Results 101 to 110 of about 6,209 (222)

Synthesis of 5-Alkoxythieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine Derivatives and Evaluation of Their Anticonvulsant Activities

Molecules, 2015
This work concerns the design and synthesis of novel, substituted 5-alkoxythieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 5a–p prepared from 3-amino-2-thiophenecarboxylic acid methyl ester.
Shi-Ben Wang, Guang-Chun Piao, Hong-Jian Zhang, Zhe-Shan Quan   +3 more
doaj   +1 more source

Effects of Pentachlorophenol, Pentylenetetrazol and Carnitine on Mitochondria

Journal of UOEH, 1998
Pentachlorophenol (PCP) increased oxygen consumption and lowered the respiratory control ratio (RCR) in mitochondria from rat liver. These effects of PCP were lessened by 1 mM L-carnitine but not by D-carnitine. In contrast, up to 150 mM of pentylenetetrazol (PTZ) added at state 4 of respiration did not accelerate oxygen consumption.
Z, Yu, Y, Iryo, M, Matsuoka, H, Igisu
openaire   +3 more sources

Noninvasive Transcranial Focal Stimulation Via Tripolar Concentric Ring Electrodes Lessens Behavioral Seizure Activity of Recurrent Pentylenetetrazole Administrations in Rats

, 2012
Epilepsy affects approximately 1% of the world population. Antiepileptic drugs are ineffective in approximately 30% of patients and have side effects. We have been developing a noninvasive transcranial focal electrical stimulation with our novel tripolar
Liu, Xiang, Besio, Walter G., Rogel-Salazar, Gabriela, Luna-Munguía, Hiram, Makeyev, Oleksandr   +4 more
core   +1 more source

Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish

, 2013
SUMMARY Neural stimulation can reduce the frequency of seizures in persons with epilepsy, but rates of seizure-free outcome are low. Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the ...
Charles W. Hall, Christine E. Beattie, Ricardo Pineda   +2 more
core   +1 more source

Interaction between carbenoxolone and valproic acid on pentylenetetrazole kindling model of epilepsy

, 2015
Gap junctions play an important role in the synchronized neuronal discharges. The main reason of the epileptic seizures is disruption of this synchronization.
Sefil, Fatih, Bostancı, Mehmet Ömer, Bağırıcı, Faruk, Kozan, Ramazan, Arık, Aliye E., Acar, Meryem D.   +5 more
core   +1 more source

Experimental evaluation of anticonvulsant effect of human placental extract in pentylenetetrazole induced convulsions in mice

, 2017
Background: Human placental extract (HPE) is used in different clinical conditions. Human placental extract (HPE), a folklore medicine, prepared from fresh, healthy human placenta has been in use, as single dose therapy in the treatment of epilepsy in ...
G., Sam Pavan Kumar, Chinnam, Pushpalatha, S., Avanthi, Rao, Gundappa S., Mohsin, Mohd.   +4 more
core  

The Influence of the Hydroalcoholic Extract of Polypodium vulgare L. on Pentylenetetrazole-induced Seizures and Its Comparison with the Impact of Sodium Valproate in a Rat Model [PDF]

Objective: Epilepsy affects over 1% of the global population. Polypodium vulgare L. has emerged in studies, suggesting its potential antiepileptic effect.
Shiva Shaker, Amirali Ebrahim Babaei, Manzarbanoo Shojaeifard   +2 more
core   +1 more source

Participação da substância cinzenta periaquedutal dorso-lateral na modulação do efeito ansiogênico do pentilenotetrazol em ratos submetidos ao labirinto em cruz elavado [PDF]

, 2005
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmacologia.Estudos prévios demonstraram que a administração sistêmica de [pentilenotetrazol] (PTZ) causa uma redução da exploração dos ...
Anzini, Cláudia
core  

Anticonvulsant and antioxidant activity of aqueous leaves extract of Desmodium triflorum in mice against pentylenetetrazole and maximal electroshock induced convulsion

, 2013
The present investigation was aimed to study an anticonvulsant activity of aqueous extract of Desmodium triflorum (L.) DC., Fabaceae, in mice. Animal models of epilepsy namely the pentylenetetrazole, and maximal electroshock induced convulsion were used ...
Bhosle, Vaibhav
core   +1 more source

Reversal of pentylenetetrazole-induced seizure activity in mice by nickel chloride

, 2009
Objective: The present study was designed to investigate the anticonvulsant potential of nickel which is shown to selectively block t-type calcium channels by using nickel choride on pentylenetetrazole (80 mg/kg) induced seizure activity model in mice ...
Rehni, Ashish K, Singh, Nirmal
core   +1 more source