Results 61 to 70 of about 9,677 (229)
Anticonvulsant effect of minocycline on pentylenetetrazole-induced seizure in mice: involvement of nitric oxide and N-methyl-D-aspartate receptor [PDF]
, 2017 Anticonvulsant effects of minocycline have been explored recently. This study was designed to examine the anticonvulsant effect of acute administration of minocycline on pentylenetetrazole-induced seizures in mouse considering the possible role of the ...
Amini-Khoei, Hossein +9 more
core
Pentylenetetrazole-Induced Kindling Mouse Model [PDF]
Journal of Visualized Experiments, 2018 Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of PTZ into an animal induces an acute, severe seizure at a high dose, whereas sequential injections of a subconvulsive dose have been used for the development of chemical kindling, an epilepsy model.
Tadayuki, Shimada, Kanato, Yamagata
openaire +2 more sources
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.The mTOR/GLT‐1 pathway abnormality induces α‐synucleinopathy, contributing to seizures in FCD lesions, which were rescued by treatment with the mTOR inhibitor Rapa or the GLT‐1 enhancer Cef. Intracerebroventricular α‐syn administration attenuated PTZ‐induced seizures in FCD models.
Li Zhang +6 more
wiley +1 more source
Sedacijski i antikonvulzijski učinci vodenog iscrpka kore stabljike sikomore Ficus sycomorus L. (Moraceae) u štakora. [PDF]
, 2003 The aqueous extract of the stembark of Ficus sycomorus was prepared and used as 0.2 mg/ ml. Seventy white albino rats of both sexes weighing between 101 g and 120 g were used for this study.
Gregory Anene Chibuzo +2 more
core +1 more source
Epilepsy: Molecular Pathogenesis and Emerging Therapies
MedComm, Volume 7, Issue 4, April 2026.Progress has been made in the molecular pathogenesis of epilepsy, revealing multiple therapeutic targets. Recent advances in pharmacology, materials science, and surgical technique, coupled with progress in targeted therapy and disruptive epilepsy network technology, have led to the emergence of innovative strategies for epilepsy treatment.
Wanbin Huang +5 more
wiley +1 more source
Caspian Journal of Neurological Sciences, 2022 Background: Seizure is due to the abnormal electric activity of neurons in the brain. Because of the side effects of synthetic drugs, plant medicines can be used instead to control seizures.
Sadegh Lotfinesab +2 more
doaj
International Journal of Preventive Medicine, 2016 Background: Lippia citriodora Kunth is one of the Iranian traditional medicines for the treatment of convulsive disorders. The goal of this study is to investigate the anticonvulsant activity of the plant′s leave ethanolic extract against electro- and ...
Amir Rashidian +6 more
doaj +1 more source
Investigation of the Effect of Anakinra on Pentylenetetrazole-Induced Epileptic Seizures in Mice
Ahi Evran Medical Journal, 2021 Purpose: Disruption of the balance between gamma aminobutyric acid (GABA) and glutamate in the brain is one of the important factors contributing to seizure formation and epileptogenesis.
Ahmet Kemal FİLİZ +1 more
doaj +1 more source
Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease
Epilepsia, Volume 67, Issue 3, Page 1449-1468, March 2026.Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa +17 more
wiley +1 more source
Clock gene dysregulation in epilepsy: A systematic review
Epilepsia Open, Volume 11, Issue 1, Page 53-77, February 2026.Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos +3 more
wiley +1 more source