Results 61 to 70 of about 4,421 (183)

Impact of Gastrodia elata on Neuroinflammation and Epilepsy in a Rat Model

Medical Journal of Babylon
Background: Gastrodia elata (GE) is a traditional Chinese herb, a type of Orchidaceae, which has antiepileptic and anti-inflammatory effects. Objectives: To investigate the impact of GE on behavioral changes and inflammation after induction of seizures ...
Noor-Alhuda Mohammed Alebadi, Reyadh H. Al-Mosawi, Mufeed Jalil Ewadh   +2 more
doaj   +1 more source

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source

Effect of acute L-carnitine administration alone or combination with sodium valproate on pentylenetetrazole- induced seizures in mice

Fiyz̤, 2021
Background: L-carnitine, as an endogenous compound, has paradoxical effects on seizures. This study aimed to evaluate the effect of acute administration of L-carnitine alone or combination with sodium valproate on pentylenetetrazole (PTZ) induced ...
Morteza Vaghefi-Esfidani, Azhdar Heydari
doaj  

Anticonvulsant Effect of Alcea aucheri on Pentylenetetrazole and Maximal Electroshock Seizures in Mice

Basic and Clinical Neuroscience, 2020
Introduction: This study was designed to investigate the possible anticonvulsant effect of acute administration of an aqueous extract of flowers of Alcea aucheri (EFA) in two in vivo seizure models. Methods: Seizures were induced in male adult Swiss mice
Tajmah Mombeini, Babak Asadpour Behzadi, Ramtin Ejtemaei, Freidoun Tahmasbi, Mohammad Kamalinejad, Ahmad Reza Dehpour   +5 more
doaj  

Assessment of Anticonvulsant Activities of Petroleum Ether Extract of Anacyclus pyrethrum Roots on Experimental Rats

Pharmaceutical and Biomedical Research, 2020
Background: Epilepsy is one of the most common neurological conditions and a significant cause of morbidity and mortality. Objectives: The present study aimed to evaluate the anticonvulsant activity of the petroleum ether extract of the root of ...
Bashir A. Yousef, Zeinab Awad, Somaya Adam, Setalbanat Abdelgadir, Ansam Mergani   +4 more
doaj  

Comparison of the Effect of Verapamil, Nifedipine and Diltiazem on Pentylenetetrazole-Induced Clonic Seizure Threshold in Mice

پزشکی بالینی ابن سینا, 2007
Background & Objective: Verapamil, nifedipine and diltiazem are calcium channel blockers widely used as a variety of cardiovascular ailment in humans. A number of studies have shown that calcium channel blockers have anticonvulsant effect in a range of ...

doaj  

ffects of morphine_ dependence on the induction and modulation of epileptic seizures in rats [PDF]

Journal of Kerman University of Medical Sciences, 1997
Kindling is a very suitable animal model for studying basis mechanisms of epilepsy. In this model , repeated exposure to weak electrical or chemical increases neuronal excitability and there fore decreases the threshold for induction of epileptic ...
N Atapour, M Niyazi
doaj  

Synthesis of 5-Alkoxythieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine Derivatives and Evaluation of Their Anticonvulsant Activities

Molecules, 2015
This work concerns the design and synthesis of novel, substituted 5-alkoxythieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 5a–p prepared from 3-amino-2-thiophenecarboxylic acid methyl ester.
Shi-Ben Wang, Guang-Chun Piao, Hong-Jian Zhang, Zhe-Shan Quan   +3 more
doaj   +1 more source

Improving Kv7 targeting anticonvulsants ‐ will repurposing save the day?

British Journal of Pharmacology, Volume 183, Issue 3, Page 435-437, February 2026.
Nikita Gamper
wiley   +1 more source

Effects of Pentachlorophenol, Pentylenetetrazol and Carnitine on Mitochondria

Journal of UOEH, 1998
Pentachlorophenol (PCP) increased oxygen consumption and lowered the respiratory control ratio (RCR) in mitochondria from rat liver. These effects of PCP were lessened by 1 mM L-carnitine but not by D-carnitine. In contrast, up to 150 mM of pentylenetetrazol (PTZ) added at state 4 of respiration did not accelerate oxygen consumption.
Z, Yu, Y, Iryo, M, Matsuoka, H, Igisu
openaire   +3 more sources