) increased oxygen consumption and lowered the respiratory control ratio (RCR) in mitochondria from rat liver. These effects of PCP were lessened by 1 mM L-carnitine but not by D-carnitine. In contrast, up to 150 mM of pentylenetetrazol (PTZ) added at state 4 of respiration did not accelerate oxygen consumption.
Z, Yu, Y, Iryo, M, Matsuoka, H, Igisu
openaire   +3 more sources

The effect of Salvia officinalis hydroalcoholic extract on PTZ-induced seizure threshold in Vincristine injected mice [PDF]

, 2012
and aims: Studies show that Vincristine is an anti-cancer drug which has neuropathic effects. Some studies have shown that Salvia officinalis has therapeutic effects on nervous system.
Namvaran Abbasabad, Ali., Tavakkoli Ghazani, Farzaneh.   +1 more
core  

Synthesis of 5-Alkoxythieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine Derivatives and Evaluation of Their Anticonvulsant Activities

Molecules, 2015
This work concerns the design and synthesis of novel, substituted 5-alkoxythieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 5a–p prepared from 3-amino-2-thiophenecarboxylic acid methyl ester.
Shi-Ben Wang, Guang-Chun Piao, Hong-Jian Zhang, Zhe-Shan Quan   +3 more
doaj   +1 more source

How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]

, 2014
Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano, Talevi, Alan   +1 more
core   +1 more source

Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice [PDF]

, 2015
Histamine regulates release of neurotransmitters such as dopamine, serotonin, gamma-aminobutyric acid (GABA), glutamate and also is involved in several functions in central nervous system (CNS).
Alijanpour, Sakineh., Amini-Khoei, Hossein., Amiri, Shayan., Dehpour, Ahmad Reza., Ejtemaie Mehr, Shahram., Gooshe, Maziar., Haj-Mirzaian, Arya., Hassanipour, Mahsa., Rahimi-Balaei, Maryam., Shirzadian, Armin.   +9 more
core  

Antiepileptic activity of hydroalcoholic extract of basil in mice [PDF]

, 2014
Introduction: Epilepsy has been always considered as one of the most prevalent disorders of nervous system and despite various drugs available, there are still some patients who have drug resistance.
Asadi-Samani, Majid., Modaresi, Mehrdad., Pouriyanzadeh, Arezoo.   +2 more
core  

The effect of cyclooxygenase-2 inhibition on pentylenetetrazole-induced seizure threshold in mice [PDF]

, 2018
Background: Previous studies have shown the protective effect of cyclooxygenase (COX) enzyme in development of convulsions. However, involvement of COX-2 in the pathogenesis of epilepsy is not yet well-known. The present study was designed to investigate
Heydari, Azhdar, Khazaee, Paria, Mesdaghinia, Azam   +2 more
core  

Investing the anti epileptic effect of Aqueous extract of Artemisia absinthium on seizures induced by pentylenetetrazole in male rats [PDF]

Complementary Medicine Journal of Faculty of Nursing and Midwifery
Introduction:Epilepsy is one of the most common neurological disorders that affect social, economic, and biological aspects of human life. Thus, this study aimed to investigate the effect of Aqueous extract of Artemisia absinthium on PTZ-induced seizures
Masoumeh Gholami, Mehdi Sadegh
doaj  

Effects of Intracerebroventricular Injection of Alcoholic Extract of hawthorn (Crataegus melano carpa) Leaves on Fear Behavior in Presence Pentylenetetrazole (PTZ) in Adult Male Rat

Journal of Medicinal Plants, 2012
Background: In traditional medicine "Crataegus melanocarpa" is one of the medicinal plants that has many therapeutic effects. One of them is its effect on nerveous system.
P Darabi, B Tavakoli-far, Gh Vaezi, K Keramati   +3 more
doaj  

Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice

Frontiers in Pharmacology
BackgroundEpilepsy is a neurological disorder characterized by recurrent seizures due to abnormal electrical activity in the brain. Pirfenidone, an antifibrotic drug, has shown anti-inflammatory and antioxidant properties in various disease models ...
Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi   +4 more
doaj   +1 more source