Results 61 to 70 of about 6,209 (222)

Peripheral Infection after Traumatic Brain Injury Augments Excitability in the Perilesional Cortex and Dentate Gyrus

Biomedicines, 2021
Peripheral infections occur in up to 28% of patients with traumatic brain injury (TBI), which is a major etiology for structural epilepsies. We hypothesized that infection occurring after TBI acts as a “second hit” and facilitates post-traumatic ...
Ying Wang, Pedro Andrade, Asla Pitkänen
doaj   +1 more source

The ionic mechanism of the pentylenetetrazol convulsions. [PDF]

Acta biologica Hungarica, 1987
The ionic dependence and the nature of conductance was examined at slowly inactivating inward current in metacerebral giant cells of Helix pomatia, induced by 50 mM pentylenetetrazol. Ramp and square wave depolarizations in voltage clamp mode revealed, that withdrawal of sodium ions prevented this current to flow.
Papp András, Fehér Ottó, Erdelyi L.
openaire   +1 more source

Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation [PDF]

, 2023
Zebrafish (Danio rerio) assays provide a versatile pharmacological platform to test compounds on a wide range of behaviors in a whole organism. A major challenge lies in the lack of knowledge about the bioavailability and pharmacodynamic effects of ...
Simon Ming-Yuen Lee, Skalicka-Woźniak, Krystyna, Veronika Morozova, Daniele Pellegata, Budzyńska, Barbara, Gertsch, Jürg, Ewelina Kozioł, Jürg Gertsch, Pellegata, Daniele, Krystyna Skalicka-Woźniak, Adrianna Skiba, Lee, Simon Ming-Yuen, Barbara Budzyńska, Skiba, Adrianna, Kozioł, Ewelina, Morozova, Veronika   +15 more
core   +1 more source

Pioglitazone Ameliorates Hippocampal Neurodegeneration, Disturbances in Glucose Metabolism and AKT/mTOR Signaling Pathways in Pentyelenetetrazole-Kindled Mice

Pharmaceuticals, 2022
Disturbance of glucose metabolism, nerve growth factor (NGF) and m-TOR signaling have been associated with the pathophysiology of epilepsy. Pioglitazone (PGZ) is an anti-diabetic drug that shows a protective effect in neurodegenerative diseases including
Nada El-Megiri, Yasser M. Mostafa, Amal Ahmed, Eman T. Mehanna, Mona F. El-Azab, Fatma Alshehri, Hadil Alahdal, Norhan M. El-Sayed   +7 more
doaj   +1 more source

Pentylenetetrazole Kindling Affects Sleep in Rats [PDF]

Epilepsia, 2006
Summary:  Purpose: The aim of the study was to define sleep disturbances in pentylenetetrazole (PTZ)‐kindled rats and to explore the effects of the nootropic drug piracetam (Pir; 100 mg/kg) and the noncompetitive N‐methyl‐d‐aspartate (NMDA)‐antagonist MK‐801 (0.3 mg/kg), which normalized learning performance in PTZ‐kindled rats, on altered sleep ...
Markus, Schilling, Wolfram, Wetzel, Gisela, Grecksch, Axel, Becker   +3 more
openaire   +2 more sources

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, Volume 6, Issue 5, May 2026.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source

Ethosuximide affects both pentylenetetrazole- and kainate-induced clonic seizures but differentiates between tonic–clonic seizures

, 1989
Young (25-day-old) and adult (90-day-old) rats pretreated with ethosuximide (62.5 or 125 mg/kg i.p.) were injected with either s.c. pentylenetetrazole (100 mg/kg) or i.p. kainate (10 or 14 mg/kg). The incidences and latencies of minor (clonic) and major
Pavel Mareš, Jana Velíšková, Helena Mirvaldová, Libor Velíšek, Ivana Kulhánková, Lenka Roztočilová   +5 more
core   +1 more source

Pentylenetetrazole-Induced Kindling Mouse Model [PDF]

Journal of Visualized Experiments, 2018
Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of PTZ into an animal induces an acute, severe seizure at a high dose, whereas sequential injections of a subconvulsive dose have been used for the development of chemical kindling, an epilepsy model.
Tadayuki, Shimada, Kanato, Yamagata
openaire   +2 more sources

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Pentylenetetrazole inhibits glutamate dehydrogenase and aspartate aminotransferase, and stimulates GABA aminotransferase in homogenates from rat cerebral cortex

, 1988
The mechanism by which pentylenetetrazole provokes convulsions in animals has been investigated by measuring its influence in vitro on the activities of several enzymes of glutamate metabolism in rat brain homogenates. Pentylenetetrazole does not affect
Silvia Bartolucci, Lucille Lacoste, Jacques Lapointe   +2 more
core   +1 more source