Results 91 to 100 of about 6,209 (222)

The effect of sulfasalazine in pentylenetetrazole-induced seizures in rats

, 2021
We aimed to reveal the anti-convulsant effects sulfasalazine and its mechanism in pentylenetetrazole (PTZ)-induced seizures in rats. Forty-eight male Wistar albino rats (200-250 g) were randomly divided into two groups: 24 for electroencephalography (EEG)
R. Karaali (12728572), E.S. Bora (12728569), P.Y. Akyol (12728575), G. Yurtsever (12728578), O. Erbaş (12728581)   +4 more
core   +1 more source

Effect of acute L-carnitine administration alone or combination with sodium valproate on pentylenetetrazole- induced seizures in mice

Fiyz̤, 2021
Background: L-carnitine, as an endogenous compound, has paradoxical effects on seizures. This study aimed to evaluate the effect of acute administration of L-carnitine alone or combination with sodium valproate on pentylenetetrazole (PTZ) induced ...
Morteza Vaghefi-Esfidani, Azhdar Heydari
doaj  

Anticonvulsant Effect of Alcea aucheri on Pentylenetetrazole and Maximal Electroshock Seizures in Mice

Basic and Clinical Neuroscience, 2020
Introduction: This study was designed to investigate the possible anticonvulsant effect of acute administration of an aqueous extract of flowers of Alcea aucheri (EFA) in two in vivo seizure models. Methods: Seizures were induced in male adult Swiss mice
Tajmah Mombeini, Babak Asadpour Behzadi, Ramtin Ejtemaei, Freidoun Tahmasbi, Mohammad Kamalinejad, Ahmad Reza Dehpour   +5 more
doaj  

Assessment of Anticonvulsant Activities of Petroleum Ether Extract of Anacyclus pyrethrum Roots on Experimental Rats

Pharmaceutical and Biomedical Research, 2020
Background: Epilepsy is one of the most common neurological conditions and a significant cause of morbidity and mortality. Objectives: The present study aimed to evaluate the anticonvulsant activity of the petroleum ether extract of the root of ...
Bashir A. Yousef, Zeinab Awad, Somaya Adam, Setalbanat Abdelgadir, Ansam Mergani   +4 more
doaj  

Effect of intraperitoneal injection of clozapine on pentylenetetrazole-kindled rats

, 2009
Background: Clozapine is one of the atypical antipsychotic drugs that is efficacious in patients unresponsive to typical antipsychotics. There are controversial evidences on convulsive effects of clozapine. This study was carried out to assess the effect
Palizvan, M.R., Chitsaz, M., Khademi, Sh.   +2 more
core  

Comparison of the Effect of Verapamil, Nifedipine and Diltiazem on Pentylenetetrazole-Induced Clonic Seizure Threshold in Mice

پزشکی بالینی ابن سینا, 2007
Background & Objective: Verapamil, nifedipine and diltiazem are calcium channel blockers widely used as a variety of cardiovascular ailment in humans. A number of studies have shown that calcium channel blockers have anticonvulsant effect in a range of ...

doaj  

ffects of morphine_ dependence on the induction and modulation of epileptic seizures in rats [PDF]

Journal of Kerman University of Medical Sciences, 1997
Kindling is a very suitable animal model for studying basis mechanisms of epilepsy. In this model , repeated exposure to weak electrical or chemical increases neuronal excitability and there fore decreases the threshold for induction of epileptic ...
N Atapour, M Niyazi
doaj  

Improving Kv7 targeting anticonvulsants ‐ will repurposing save the day?

British Journal of Pharmacology, Volume 183, Issue 3, Page 435-437, February 2026.
Nikita Gamper
wiley   +1 more source

Distinct patterns of electrical stimulation of the basolateral amygdala influence pentylenetetrazole seizure outcome [PDF]

, 2009
Our working hypothesis is that constant interpulse interval (IPI) electrical stimulation would resonate with endogenous epileptogenic reverberating circuits, inducing seizures, whereas a random interinterval electrical stimulation protocol would promote ...
Cota, Vinícius Rosa, da Páscoa Vilela, Maura Regina Silva, Moraes, Márcio Flávio Dutra, Doretto, Maria Carolina, de Castro Medeiros, Daniel   +4 more
core   +1 more source

Exploratory Cortex Metabolic Profiling Revealed the Sedative Effect of Amber in Pentylenetetrazole-Induced Epilepsy-Like Mice

, 2019
Epilepsy is a common clinical syndrome characterized by sudden and recurrent attacks and temporary central nervous system dysfunction caused by excessive discharge of neurons in the brain.
Yue Zhu, Dawei Qian, Jianming Guo, Sheng Guo, Jinao Duan, Zhenhua Zhu, Erxin Shang, Ming Zhao, Chenkai Chen, Hui Yan, Zhishu Tang   +10 more
core   +1 more source