Results 1 to 10 of about 70,161 (298)

Synthesis methods of 1,2,3-/1,2,4-triazoles: A review

Frontiers in Chemistry, 2022
Triazole, comprising three nitrogen atoms and two carbon atoms, is divided into two isomers 1,2,3-triazole and 1,2,4-triazole. Compounds containing a triazole are one of the significant heterocycles that exhibit broad biological activities, such as ...
Jinlian Dai, Sen Tian, Xueqing Yang, Zongliang Liu   +3 more
doaj   +1 more source

Fluorescent Analogues of FRH Peptide: Cu(II) Binding and Interactions with ds-DNA/RNA

Chemosensors, 2022
Four novel peptidoids, derived from the Phe-Arg-His (FRH) peptide motif, were prepared by replacing the histidine heterocycle with triazole and consequent triazole-fluorophore (coumarin) extension and also replacing arginine with less voluminous lysine ...
Marta Košćak, Ivona Krošl, Biserka Žinić, Ivo Piantanida   +3 more
doaj   +1 more source

Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles

Tetrahedron Chem, 2022
The synthesis and characterisation of axially chiral atropisomeric 1,5-disubstituted 1,2,3-triazoles is reported. Molecules designed to display restricted rotation about 1,2,3-triazole N-1-aryl or 1,2,3-triazole C-5-aryl bonds were investigated by ...
Fernanda Meloni, William D.G. Brittain, Louise Male, Cécile S. Le Duff, Benjamin R. Buckley, Andrew G. Leach, John S. Fossey   +6 more
doaj   +1 more source

Genome-Wide Association Analysis for Triazole Resistance in Aspergillus fumigatus

Pathogens, 2021
Aspergillus fumigatus is a ubiquitous fungus and the main agent of aspergillosis, a common fungal infection in the immunocompromised population. Triazoles such as itraconazole and voriconazole are the common first-line drugs for treating aspergillosis ...
Yuying Fan, Yue Wang, Gregory A. Korfanty, Meagan Archer, Jianping Xu   +4 more
doaj   +1 more source

Triazole-Resistance in Environmental Aspergillus fumigatus in Latin American and African Countries

Journal of Fungi, 2021
Triazole-resistance has been reported increasingly in Aspergillus fumigatus. An international expert team proposed to avoid triazole monotherapy for the initial treatment of invasive aspergillosis in regions with >10% environmental-resistance, but this ...
Agustin Resendiz-Sharpe, Klaas Dewaele, Rita Merckx, Beatriz Bustamante, Maria Celeste Vega-Gomez, Miriam Rolon, Jan Jacobs, Paul E. Verweij, Johan Maertens, Katrien Lagrou   +9 more
doaj   +1 more source

Triazole analogues as potential pharmacological agents: a brief review

Future Journal of Pharmaceutical Sciences, 2021
Background A large number of studies have recently reported that, because of their significant biological and pharmacological properties, heterocyclic compounds and their derivatives have attracted a strong interest in medicinal chemistry.
Sachin Kumar, Sukhbir Lal Khokra, Akash Yadav   +2 more
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The anti-HIV, anti-tumor activity of allyl derivatives of 1,2,4-triazole-5-thione, 1,3,4-thiadiazol-2-ylamine and derivatives of bicyclic systems: 1,2,4-triazole[3,4-b]1,3-thiazine, 1,2,4-triazole[3,2-b]1,3-thiazine, thiazolo[2,3-c][1,2,4]triazole

Current Issues in Pharmacy and Medical Sciences, 2012
The isomerization of 5H-3,7-diphenyl 6,7-dihydro-1,2,4-triazole[3,4-b] 1,3-thiazine (1) in a sealed tube, in the presence of aqueous Hbr, was carried out, and 7H-2,5-diphenyl-5,6-dihydro 1,2,4-triazole[3,2-b]1,3-thiazine (2) was obtained.
Leokadia Strzemecka
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Acute toxicity of 5-(2-, 3-, 4-methoxyphenyl, (3,4,5-trimethoxyphenyl)-)-1,2,4-triazole-3-thiones and its thioderivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
Aim. We have continued the study of 1,2,4-triazole derivatives, which contain 2-, 3- , 4-methoxyphenyl or 3,4,5- methoxyphenyl substituents in 5th position of the triazole nucleus.
Yu. G. Samelyuk , A. G. Kaplaushenko
doaj   +1 more source

Synthesis and Characterization of the Triazole Derived from Thiosemicarbazide, 4-Amino-5-Phenyl-4H-1,2,4- Triazole-3-Thiol and Their Copper(II) and Nickel(II) Complexes [PDF]

Engineering and Technology Journal, 2013
Triazole N-(3-mercapto-5-phenyl-4H-1,2,4-triazol-4-yl)hydrazinecarbothioamide prepared in good yield via the condensation of 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol and thiosemicarbazide.
Hamdan Abood Aday
doaj   +1 more source

Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r'-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
The aim of study was to investigate diuretic activity of 1,2,4-triazole derivatives which contain С5 atom 5-bromfuran-2-yl substituent in the 1,2,4-triazole nucleus, and to establish interrelation between chemical structure and diuretic action of 1,2,4 ...
Ye. S. Pruglo, A. S. Gotsulya, O. I. Panasenko, Ye. G. Knysh   +3 more
doaj   +1 more source