Results 61 to 70 of about 7,019 (224)

Magnesium and Zinc Oxide Nanoparticles from Datura alba Improve Cognitive Impairment and Blood Brain Barrier Leakage

Molecules, 2022
Epilepsy is a neurological disorder involving persistent spontaneous seizures and uncontrolled neuronal excitability that leads to cognitive impairments and blood–brain barrier (BBB) disruption.
Habib Ullah, Ikram Ullah, Gauhar Rehman, Muhammad Hamayun, Sajid Ali, Abdur Rahman, In-Jung Lee   +6 more
doaj   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, Volume 183, Issue 23, Page 6767-6786, December 2026.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Pentylenetetrazole inhibits glutamate dehydrogenase and aspartate aminotransferase, and stimulates GABA aminotransferase in homogenates from rat cerebral cortex

, 1988
The mechanism by which pentylenetetrazole provokes convulsions in animals has been investigated by measuring its influence in vitro on the activities of several enzymes of glutamate metabolism in rat brain homogenates. Pentylenetetrazole does not affect
Silvia Bartolucci, Lucille Lacoste, Jacques Lapointe   +2 more
core   +1 more source

Pentylenetetrazole-Induced Kindling Mouse Model [PDF]

Journal of Visualized Experiments, 2018
Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of PTZ into an animal induces an acute, severe seizure at a high dose, whereas sequential injections of a subconvulsive dose have been used for the development of chemical kindling, an epilepsy model.
Tadayuki, Shimada, Kanato, Yamagata
openaire   +2 more sources

4‐Thiazolidinone/2,4‐Thiazolidinedione–Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Sulfonamide–thiazolidinone hybrids integrate complementary pharmacophores to generate multifunctional scaffolds with broad pharmacological potential. Their structural versatility supports antimicrobial, antifungal, antioxidant, anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, and enzyme‐inhibitory activities.
Subham Kumar Vishwakarma, Andressa Francielli Bonjorno, Sukhwant Singh, Christian S. Carnero Canales, Jean Leandro dos Santos, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan   +6 more
wiley   +1 more source

Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy

Advanced Science, Volume 13, Issue 57, 14 October 2026.
A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan, Yuling Xu, Ting Yu, Yang Li, Xin Jiang, Haoyu Jin, Haitao Li, Youyu Zhang, Peng Yin, Jong Seung Kim   +9 more
wiley   +1 more source

Long-term l-NAME treatment potentiates the blood–brain barrier disruption during pentylenetetrazole-induced seizures in rats

, 2006
We investigated whether the severity of blood-brain barrier disruption caused by pentylenetetrazole-induced seizures is modified by long-term nitric oxide synthase inhibition in rats.
Rivaze Kalayci, Mutlu Kucuk, Kaya, Mehmet, Nadir Arican, Arican, Nadir, Bulent Ahishali, Ahishali, Bülent, Elmas, Imdat, Mehmet Kaya, Imdat Elmas, kalaycı, RİVAZE, Kucuk, Mutlu, KALAYCI, RİVAZE   +12 more
core   +1 more source

The Combined Effect of Aerobic Exercise and α-Pinene on Pentylenetetrazole-Induced Seizure in Male Rats

Caspian Journal of Neurological Sciences, 2022
Background: Seizure is due to the abnormal electric activity of neurons in the brain. Because of the side effects of synthetic drugs, plant medicines can be used instead to control seizures.
Sadegh Lotfinesab, Abdolhassan Doulah, Maryam Rafieirad   +2 more
doaj  

Anticonvulsant effects of Lippia citriodora (Verbenaceae) leaves ethanolic extract in mice: Role of gabaergic system

International Journal of Preventive Medicine, 2016
Background: Lippia citriodora Kunth is one of the Iranian traditional medicines for the treatment of convulsive disorders. The goal of this study is to investigate the anticonvulsant activity of the plant′s leave ethanolic extract against electro- and ...
Amir Rashidian, Forogh Farhang, Habib Vahedi, Ahmad Reza Dehpour, Shahram Ejtemai Mehr, Saeed Mehrzadi, Seyed Mahdi Rezayat   +6 more
doaj   +1 more source

Psilocybin, From Ancestral Use to Therapeutic Potential: A Multidimensional Review of Its Pharmacological Basis and Current Perspectives

Human Psychopharmacology: Clinical and Experimental, Volume 41, Issue 5, September 2026.
ABSTRACT Objective This review critically examines psilocybin, with particular emphasis on its pharmacokinetics and pharmacodynamics, including its serotonergic, neuroplastic, and anti‐inflammatory mechanisms. It integrates historical context, preclinical and clinical evidence, and evaluates emerging therapeutic potential, safety, microdosing practices,
José Norberto Vásquez‐Bonilla
wiley   +1 more source