Results 101 to 110 of about 7,019 (224)

Chrysophanol attenuates cognitive impairment, neuroinflammation, and oxidative stress by TLR4/NFκB-Nrf2/HO-1 and BDNF/VEGF signaling in stress-intensified PTZ induced epilepsy in mice

Frontiers in Pharmacology
BackgroundStress is among the most common comorbid conditions with epilepsy and a strong factor in the pathophysiology of seizures. An imbalance in neuronal circuits causes recurrent unprovoked seizures in epilepsy. Dysregulation of BDNF/VEGF expression,
Jehan Zeb Khan, Syeda Rida Zainab, Mujeeb Ur Rehman, Muhammad Abid, Fawad Ali Shah, Najeeb Ur Rehman, Muhammad Khalid Tipu   +6 more
doaj   +1 more source

Effect of Gallic Acid on PTZ-induced Neurotoxıcıty, Oxidative Stress and Inflammation in SH-SY5Y Neuroblastoma Cells

Acta Medica Alanya
Aim: Human neuroblastoma cell lines are widely used to elucidate the cellular and molecular mechanisms of neurotoxicants and to facilitate the prioritization of in vivo testing. Pentylenetetrazole (PTZ) is a tetrazole derivative. Although PTZ is the most
Yener Yazğan
doaj   +1 more source

Investing the anti epileptic effect of Aqueous extract of Artemisia absinthium on seizures induced by pentylenetetrazole in male rats [PDF]

Complementary Medicine Journal of Faculty of Nursing and Midwifery
Introduction:Epilepsy is one of the most common neurological disorders that affect social, economic, and biological aspects of human life. Thus, this study aimed to investigate the effect of Aqueous extract of Artemisia absinthium on PTZ-induced seizures
Masoumeh Gholami, Mehdi Sadegh
doaj  

The potential anticonvulsant activity of the ethanolic extracts of Achillea nobilis and Momordica charantia in rats [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2016
Context: Currently available antiepileptic drugs have debilitating adverse effects. Natural products and plants already used in traditional medicine can be a good place to start in the search for safer and more effective options.
Gamal A. Soliman, Hasan Yusufoglu, Irem Tatli-Çankaya, Rehab F. Abdel-Rahman, Serap Aarabaci Anul, Galip Akaydn   +5 more
doaj  

Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish

, 2013
SUMMARY Neural stimulation can reduce the frequency of seizures in persons with epilepsy, but rates of seizure-free outcome are low. Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the ...
Charles W. Hall, Christine E. Beattie, Ricardo Pineda   +2 more
core   +1 more source

Anticonvulsant activity of atorvastatin against seizure induced by pentylenetetrazole and maximal electroshock in mice

, 2015
Statins are inhibitors of HMG-CoA reductase and inhibit cellular synthesis of cholesterol and isoprenoids. Studies have previously demonstrated the anti-inflammatory and vasoprotective effects of statins on cultured brain cells (astrocytes and microglia)
Mohammad Javad Khoshnoud, Samaneh Namdarian, Nader Tanideh   +2 more
core  

The pentylenetetrazole-induced activity in the hippocampus can be inhibited by the conversion of L-kynurenine to kynurenic acid: an in vitro study

, 2008
The kynurenine pathway converts tryptophan into various compounds, including L-kynurenine, which in turn can be converted into the excitatory amino acid receptor antagonist kynurenic acid.
Toldi József, Nagy Dávid, Farkas, T., Farkas Tamás, Sas, K., Rózsa, E., Vécsei László, Sas Katalin, Vécsei, L., Toldi, J., Robotka Hermina, Robotka, H., Nagy, D., Rózsa Éva   +13 more
core   +1 more source

Anticonvulsant effect of minocycline on pentylenetetrazole-induced seizure in mice: involvement of nitric oxide and N-methyl-D-aspartate receptor [PDF]

, 2017
Anticonvulsant effects of minocycline have been explored recently. This study was designed to examine the anticonvulsant effect of acute administration of minocycline on pentylenetetrazole-induced seizures in mouse considering the possible role of the ...
Amini-Khoei, Hossein, Haj-Mirzaian, Arvin, Dehpour, Ahmad Reza, Amiri, Shayan, Hasanvand, Amin, Shirzadian, Armin, Hassanipour, Mahsa, Haj-Mirzaian, Arya, Balali-Dehkordi, Shima, Kordjazy, Nastaran   +9 more
core  

Effects of Intracerebroventricular Injection of Alcoholic Extract of hawthorn (Crataegus melano carpa) Leaves on Fear Behavior in Presence Pentylenetetrazole (PTZ) in Adult Male Rat

Journal of Medicinal Plants, 2012
Background: In traditional medicine "Crataegus melanocarpa" is one of the medicinal plants that has many therapeutic effects. One of them is its effect on nerveous system.
P Darabi, B Tavakoli-far, Gh Vaezi, K Keramati   +3 more
doaj  

Anticonvulsant effects of nimodipine and two novel dihydropyridines (PCA 50922 and PCA 50941) against seizures elicited by pentylenetetrazole and electroconvulsive shock in mice

, 1998
In animal models of epilepsy, calcium entry blockers have shown anticonvulsant properties. We studied the antiepileptic effects of nimodipine and two novel dihydropyridines, a calcium antagonist (PCA 50922) and a calcium agonist (PCA 50941), on ...
Zapater, Pedro, Román, José F., Horga, José F., Vidal, Marı́a T., Javaloy, Jaime   +4 more
core   +1 more source